Proceedings from the Albert Charitable Trust Inaugural Workshop on ‘Understanding the Acute Effects of Exercise on the Brain’

Barnes, Jill N.; Burns, Jeffrey M.; Bamman, Marcas M.; Billinger, Sandra A.; Bodine, Sue C.; Booth, Frank W.; Brassard, Patrice; Clemons, Tameka; Fadel, Paul J.; Geiger, Paige C.; Gujral, Swathi; Haus, Jacob M.; Kanoski, Scott E.; Miller, Benjamin F.; Morris, Jill K.; O’Connell, Kristin M.S.; Poole, David C.; Sandoval, Darleen A.; Smith, J. Carson; Swerdlow, Russell H.; Whitehead, Shawn N.; Vidoni, Eric D.; Praag, Henriette van

doi:10.3233/bpl-220146

Cited by 2 publications

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“…Deficits therein are associated with reduced hippocampal volume and degradation of synaptic connectivity between (peri)entorhinal cortex and the hippocampus (Yassa et al, 2010(Yassa et al, , 2011Burke et al, 2011). Increasing evidence indicates that physical activity can delay or prevent such structural and functional reductions in older adults (Erickson et al, 2011;Voss et al, 2013Voss et al, , 2019Duzel et al, 2016;Gaitán et al, 2021;Barnes et al, 2022). The underlying mechanisms are considered to involve central and systemic changes that result in increased levels of hippocampal neurotrophins, neurotransmitters, vascularization, and attenuated inflammation (Huuha et al, 2022;Gao et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired

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et al. 2023

eNeuro

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Exercise may prevent or delay aging-related memory loss and neurodegeneration. In rodents, running increases the number of adult-born neurons in the dentate gyrus (DG) of the hippocampus, in association with improved synaptic plasticity and memory function. However, it is unclear if adult-born neurons remain fully integrated into the hippocampal network during aging and whether long-term running affects their connectivity. To address this issue we labeled proliferating DG neural progenitor cells with retrovirus expressing the avian TVA receptor in 2-month-old sedentary and running male C57Bl/6 mice. More than six months later, we injected EnvA-pseudotyped rabies virus into the DG as a monosynaptic retrograde tracer, to selectively infect TVA expressing ‘old’ new neurons. We identified and quantified the direct afferent inputs to the adult-born neurons within the hippocampus and (sub)cortical areas. Here we show that long-term running substantially modifies the network of the neurons generated in young adult mice upon middle-age. Exercise increases input from hippocampal interneurons onto ‘old’ adult-born neurons, which may play a role in reducing aging-related hippocampal hyperexcitability. In addition, running prevents the loss of adult-born neuron innervation from perirhinal cortex, and increases input from subiculum and entorhinal cortex, brain areas that are essential for contextual and spatial memory. Thus, long-term running maintains the wiring of ‘old’ new neurons, born during early adulthood, within a network that is important for memory function during aging.Significance statementExercise benefits brain function, however, the underlying mechanisms remain unclear. We show that long-term running increases hippocampal neurogenesis, and modifies the network of new neurons that were born in young adult mice, in a manner that optimally supports memory function at middle age.

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