Proceedings: Discussion

Herr, William McD.

doi:10.1093/ajae/61.1.167

Cited by 1 publication

(2 citation statements)

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“…This implies that a transition from Cluster I to Cluster III is linked to an increased expressional diversity. We suggest that this diversity may contribute to the recognized unpredictability of the clinical behavior of TaG3/T1 tumors (Herr, 2000). To identify genes of importance for the development and heterogeneity of UCCs we performed non-hierarchical clustering of genes to identify groups of coexpressed genes varying across the tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from displaying a high risk of recurrent disease, most superficial tumors are of low grade (G1 or G2), rarely progress, and are associated with a highly favorable prognosis (Prout et al, 1992;Haukaas et al, 1999). In contrast, high-grade Ta tumors (TaG3), and T1 tumors, represent a significant risk of future tumor progression and death from the disease (Herr, 2000). Even though factors such as tumor stage, grade, size, multifocality, recurrence rate and presence of concomitant carcinoma in situ (Tis) contribute with prognostic information, the course of the individual disease is hard to predict.…”

Section: Introductionmentioning

confidence: 99%

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Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q

et al. 2006

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We used gene expression profiling, mutation analyses of FGFR3 and TP53, and LOH analyses of chromosome 9 and the TP53 region on chromosome arm 17p, to molecularly characterize 75 Ta and T1 bladder carcinomas. We identified four major cellular processes related to cell cycle, protein synthesis, immune response, and extra cellular components that contribute to the expressional heterogeneity of early-stage urothelial cell carcinoma (UCC). Activating FGFR3 mutations were found at the highest frequency in G1 tumors (80%), and showed a strong correlation with FGFR3 expression. In contrast, G3 tumors displayed mutations in less than 10% of the cases and a low level of FGFR3 expression. Even though LOH on chromosome 9 was not associated with any specific expression pattern, our data indicate that loss of chromosome 9 is associated with tumor development rather than initiation. The combined analyses suggest the existence of two types of UCC tumors, one which is characterized by FGFR3 mutation or expression, high expression of protein synthesis genes, and low expression of cell cycle genes. Furthermore, the presented data underscore FGFR3 receptor involvement in urothelial cell transformation as the presence of FGFR3 mutations has a major impact on the global gene expression profile of bladder carcinomas.

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Section: Discussionmentioning

confidence: 99%