“…In clinical research, participants frequently have significant difficulties in understanding some research methodologies like randomised control trials (Cox, 2000;Daugherty et al, 1995;Joffe et al, 2001), although the extent of this misunderstanding might be unclear . Participants generally seem to operate under the mistaken assumption (referred to as 'therapeutic misconception' in the literature) that participation in such trials will guarantee receipt of an effective therapeutic intervention (appelbaum, 2002;appelbaum et al, 2004;Bamberg and Budwig, 1992;Fisher, J.a., 2006;Jansen, 2006;Kimmelman, 2007;King et al, 2005;Miller and Brody, 2003;Miller and Joffe, 2006;Stead et al, 2005). One of the concerns in the literature has been what investigators contribute to this misunderstanding and whether there are effective means to avoid or correct the therapeutic misconception (hochhauser, 2002;Jansen, 2006;Joffe et al, 2001;King, 2000).…”