Procalcitonin Under the Course of Budesonide Inhalation Therapy in Recurrent Airway Obstruction

Barton, Ann Kristin; Pelli, Anna; Rieger, Martin; Gehlen, Heidrun

doi:10.1016/j.jevs.2016.06.072

Cited by 3 publications

(11 citation statements)

References 40 publications

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“…34 Inhalation of budesonide (1500 g q12h, 10 days) decreased airway neutrophilia in horses with SEA, but the treatment was accompanied by a low-dust environment and there was no control group. 62 The nebulization of dexamethasone (15 mg q24h, 13 days) does not modify BALF cytology in mild asthma. 74 Combined, these results suggest that the environment, rather than GC, is mainly responsible for the improvement of airway neutrophilic inflammation in many studies.…”

Section: Effects Of Gc On Balf Cell Populationsmentioning

confidence: 97%

“…17 Nebulized budesonide (1500 μg q12h, 10 days) improves the respiratory clinical score during exacerbation of SEA, but not during remission. 62 The interpretation of these latter results needs caution as a low-dust environment was also implemented and the study lacked a control group. 62 The nebulization of the injectable form of dexamethasone (5 mg q24h, 7 days) does not improve lung function in SEA, whereas it significantly suppresses the endogenous cortisol production.…”

Section: Inhaled Administration Of Gcmentioning

confidence: 99%

“…62 The interpretation of these latter results needs caution as a low-dust environment was also implemented and the study lacked a control group. 62 The nebulization of the injectable form of dexamethasone (5 mg q24h, 7 days) does not improve lung function in SEA, whereas it significantly suppresses the endogenous cortisol production. 25 These results contrast from findings in healthy horses, where nebulized dexamethasone at the same dose does not suppress the hypothalamic-pituitary-adrenal (HPA) axis and has a low systemic bioavailability.…”

Section: Inhaled Administration Of Gcmentioning

confidence: 99%

Section: Effects Of Gc On the Lung Functionmentioning

confidence: 99%

“… 62 The interpretation of these latter results needs caution as a low‐dust environment was also implemented and the study lacked a control group. 62 …”

Section: Effects Of Gc On the Lung Functionmentioning

confidence: 99%

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Glucocorticoid treatment in horses with asthma: A narrative review

Mainguy-Seers

Lavoie

2021

Veterinary Internal Medicne

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Despite substantial research efforts to improve the treatment and outcome of horses with asthma, glucocorticoids (GC) remain the cornerstone of drug treatment of this prevalent disease. The high efficacy of GC to relieve airway obstruction explains their extensive use despite potential deleterious effects. However, much is yet to be uncovered concerning GC use in horses with asthma, including the comparative efficacy of the different drugs, the determination of minimal effective doses and the mechanisms underlying their variable modulation of airway inflammation. The objectives of this structured review were to report and compare the plethora of effects of the various GC used in asthmatic horses with a focus on impact on lung function, airway inflammation, and bronchial remodeling. Adverse effects are also briefly described, with an emphasis on those that have been specifically reported in horses with asthma. Ultimately, we aimed to highlight gaps in the literature and to identify future research areas.

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Section: Effects Of Gc On Balf Cell Populationsmentioning

confidence: 97%

Section: Inhaled Administration Of Gcmentioning

confidence: 99%

Section: Inhaled Administration Of Gcmentioning

confidence: 99%

Section: Effects Of Gc On the Lung Functionmentioning

confidence: 99%

“… 62 The interpretation of these latter results needs caution as a low‐dust environment was also implemented and the study lacked a control group. 62 …”

Section: Effects Of Gc On the Lung Functionmentioning

confidence: 99%

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Glucocorticoid treatment in horses with asthma: A narrative review

Mainguy-Seers

Lavoie

2021

Veterinary Internal Medicne

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Some Genetic and Environmental Effects on Equine Asthma in Polish Konik Horses

Borowska

Wolska

Niedźwiedź

et al. 2021

Animals

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Current knowledge of the genetic and environmental backgrounds of equine asthma seems to be insufficient, especially for primitive horse breeds. The main objectives of this study were to estimate the effects of sex, birth period, stud, parentage line and inbreeding on asthma morbidity in Polish Konik horses. Records of 274 horses (housed in two studs) were analysed. These animals were allocated to maternal and paternal lines. Individual inbreeding coefficients were extracted from the additive relationship matrix. Horses underwent diagnosis based on observation of the basic symptoms (high frequency of coughing and excessive nasal discharge). Subsequently, some horses (28 individuals) were clinically examined to confirm the earlier observations. Generally, no significant effects of parentage line on heaves morbidity were identified by the use of logistic regression, although the Pearson’s chi-squared test had shown that individuals of some maternal and paternal lines had a predisposition to severe equine asthma. It was concluded that the individual inbreeding level is not associated with the incidence of EA, but a significant effect of the maternal inbreeding coefficient may be observed. It was also found that there is some variability in the incidence of this disease between studs.

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Can Procalcitonin Be Dosed in Bovine Milk Using a Commercial ELISA Kit?

Meucci

Orsetti

Sgorbini

et al. 2022

Animals

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The aim was to evaluate the use of a bovine procalcitonin (PCT) ELISA kit (Cusabio, China) for assessing PCT in bovine milk samples. Validation was performed by using 10 plasma and corresponding milk samples from mastitic cows. The limit of detection (LOD) was calculated. The coefficient of variation (CV%) of the readings of five plasma samples measured five times in the same plate (intra-assay) and the CV% of the same five samples read five times in three separate plates was evaluated. Parallelism was determined by serial twofold dilutions of five plasma and corresponding milk samples. Milk samples were analyzed with and without centrifugation. Regarding plasma PCT, the method presented an inter- and intra-CV < 23.7% and parallelism had very good recovery values. The ELISA kit studied can measure bovine plasma PCT concentrations. The kit antibodies fail in binding PCT in milk samples because all centrifuged milk samples showed a lower LOD than blank samples. Only three uncentrifuged milk samples showed measurable PCT concentrations. Due to these results, the commercial ELISA kit investigated could not be employed for the detection of PCT in milk samples.

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Procalcitonin Under the Course of Budesonide Inhalation Therapy in Recurrent Airway Obstruction

Cited by 3 publications

References 40 publications

Glucocorticoid treatment in horses with asthma: A narrative review

Glucocorticoid treatment in horses with asthma: A narrative review

Some Genetic and Environmental Effects on Equine Asthma in Polish Konik Horses

Can Procalcitonin Be Dosed in Bovine Milk Using a Commercial ELISA Kit?

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