Procalcitonin to Reduce the Number of Unnecessary Cystographies in Children with a Urinary Tract Infection: A European Validation Study

Leroy, Sandrine; Romanello, Carla; Galetto-Lacour, Annick; Smolkin, Vladislav; Korczowski, Bartosz; Corrêa-Oliveira, Rodrigo; Tuerlinckx, David; Gajdos, Vincent; Moulin, F.; Contardo, Marzia; Gervaix, Alain; Halevy, Raphaël; Duhl, Barbara; Prat, Cristina; Borght, Thierry Vander; Foix‐L’Hélias, L.; Dubos, François; Gendrel, D.; Breart, Gérard; Chalumeau, Martin

doi:10.1016/j.jpeds.2006.08.066

Cited by 58 publications

(30 citation statements)

References 38 publications

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“…The association of PCT values with VUR in children with febrile UTI remains controversial [25][26][27][28] The current study shows a signifi cant difference in PCT values between children with and without VUR, in accordance to the previously published data [25][26][27][28][31][32][33][34] . An earlier multicenter study of 398 patients in 8 centers in 7 European countries, in which DMSA was not performed in all patients [26] and strongly showed that PCT is a predictor of VUR independently of its relationship with early parenchymal involvement regardless of the urine-collection technique used for the diagnosis of UTI.…”

Section: Discussionsupporting

confidence: 91%

“…Two more studies by Leroy et al [26,28], have also confi rmed the relationship between PCT and VUR. A PCT level of > 0.5 ng/mL gave a sensitivity of 83% and a specifi city of 43% for high-grade VUR, regardless of the presence of early renal parenchymal involvement in children with a fi rst UTI [28].…”

Section: Discussionmentioning

confidence: 87%

“…A PCT level of > 0.5 ng/mL gave a sensitivity of 83% and a specifi city of 43% for high-grade VUR, regardless of the presence of early renal parenchymal involvement in children with a fi rst UTI [28]. The sensitivity of PCT (> 0.5 ng/mL) as a predictor of VUR was 75% for all grades of VUR, and the specifi city was 43% [26].…”

Section: Discussionmentioning

confidence: 97%

“…An earlier multicenter study of 398 patients in 8 centers in 7 European countries, in which DMSA was not performed in all patients [26] and strongly showed that PCT is a predictor of VUR independently of its relationship with early parenchymal involvement regardless of the urine-collection technique used for the diagnosis of UTI.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27][28].However, this assumption still needs more confi rmatory studies. The aim of this prospective cohort study was to determine whether we can use serum procalcitonin concentration as a marker of VUR presence or VUR degree in hospitalized children with fi rst febrile UTI.…”

Section: Amongst Bacterial Infections Urinary Tract Infection (Uti)mentioning

confidence: 99%

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Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection

Shalaby¹,

Elsayed²

2017

Arch Clin Nephrol

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Background: Procalcitonin (PCT) has been proposed as a novel biomarker for prediction of Vesicoureteral Refl ux (VUR). Since VUR is the most important risk factor for occurrence of pyelonephritis and renal tissue infl ammation, serum PCT level may have a relationship with VUR. However, literature about the relationship between procalcitonin level and VUR is scanty. Aim:We evaluated the predictive value of serum PCT level in the diagnosis of VUR in children admitted with their fi rst febrile UTI. Methods:We investigated 140 children with the fi rst febrile UTI (2m-10 yrs.). Serum PCT was measured before initiation of antibiotics. Standard voiding cystourethrography (VCUG) was performed in all children as the gold standard for detection of VUR. Sensitivity and specifi city of a high PCT level was evaluated using the receiver operating characteristic curve.Results: Seventy three patients(52%) had no VUR, while 67patients (48%) had VUR at least in one kidney, including grade 1 to 2 in 20 patients (14.3%) and , grade 3-5 in 47 (34.7%). PCT level ranged from 0.45 ng/ml to 12.7 ng/ml and, was signifi cantly higher with increasing the grading of VUR. Comparing procalcitonin levels with VCUG results, a sensitivity of 94% and a specifi city of 72% was obtained at a procalcitonin level of 0.52 ng/ml for diagnosis dilating VUR. There was a signifi cant correlation between PCT level and C-reactive protein. Conclusion:This study described that the PCT as an infl ammatory marker with proper sensitivity, specifi city, PPV and NPV seems likely benefi cial to predict dilating VUR.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Amongst Bacterial Infections Urinary Tract Infection (Uti)mentioning

confidence: 99%

See 3 more Smart Citations

Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection

Shalaby¹,

Elsayed²

2017

Arch Clin Nephrol

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Use of Procalcitonin Assays to Predict Serious Bacterial Infection in Young Febrile Infants

et al. 2016

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IMPORTANCE The procalcitonin (PCT) assay is an accurate screening test for identifying invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are insufficient. OBJECTIVE To assess the diagnostic characteristics of the PCT assay for detecting serious bacterial infection (SBI) and IBI in febrile infants aged 7 to 91 days. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study that included infants aged 7 to 91 days admitted for fever to 15 French pediatric emergency departments was conducted for a period of 30 months (

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UTI and VUR

Beetz

2018

Pediatric Urogenital Radiology

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Procalcitonin to Reduce the Number of Unnecessary Cystographies in Children with a Urinary Tract Infection: A European Validation Study

Cited by 58 publications

References 38 publications

Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection

Serum Procalcitonin Level is a Useful Predictor of Dilating Vesicoureteral Reflux in Patients with First Febrile Urinary Tract Infection

Use of Procalcitonin Assays to Predict Serious Bacterial Infection in Young Febrile Infants

UTI and VUR

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