Procalcitonin Level and Its Predictive Effect on Mortality in Crimean-Congo Hemorrhagic Fever Patients

Abstract

SUMMARY: Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal disease which is endemic to Turkey. We aimed to investigate the procalcitonin levels and their prognostic value over fatality in CCHF patients. The sera were harvested from patients who were diagnosed with CCHF within the first 2 days of the onset of their symptoms. The patients were divided into 2 groups according to their survival status: fatal or non-fatal. The biochemical and hematological parameters were studied in the Biochemistry Laboratory of Sorgun City Hospital. The sera were stored at -809 C until testing for procalcitonin, and the procalcitonin levels were assayed by ELISA at the Biochemistry Laboratory of Kirikkale University. Forty-eight patients were included in the study, with 8 and 40 patients in the fatal and non-fatal groups, respectively. While the procalcitonin level was high in all patients in the fatal group, the same was observed in 30 patients in the non-fatal group (75z). The mean value of procalcitonin was 1.12 ng/ml in the fatal group and was 0.21 ng/ml in the non-fatal group (P ＝ 0.003). According to the results of our study, the procalcitonin levels in the first 2 days of the onset of the symptoms might be helpful for predicting fatality in CCHF patients.

The association between procalcitonin, venous blood gas parameters, and clinical prognosis in patients with Crimean--Congo Hemorrhagic Fever

“…However, it has been found that increased cytokine levels also increase amount of procalcitonin synthesized by thyroid C cells in viral infections, independent of bacterial superinfections 8,19 . Procalcitonin level was reported to be higher in patients with fatal CCHF and correlated with CRP level, which is frequently used in routine practice 20 . None of the patients in our study died after clinical follow-up, and in line with previous studies, we also found that procalcitonin levels were higher in severely ill patients.…”

Kırım-Kongo Kanamalı Ateşi ile Eş Zamanlı Akut Lenfoblastik Lösemi Tanısı Alan Olgu

“…KKKA'nın; virüsün vücuda girişinden sonra vasküler endotel hasarı sonucu geliştiği düşünülmektedir 5,6 . Bunun sonucunda hastalarda lökopeni, trombositopeni, anemi ve karaciğer enzimlerinde yükselme gibi laboratuvar bulguları görülmektedir ve hastalığın prognozunda önemlidir 15,16 .…”

“…İnsanlarda ölümcül seyredebilen şiddetli bir hastalık oluşturması, aerosollerle insandan insana bulaşabilme olasılığı ve biyolojik silah olarak kullanılma riski ayrıca günümüzde virüse karşı etkinliği kanıtlanmış özgün bir tedavi ve aşı olmadığı için tüm dünyada halen önemli bir sağlık sorunudur 3,4 . Hastalığın patogenezi tam olarak bilinmemekle birlikte, vasküler endotel hasarı ön planda görülmektedir 5,6 . Hastalığın seyrinde trombositopeni, lökopeni, anemi, aktif parsiyel tromboplastin zamanı (aPTT) ve protombin zamanı (PT)'nda uzama, aspartat aminotransferaz (AST)-alanin aminotransferaz (ALT) yüksekliği, laktat dehidrogenaz (LDH) yüksekliği, kreatin kinaz yüksekliği gibi bulgular görülebilmekte ve bu bulgular diğer hastalıklarla karışabilmektedir.…”

HMGB1 Is a Potential Biomarker for Severe Viral Hemorrhagic Fevers

“…Biological markers like interleukin 6, pentraxin-3, idoleamine 2,3 dioxygenase, soluble urokinase-type plasminogen activator receptor and GATA-3 were found to correlate with severity of NE [ 10 , 11 , 12 ]. C-reactive protein (CRP) and procalcitonin (PCT) are used particularly for discrimination between bacterial and viral infections and are usually found in high levels in patients with systemic bacterial infections and were also highly elevated in HFRS and CCHF patients [ 13 , 14 , 15 , 16 ].…”