Procalcitonin in patients with acute coronary syndrome

Şentürk, Tunay; Cordan, Jale; Baran, İbrahim; Özdemir, Biilent; Güllülü, Sümeyye; Aydınlar, Ali; Göral, Güher

doi:10.2143/ac.62.2.2020233

Cited by 27 publications

(11 citation statements)

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“…hs-CRP and IL-6, as mediators and markers of atherosclerotic thrombosis, play an important role in the development of CVD [28]. The levels of hs-CRP and IL-6 in the CVD group were higher than those in the non-CVD group, consistent with the findings in previous studies [29, 30]. This suggested that the levels of hs-CRP and IL-6 were elevated, the population may be present in the pre-onset phase of CVD.…”

Section: Discussionsupporting

confidence: 90%

Nomogram Based on Cytokines for Cardiovascular Diseases in Xinjiang Kazakhs

Mao

Zhang

et al. 2019

Mediators of Inflammation

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Background. This study involved the development of a predictive 5-year morbidity nomogram for cardiovascular diseases (CVD) in Xinjiang Kazakhs based on cytokine levels. Methods. The nomogram was based on a baseline survey of the town of Nalati in the Kazakh Autonomous Prefecture of Xinjiang from 2009 to 2013. By 2016, we had monitored 1508 people for a median time of 5.17 years and identified CVD events in the study population by collecting case information from local hospitals. The study population was divided into the training (n=1005) and validation cohorts (n=503) in a 2 : 1 ratio. The area under the receiver operating characteristic curve (AUC) was used to verify the predictive accuracy of the nomogram. The result was assessed in a validation cohort. Results. At the end of the study, the incidence of CVD in Xinjiang Kazakhs was found to be 11.28%. We developed a new nomogram to predict the 5-year incidence of CVD based on age, interleukin-6 (IL-6), and adiponectin (APN) levels, diastolic blood pressure, and dyslipidemia. The AUC for the predictive accuracy of the nomogram was 0.836 (95% confidence interval: 0.802–0.869), which was higher than that for IL-6 and APN. These results were supported by validation studies. Conclusions. The nomogram model can more directly assess the risk of CVD in Kazakhs and can be used for CVD risk assessment.

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Section: Discussionsupporting

confidence: 90%

Nomogram Based on Cytokines for Cardiovascular Diseases in Xinjiang Kazakhs

Mao

Zhang

et al. 2019

Mediators of Inflammation

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“…The study by Şentürk et al identified elevated PCT and cTn levels in those with high TVCAD and that it was simultaneously correlated with mortality [7]. In our study, groups with high PCT and cTn had higher mortality, TVCAD, and complications.…”

Section: Discussionsupporting

confidence: 66%

Do MCHC, MPV, and Procalcitonin Levels Determine Prognosis in Acute Coronary Syndrome?

Karaman

Coşkun

2019

Emergency Medicine International

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Aim. Acute coronary syndrome (ACS) continues to be the main cause of mortality and morbidity globally. The aim was to assess serum procalcitonin (PCT), mean corpuscular hemoglobin concentration (MCHC) and mean platelet volume (MPV) levels in terms of complications after myocardial infarctus, triple vein coronary artery disease (TVCAD), and mortality prediction. Material and Method. This cross-sectional cohort study included 200 patients with ACS attending the emergency department of our hospital with chest pain and admitted to the cardiology clinic from January 2014 to December 2016. Patients were divided into 4 groups as inferior group, anterior group, NSTEMI group, and UA group according to diagnosis. These groups were compared in terms of complications occurring after MI, TVCAD, and mortality rates. Results. There were significant differences in terms of complications forming after ACS, TVCAD, and mortality. The inferior subgroup had high PCT and MCHC levels and was found to have more complications developing and mortality compared to other groups. Patients with high PCT and MPV values were identified to have higher mortality and TVCAD. In the anterior subgroup, ischemic heart failure was higher compared to the other groups. In the interior, anterior, and non-ST elevated myocardial infarctus (NSTEMI) groups, the 0-, 6-, and 12-hour cTnI values were significantly higher compared to the UA group, while the anterior group had a significantly higher 12-hour cTnI value compared to the NSTEMI group. Correlation analysis for PCT, MCHC, and MPV with complications developing after MI, mortality, and TVCAD found positive and statistically significant correlations. Conclusion. High PCT, MCHC, and MPV levels in acute coronary syndrome may be beneficial predictive values in terms of complications that may develop, TVCAD, and mortality.

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“…13,14,30 By contrast, other previous reports state that myocardial infarction per se is associated with a significant release of PCT. 31,32 Moreover, PCT was proposed as a sensitive marker of myocardial damage as well as being associated with left ventricular remodeling and worse clinical outcome following infarction. 15,16,32 Taken together, these limited and controversial previous data cannot clarify the clinical significance of PCT in the setting of acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Association of Myocardial Injury With Serum Procalcitonin Levels in Patients With ST-Elevation Myocardial Infarction

et al. 2020

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IMPORTANCE Myocardial tissue injury due to acute ST-elevation myocardial infarction (STEMI) initiates an inflammatory response that leads to a release of systemic inflammatory biomarkers, including C-reactive protein (CRP) and white blood cells, consequently reducing the usefulness of these routine biomarkers for identifying concomitant infections. The clinical role of procalcitonin (PCT), a promising marker of bacterial infection, to detect concomitant infection in acute STEMI is unknown, mainly because it is unclear whether myocardial injury per se induces systemic PCT release. OBJECTIVE To investigate the release of serum PCT in the acute setting of STEMI (24 and 48 hours after primary percutaneous coronary intervention) and to elucidate any associations with myocardial injury markers through a comprehensive assessment by cardiac magnetic resonance (CMR) imaging. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study conducted between 2016 and 2018 included 141 consecutive patients with STEMI treated with primary percutaneous coronary intervention. Concentrations of PCT, high-sensitivity CRP (hs-CRP), and high-sensitivity cardiac troponin T (hs-cTnT) and white blood cell counts were measured serially 24 and 48 hours after infarct. EXPOSURES Acute STEMI and primary percutaneous coronary intervention. MAIN OUTCOMES AND MEASURES The association of PCT and typical inflammatory marker levels with CMR-determined myocardial damage was assessed. Infarct size, extent of microvascular obstruction, and occurrence of intramyocardial hemorrhage as determined by CMR within the first week following STEMI were also evaluated. RESULTS In total, 141 patients with STEMI (117 men [83%]) having a median age of 56 years (interquartile range, 50-66 years) were included. The median PCT concentration was 0.07 μg/L

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Procalcitonin in patients with acute coronary syndrome

Abstract: In conclusion, levels of hsCRP and procalcitonin are increased in patients with ACS but failed to correlate with severity of coronary disease and early prognosis.

Cited by 27 publications

References 0 publications

Nomogram Based on Cytokines for Cardiovascular Diseases in Xinjiang Kazakhs

Nomogram Based on Cytokines for Cardiovascular Diseases in Xinjiang Kazakhs

Do MCHC, MPV, and Procalcitonin Levels Determine Prognosis in Acute Coronary Syndrome?

Association of Myocardial Injury With Serum Procalcitonin Levels in Patients With ST-Elevation Myocardial Infarction

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