Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection

Prat, Cristina; Domínguez, J.; Corrêa-Oliveira, Rodrigo; Giménez, M.D.; Azuara, Marta; Jiménez, Orlando; Espelt, Núria Galí; Ausina, V.

doi:10.1097/01.inf.0000095197.72976.4f

Cited by 98 publications

(65 citation statements)

References 27 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The serum level of PCT was measured by using an enzyme-linked fluorescence assay (VIDAS � BRAHMS PCT assay; Biomerieux, Lyon, France), according to the manufacturer' s instructions; the detection limit of this assay is 0.05 ng/mL. The upper limit of reference interval used in this study was 0.5 ng/mL, as suggested by the manufacturer, whereas the upper limits for elevated serum PCT level were 1.0 ng/mL, which has been suggested by Moulin et al [8], and 2.0 ng/mL, which has been suggested by Toikka et al [9] and Prat et al [15].…”

Section: Measurement Of Pct Level Crp Level Esr and Wbc Countmentioning

confidence: 74%

Clinical Significance of Serum Procalcitonin in Patients with Community-acquired Lobar Pneumonia

et al. 2010

View full text Add to dashboard Cite

Section: Measurement Of Pct Level Crp Level Esr and Wbc Countmentioning

confidence: 74%

Clinical Significance of Serum Procalcitonin in Patients with Community-acquired Lobar Pneumonia

et al. 2010

View full text Add to dashboard Cite

“…Others have found sensitivity and specificity values for procalcitonin in similar ranges (Table 3) [2,5,11,14,21,26,29,30,33]. However, the results reported by Worthington et al were quite different: serum procalcitonin did not help distinguish between infectious and noninfectious causes of prosthetic hip loosening [41].…”

Section: Discussionmentioning

confidence: 91%

“…We specified the following exclusion criteria: patients with inflammation other than an orthopaedic infection (eg, autoimmunity, intercurrent febrile infection) (to avoid interference with other inflammatory processes); patients with other possible preconditions for elevated inflammatory markers, such as chronic inflammatory diseases, obesity (BMI [ 30), viral infections, malignancies, or heavy smoking; and patients with renal, hepatic failure, or deficiencies of the immune system. Patients were recruited between March 2008 and June 2010 in the Department for Orthopaedic Surgery, Medical University of Graz (Graz, Austria).…”

Section: Methodsmentioning

confidence: 99%

“…Numerous studies have shown procalcitonin is elevated in cases of bacterial infection or sepsis and levels are considerably higher in bacterial infections than in viral infections [2,5,11,14,21,26,29,30,33]. Procalcitonin increases 2 to 4 hours after the onset of sepsis, which is later than proinflammatory cytokines, such as interleukin 6 (IL-6), but considerably earlier than CRP [31].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Biomarkers to Detect Infection in Revision Hip and Knee Arthroplasties

Glehr

Friesenbichler

Hofmann

et al. 2013

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background A periprosthetic joint infection is one of the most challenging complications associated with THA and TKA. In the diagnostic process for detecting a periprosthetic joint infection, one of the most important steps is analysis of laboratory infection biomarkers. Questions/purposes We investigated the sensitivity and specificity of the biomarkers procalcitonin, interleukin 6 (IL-6), and interferon a (IFN-a) as compared with conventional biomarkers (C-reactive protein [CRP], leukocyte level) for a periprosthetic joint infection associated with revision arthroplasties. Methods We prospectively included and analyzed 84 patients (124 revision arthroplasties). The blood parameters of interest were procalcitonin, IL-6, IFN-a, leukocyte level, and CRP. Samples were taken preoperatively and on the first, third, and seventh postoperative days. The sensitivity and specificity of these biomarkers then were calculated. Results Considering the preoperative values of 84 patients (124 operations), procalcitonin, IL-6, CRP, and leukocyte level correlated with periprosthetic joint infection, whereas IFN-a did not. A procalcitonin cut-off level of 0.35 ng/mL revealed a sensitivity of 80% and specificity of 37%. An IL-6 cut-off level of 2.55 pg/mL had a sensitivity of 92% and specificity of 59%. Conclusions In this study procalcitonin and IL-6 were helpful for detecting periprosthetic joint infections in revision arthroplasties, although CRP generally was superior. Procalcitonin and IL-6 may be considered adjuvant tests when the diagnosis of a periprosthetic joint infection is in doubt. This study showed, in addition to conventional biomarkers such as CRP and leukocyte level, procalcitonin and IL-6 were helpful for detecting infections associated with revision arthroplasties.

show abstract

“…[7][8][9] The highest value is seen in association with gram-negative sepsis and bacterial meningitis; levels increase moderately when local bacterial infections such as pyelonephritis and pneumonia are present. [10][11][12] Some studies showed that a high PCT level in patients with Plasmodium falciparum malaria correlate with severity and poor prognosis of the disease. 13 To our knowledge, PCT serum levels have not been evaluated in VL patients.…”

mentioning

confidence: 99%

Evaluation of Serum Procalcitonin Levels for Diagnosis of Secondary Bacterial Infections in Visceral Leishmaniasis Patients

Pasyar

Alborzi²,

Pouladfar³

2012

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Secondary bacterial infections are a major complication and cause of death in children with visceral Leishmaniasis (VL). Thus, early diagnosis of bacterial infections is an important step in the treatment of patients with VL. The goal of this study was to determine if serum procalcitonin (PCT) could be used as a diagnostic marker of secondary bacterial infections in VL patients. Serum PCT was measured in 35 hospitalized patients with VL before treatment and after defervescence. The level was higher than normal (> 0.5 ng/mL) in 72% (25) of the patients. Twelve (34%) of 35 patients had secondary bacterial infections with PCT levels ranging from 0.1 to 12.29 ng/mL, and those without secondary bacterial infections (23) had PCT levels ranging from 0.1 to 14.58 ng/mL. The results suggest that PCT levels increase significantly in most VL patients but are not correlated with the presence of secondary bacterial infections.

show abstract

Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection

Cited by 98 publications

References 27 publications

Clinical Significance of Serum Procalcitonin in Patients with Community-acquired Lobar Pneumonia

Clinical Significance of Serum Procalcitonin in Patients with Community-acquired Lobar Pneumonia

Novel Biomarkers to Detect Infection in Revision Hip and Knee Arthroplasties

Evaluation of Serum Procalcitonin Levels for Diagnosis of Secondary Bacterial Infections in Visceral Leishmaniasis Patients

Contact Info

Product

Resources

About