Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children

Shaikh, Kai; Osio, Victor A.; Leeflang, Mariska; Shaikh, Nader

doi:10.1002/14651858.cd009185.pub3

Cited by 34 publications

(25 citation statements)

References 169 publications

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“…In children with UTI, sensitivity of CRP (cut-off 20 mg/L) and PCT (cut-off 0.5 ng/mL) in predicting pyelonephritis is high (94% and 86%, respectively), but specificity varies (39% and 74%, respectively)) 28. However, the number of studies in this systematic review was limited and the heterogeneity substantial.…”

Section: Introductionmentioning

confidence: 93%

Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol

et al. 2019

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IntroductionSuspected urinary tract infection (UTI) ranks among the most common reasons for antibiotic use in nursing homes. However, diagnosing UTI in this setting is challenging because UTI often presents with non-specific symptomatology. Moreover asymptomatic bacteriuria is common in elderly, which complicates attribution of causality to detection of bacteria in urine. These diagnostic challenges contribute to overuse of antibiotics and emergence of antimicrobial resistance in nursing homes. Given the diagnostic challenges, there is a need for point-of-care (POC) diagnostic tests to support clinical rules for diagnosing UTI. Procalcitonin (PCT) and C reactive protein (CRP) are inflammatory blood markers that have been proven useful to support diagnosis and monitoring of (bacterial) respiratory tract infections and sepsis. While limited studies suggest their usefulness in supporting UTI diagnosis, their utility has not been studied in elderly populations for this purpose.Methods and analysisIn a 24-month matched prospective study, ‘PROGRESS’ will assess and compare the sensitivity of rapid POC measurements of blood CRP and PCT levels to support clinical rules for diagnosing UTI in nursing home residents. The primary outcome measure is sensitivity of the POC tests to identify patients with true UTI based on the predefined definition, as derived from receiver operating curves.Ethics and disseminationThis study will be conducted in accordance with Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The study protocol is approved by the Medical Ethical Committee of Amsterdam UMC location VUmc with reference number 2017.350 and National Central Committee on Research involving Human Subjects with reference number NL62067.029.17.Trial registration numberNTR6467.

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Section: Introductionmentioning

confidence: 93%

Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol

et al. 2019

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“…(), 53 Hooper et al. (), 54 Shaikh, Borrell, Evron and Leeflang (), 55 Shaikh, Spingarn and Hum (), 56 Schmidt‐Hansen et al. (), 57 Walsh et al.…”

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lilacs search strategy for systematic reviews of diagnostic test accuracy studies

Pereira

Puga

Atallah

et al. 2019

Health Info Libraries J

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Background There are few publications on search strategies to identify diagnostic test accuracy (DTA) studies in lilacs. Objective To translate and customise medline search strategies for use in lilacs and assess their retrieval of studies in Cochrane DTA systematic reviews. Method We developed a six‐step process to translate and customise medline search strategies for use in lilacs (iAHx interface). We identified medline search strategies of published Cochrane DTA reviews, translated/customised them for use in lilacs, ran searches in lilacs and compared the retrieval results of our translated search strategy versus the one used in the published reviews. Results Our lilacs search strategies translated/customised from the medline strategies retrieved studies in 70 Cochrane DTA reviews. Only 29 of these reviews stated that they had searched the lilacs database and 21 published their lilacs search strategies. Few had used the lilacs database search tools, none exploded the subject headings, and 86% used only English terms. Conclusion Translating and tailoring a medline search strategy for the lilacs database resulted in the retrieval of DTA studies that would have been missed otherwise.

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“…The composite urinalysis and moderate or large leukocyte esterase both had good negative predictive values for the outcome of UTI [12]. According to the procalcitonin, CRP against the results of acute-phase DMSA scan in children aged 0 to 18 years with culture confirmed episode of UTI, the cutoff values were used for the primary analysis of UTI: 0.5mg/mL for procalcitonin, 20mg/L for CRP [13]. Moreover, certain unopathogens: Enterococcus species, Klebsiella species, and Psiudomonas aeruginosa were less likely to exhibit pyuria (>/=5 WBCs per high power field or >/=10 WBCs per cubic millimeter) [14].…”

Section: Discussionmentioning

confidence: 99%

The Possibility of Urinary Tract Infection in Primary School Students with A Diagnosis of Febrile Pharyngotonsillitis

Huang

Tsang³

et al. 2018

BJSTR

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Background: Urinary tract infection (UTI) is one of the commonest bacterial infection seen in children, ranking second only to those of the respiratory tract. Material & Methods:One hundred and five 6-12 years old school children with pharyngotonsillitis visit our outpatient clinic were recruited in this study. Urinalysis and mid-stream urine collection culture after disinfection of the private area were performed in all children. Serum procalcitonin, CRP and DMSA were performed in student with significant positive urine culture. Results:The urine culture results showed positive rate in 48.6%, negative rate in 39% and contamination urine culture was 12.4%. Urinalysis did not indicate the possibility of positive urine culture. Also, the procalcitonin and CRP could not indicate upper UTI when compared with the results of DMSA. Conclusion:This study indicates that urine tract evaluation is important and should be performed in children who are suspected with pharyngotonsillitis.

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Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children

Abstract: Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children (Review)

Cited by 34 publications

References 169 publications

Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol

Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol

lilacs search strategy for systematic reviews of diagnostic test accuracy studies

The Possibility of Urinary Tract Infection in Primary School Students with A Diagnosis of Febrile Pharyngotonsillitis

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