Procalcitonin as a Predictive Marker for Bacteremia in Children With a Central Line and Fever

Damman, Jennifer; Arias, Patricio; Kerner, John A.; Zhang, Ke-You; Dehghan, Melody; Krishnan, Gomathi; Nespor, Colleen; Bensen, Rachel; Park, K.T.

doi:10.1542/hpeds.2018-0123

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…Another study conducted a ROC analysis for comparing the predictive abilities of various factors for bacterial infection. They found that maximum PCT value had the highest AUC value, indicating its superior predictive ability [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Prognosis prediction of procalcitonin within 24 h for acute diquat poisoning

He,

Liang,

Zhang

et al. 2024

BMC Emerg Med

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Background To explore the predictive value of procalcitonin (PCT) within 24 h after poisoning for prognosis of acute diquat poisoning. Methods This retrospective study included acute diquat poisoning patients in the Nanyang City Hospital between May 2017 and July 2021. Results Among the 45 patients included, 27 survived. The maximum PCT value within 24 h after poisoning was significantly higher in the non-survival patients [9.65 (2.63, 22.77) vs. 0.15 (0.10, 0.50) µg/mL, P < 0.001] compared to the survival patients. The area under the ROC curve (AUC) indicated that the maximum PCT value within 24 h had a good predictive value (AUC = 0.905, 95% CI: 0.808-1.000) compared to ingested quantity (AUC = 0.879, 95% CI: 0.776–0.981), serum creatinine (AUC = 0.776, 95% CI: 0.640–0.912), or APACHE II score (AUC = 0.778, 95% CI: 0.631–0.925). The predictive value of maximum PCT value within 24 h was comparable with blood lactate (AUC = 0.904, 95%CI: 0.807-1.000). Conclusions The maximum PCT value within 24 h after poisoning might be a good predictor for the prognosis of patients with acute diquat poisoning.

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Section: Discussionmentioning

confidence: 99%

Prognosis prediction of procalcitonin within 24 h for acute diquat poisoning

He,

Liang,

Zhang

et al. 2024

BMC Emerg Med

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“…Damman et al sought for the diagnostic accuracy of PCT in predicting bacteremia in febrile children with indwelling central lines (90). They reported that a PCT level of >=0.6 ng/mL was the best cutoff point with a sensitivity of 85.6% and a specificity of 66% (AUC 0.85) which approved PCT as a sensitive biomarker predicting bacteremia in febrile children with a central line.…”

Section: Use Of Pct In Childrenmentioning

confidence: 99%

Diagnostic and Prognostic Roles of Procalcitonin and Other Markers in Pneumonia: A Literature Update

OZBAY¹,

AYAN²,

Karcıoğlu³

2023

Preprint

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Community-acquired pneumonia (CAP) is among the most common causes of death and one of the leading healthcare concerns worldwide. It can evolve into sepsis and septic shock, which have a high mortality rate, especially in critical patients and comorbidities. The definitions of sepsis were revised in the last decade as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Procalcitonin (PCT), C-reactive protein (CRP), and complete blood count including white blood cells are among the most commonly analyzed sepsis-specific biomarkers also used in pneumonia in a broad range of studies. It appears to be a reliable diagnostic tool to expedite care of these patients with severe infections in the acute setting. PCT was found superior to most other acute phase reactants and indicators, including CRP as a predictor of pneumonia, bacteremia, sepsis and poor outcome. In addition, PCT use is beneficial to judge timing for cessation of antibiotic treatment in most severe infectious states. The clinicians should be aware of strengts and weaknesses of known and potential biomarkers in expedient recognition and management of severe infections. This manuscript is intended to present an overview of the definitions, complications and outcomes of CAP and sepsis, with special regard to PCT and other important markers.

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“…There are fewer data to support the use of PCT use in meningitis or in infectious complications of trauma, burns and pancreatitis [11]. Recent studies have evaluated the role of PCT in identifying bacterial infection in children with pneumonia, musculoskeletal infection, central line and fever and urinary tract infections, with varying utility of PCT to predict bacterial vs. non-bacterial infection [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections

et al. 2020

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Introduction: The kinetics of procalcitonin in pediatric patients with non-critical acute bacterial infections receiving appropriate antibiotic therapy are not well described. Methods: We performed a single-center, prospective observational pilot study of children admitted to a tertiary care children's hospital who were receiving antibiotics for treatment of a non-critical acute bacterial infection, and we prospectively measured serial procalcitonin levels daily for 4 days during hospitalization. Results: Among the 46 children with baseline procalcitonin levels enrolled in the study, procalcitonin kinetics followed a half-life of approximately 24 h in most patients. Procalcitonin declined faster than C-reactive protein over the first 48 h of appropriate antibiotic treatment. There was variation in biomarker levels among participants with the same infection type, especially in participants with bacteremia, musculoskeletal infection and skin/soft tissue infection. Conclusion: Utility of procalcitonin as a biomarker to follow every 24-48 h in non-critically ill children receiving antibiotic therapy for bacterial infections as an objective measure of clinical improvement is promising.

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Procalcitonin as a Predictive Marker for Bacteremia in Children With a Central Line and Fever

Cited by 8 publications

References 15 publications

Prognosis prediction of procalcitonin within 24 h for acute diquat poisoning

Prognosis prediction of procalcitonin within 24 h for acute diquat poisoning

Diagnostic and Prognostic Roles of Procalcitonin and Other Markers in Pneumonia: A Literature Update

Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections

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