PROCALCITONIN AND CGRP-I mRNA EXPRESSION IN VARIOUS HUMAN TISSUES

Rußwurm, Stefan; Stonâns, Ilmars; Stonane, Elita; Wiederhold, Matthias; Luber, Andrea; Zipfel, Peter F.; Deigner, Hans‐Peter; Reinhart, Konrad

doi:10.1097/00024382-200116020-00004

Cited by 87 publications

(60 citation statements)

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“…Calcitonin gene-related peptide is associated with the acute phase response (Russwurm et al 2001). Our results show for the first time that the concentration of plasma CGRP was higher in control cows than in fatty-liver cows after calving.…”

Section: Discussionmentioning

confidence: 51%

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Ametaj¹,

Bradford²,

Bobe³

et al. 2005

Can. J. Anim. Sci.

152

126

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. 2005. Strong relationships between mediators of the acute phase response and fatty liver in dairy cows. Can. J. Anim. Sci. 85: [165][166][167][168][169][170][171][172][173][174][175]. The objective of this study was to investigate the relationship between activation of acute phase response and fatty liver in transition dairy cows. Fatty liver was induced in dairy cows by feeding 8 kg of cracked corn 1 mo before the expected day of parturition. Liver and blood samples were obtained at days -4, 3, 8, 12, 14, 22, 27, and 36 postpartum. Cows that developed fatty liver (n = 4) reached peak total lipids in the liver at day 12 postpartum with 11.4% (wet wt.) compared with 6.6% in control cows (n = 4). Cows with fatty liver had greater plasma tumor necrosis factor-alpha (TNF-α), nonesterified fatty acids (NEFA), and lower lactate concentrations than did control cows at day -4. During highest concentrations of total lipids in the liver, for at least one time-point, fatty-liver cows had greater concentrations of plasma serum amyloid A (SAA), haptoglobin, and NEFA and lower concentrations of calcitonin gene-related peptide (CGRP), prostaglandin E 2 (PGE 2 ), cortisol, and TNF-α than did control cows. Concentrations of total lipids in the liver at 12 d postpartum were correlated (a) positively with plasma TNF-α, SAA, and NEFA and negatively with plasma CGRP before calving, (b) positively with plasma SAA, haptoglobin, and NEFA and negatively with plasma PGE 2 , CGRP, total cholesterol, and glucose at days 3, 8, and 12 postpartum, and (c) negatively with concentrations of plasma glucose, lactate, and total bilirubin after day 12 postpartum. In conclusion, this study indicates that the acute phase response occurs in cows with fatty liver as well as strong relationships between mediators of immune response and fatty liver. Mots clés: Réponse phase aiguë, foie gras, vaches laitièresFatty liver is a common metabolic disorder that affects almost half of all dairy cows immediately after parturition.Despite much progress in understanding metabolic events during the development of fatty liver, the precise mechanisms of the pathology remain unclear. The conventional view is that fatty liver is characterized by excess liver triacylglycerols (TAG) arising from a negative energy balance after parturition (Bauchart et al. 1998). The negative energy balance evokes a major mobilization of non-esterified fatty acids (NEFA) from adipose tissue and increased uptake of

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Section: Discussionmentioning

confidence: 51%

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Ametaj¹,

Bradford²,

Bobe³

et al. 2005

Can. J. Anim. Sci.

152

126

View full text Add to dashboard Cite

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“…Unexpectedly, proCT levels were elevated even in septic, thyroidectomized patients (Assicot et al, 1993), suggesting that the majority of proCT are secreted from cells other than thyroid C-cells. Whereas blood mononuclear cells and the liver are candidate sites of origin of proCT in mammals (Russwurm et al, 2001;Whicher et al, 2001), rainbow trout pro-sCT-I might be secreted from the gills. However, the physiological role of proCT is not yet known in fish.…”

Section: Discussionmentioning

confidence: 99%

Shift of Chloride Cell Distribution during Early Life Stages in Seawater-Adapted Killifish, Fundulus heteroclitus

et al. 2000

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“…In this connection, it is of interest that very high levels of serum procalcitionin is present in patients with severe systemic inflammation and sepsis, and this finding is used as a clinical marker for systemic infection responses (Assicot et al 1993;Dandona et al 1994;Russwurm et al 1999). Although the cellular sources of the high levels of serum procalcitonin have not been fully identified, various cells, including blood mononuclear cells, are presumed to secrete the procalcitonin (Russwurm et al 2001). Therefore, it is important to identify the precise cellular sites at which procalcitonin is synthesized during inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

Expression and Localization of Prohormone Convertase PC1 in the Calcitonin-producing Cells of the Bullfrog Ultimobranchial Gland

Yaoi

Suzuki

Tomura

et al. 2003

J Histochem Cytochem.

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(YS) S U M M A R Y We examined the expression and localization of the prohormone convertases, PC1 and PC2, in the ultimobranchial gland of the adult bullfrog using immunohistochemical (IHC) and in situ hybridization (ISH) techniques. In the ultimobranchial gland, PC1-immunoreactive cells were columnar, and were present in the follicular epithelium. When serial sections were immunostained with anti-calcitonin, anti-CGRP, anti-PC1, and anti-PC2 sera, PC1 was found only in the calcitonin/CGRP-producing cells. No PC2-immunopositive cells were detected. In the ISH, PC1 mRNA-positive cells were detected in the follicle cells in the ultimobranchial gland. No PC2 mRNA-positive cells were detected. RT-PCR revealed expression of the mRNAs of PC1 and the PC2 in the ultimobranchial gland. However, very little of the PC2 mRNA is probably translated because no PC2 protein was detected either by IHC staining or by Western blotting analysis. We conclude that the main prohormone convertase that is involved in the proteolytic cleavage of procalcitonin in the bullfrog is PC1. (J Histochem

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PROCALCITONIN AND CGRP-I mRNA EXPRESSION IN VARIOUS HUMAN TISSUES

Cited by 87 publications

References 0 publications

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Strong relationships between mediators of the acute phase response and fatty liver in dairy cows

Shift of Chloride Cell Distribution during Early Life Stages in Seawater-Adapted Killifish, Fundulus heteroclitus

Expression and Localization of Prohormone Convertase PC1 in the Calcitonin-producing Cells of the Bullfrog Ultimobranchial Gland

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