Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either Gram-negative or Gram-positive bacteria

Liu, H. H.; Zhang, M. W.; Guo, Jianxing; Li, J.; Ling, Su

doi:10.1007/s11845-016-1457-z

Cited by 55 publications

(44 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These confounding factors were not excluded in this study. Hence, CRP levels were considered inferior to PCT levels in distinguishing causative pathogens of sepsis [28]. In our study, CRP levels were significantly higher in GN and fungal sepsis, but they were low in GP sepsis (Table 2).…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Procalcitonin, c-reactive protein, leukocyte, mean platelet volume levels in bloodstream infections

İrvem¹

2018

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: Levels of Serum Procalcitonin (PCT), C-Reactive Protein (CRP), Leukocyte (WBC) and Mean Platelet Volume (MPV) were evaluated in sepsis patients. We evaluated the diagnostic accuracy of different inflammatory markers to discriminate sepsis caused by different pathogens. Material and Method: In this study we included 126 episodes of bacteremia from 126 patients with sepsis. Medical records of patients who had bacteremia caused by Gram-negative bacteria (GN), Gram-positive bacteria (GP) or yeast were reviewed, and information about PCT and other inflammatory markers was recorded. Mann-Whitney U test and Spearman's correlation analysis were used for statistical analysis. Results: 60.4% of the cases (n=76) were GN, 31.7% (n=40) were GP and 7.9% (n=10) were yeast. There was a statistically significant difference between PCT, CRP, and MPV levels according to the microorganism (p=0.001, p<0.01). There was no statistically significant difference between WBC measurements according to the microorganism (p>0.05). Discussion: According to the microorganism, gram positivity cutoff points were determined for PCT as (≤12.17), CRP as (≤9.70) and MPV as (≤9.32). In bilateral comparisons, there was a significant increase in GN and yeast sepsis, while a significantly low level was found in GP sepsis. There was no significant difference between GN and yeast. When the measurements of PCT according to bacterial species are examined, the highest measurement was 44.6 ng/ml with Escherichia coli bacteria, followed by Candida bacteria with 12.6 ng/ml.

show abstract

Section: Discussionmentioning

confidence: 53%

“…In one study, serum PCT levels were higher in GN sepsis than GP sepsis in 72 h. There were no differences in CRP levels. The separation of PCT and CRP phenomenon is helpful for early diagnosis of GP sepsis [28]. These confounding factors were not excluded in this study.…”

Section: Discussionmentioning

confidence: 96%

Procalcitonin, c-reactive protein, leukocyte, mean platelet volume levels in bloodstream infections

İrvem¹

2018

Ann Clin Anal Med

View full text Add to dashboard Cite

show abstract

“…23,24 They have consistently reported higher median serum PCT levels in Gram negative bacteremia as compared to Gram positive bacteremia. The ROC curves demonstrated discriminatory ability between the two types of bacteremia.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Accuracy of Serum Procalcitonin for Bacteremia in Critically Ill Children

Nellis

Pon

Giambrone

et al. 2016

Infect Dis Clin Pract

View full text Add to dashboard Cite

Background Bacterial sepsis is frequently encountered in children admitted to the Pediatric Intensive Care Unit (PICU) and requires early recognition and treatment. Procalcitonin (PCT) is a serum biomarker with a high sensitivity to predict bacteremia in critically-ill adults. This study sought to evaluate the diagnostic accuracy of PCT for bacteremia in febrile children in the PICU. Methods This retrospective observational study used data from children admitted to the PICU from October 2010 to October 2012. Patients up to 21 years of age were included if they had an abnormal temperature, serum PCT and blood culture assayed, and were not receiving empiric antibiotics at the time. Results There were 202 PCT values that met inclusion criteria. The prevalence of positive blood cultures was 13.2% (27 total positive blood cultures). The area under the curve (AUC) for PCT was 0.79 (95% CI, 0.70-0.89), the AUC for lactate was 0.76 (95% CI, 0.65-0.87), and the AUC for C-reactive protein was 0.68 (95% CI, 0.57-0.80). The optimal threshold of PCT for accuracy was determined to be 2 ng/mL (sensitivity = 69.2%, specificity = 74.4%, positive predictive value = 28.6%, negative predictive value = 94.2%). The combination of an abnormal lactate (> 2.0mmol/L) increased the specificity of PCT for diagnosing bacteremia. Conclusions PCT has a good diagnostic accuracy to rule-out bacteremia in critically-ill, febrile children. The combination of PCT and an abnormal lactate value increases the specificity and may improve the ability to diagnose bacteremia.

show abstract

“…En pacientes inmunocomprometidos neutropénicos se ha descrito Sens del 66% y Esp del 78% de la PCT para diagnóstico de bacteriemia 18 . Nuestro estudio tiene la ventaja de aportar datos de una población especialmente vulnerable.…”

Section: Discussionunclassified

“…Las causas de altos niveles de PCT sin infección incluyen: politrauma, cirugía mayor, choque cardiogénico y la presencia de metástasis o carcinoma con un componente neuroendocrino, que deben considerarse como limitaciones de este biomarcador 14,18 .…”

Section: Discussionunclassified

Procalcitonina como predictor temprano de bacteriemia en pacientes neutropénicos críticamente enfermos

Marin¹,

Unigarro²,

Basantes³

et al. 2020

GAMO

View full text Add to dashboard Cite

Artículo originAl resumen Antecedentes: La procalcitonina (PCT) podría predecir la presencia de bacteriemia en pacientes críticos con neutropenia febril. El objetivo del estudio fue determinar el valor predictivo de la PCT en el diagnóstico de bacteriemia y su capacidad de diferenciar gérmenes gramnegativos y grampositivos. Métodos: Estudio de cohorte retrospectivo realizado en el Hospital Oncológico Solón Espinosa Ayala, Quito-Ecuador, que incluyó todos los pacientes adultos que ingresaron con neutropenia febril a la terapia intensiva. Se evaluaron los valores de PCT al ingreso junto con muestras de hemocultivos, desde el año 2010 al 2016. resultados: En 117 pacientes se investigó la asociación entre niveles de PCT y el diagnóstico de bacteriemia, la PCT demostró discriminación de bacteriemia, punto de corte de 15.5 ng/ml y un área bajo la curva (AUC) de 0.76 en la curva ROC (curva operador-receptor). La concentración de PCT en pacientes con bacteriemia por gérmenes gramnegativos fue mayor comparada con pacientes con bacteriemias por gérmenes grampositivos, 26 vs. 7.1 ng/ml (p = 0.001). Valores mayores a 26.8 ng/ml predicen bacteriemia por bacilos gramnegativos (AUC: 0.81). conclusiones: En pacientes neutropénicos febriles críticos, un valor de corte de PCT mayor a 15.5 ng/ml es un predictor de bacteriemia (AUC: 0.76) y valores mayores a 26.8 ng/ml predicen bacteriemia por bacilos gramnegativos (AUC: 0.81).

show abstract

Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either Gram-negative or Gram-positive bacteria

Abstract: Serum PCT levels are higher in GN sepsis than GP sepsis in 72 h. There are not differences in CRP. The separation of PCT and CRP phenomenon is helpful for early diagnosis of GP sepsis.

Cited by 55 publications

References 22 publications

Procalcitonin, c-reactive protein, leukocyte, mean platelet volume levels in bloodstream infections

Procalcitonin, c-reactive protein, leukocyte, mean platelet volume levels in bloodstream infections

The Diagnostic Accuracy of Serum Procalcitonin for Bacteremia in Critically Ill Children

Procalcitonina como predictor temprano de bacteriemia en pacientes neutropénicos críticamente enfermos

Contact Info

Product

Resources

About