Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome

Mimoz, Olivier; Édouard, A.; Samii, Kamran; Benoist, J.-F.; Assicot, M.; Bohuon, C

doi:10.1007/s001340050543

Cited by 244 publications

(151 citation statements)

References 18 publications

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“…We used blood levels of C-reactive protein (CRP), PCT, white blood cell count (WBC) and pro-adrenomedullin (ProADM) from the day of admission and days 3, 5 and 7 to reflect the inflammatory response. These markers are upregulated during systemic infections and correlate with inflammation (CRP, WBC), bacterial aetiology (PCT) and disease severity/mortality and other adverse outcome risk (ProADM) [18][19][20][21][22]. For the purpose of this study, we defined 'adverse clinical course' as all-cause mortality, intensive-care unit (ICU) admission, or both, during a 30 day follow-up.…”

Section: Methodsmentioning

confidence: 99%

Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study

et al. 2013

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Aims/hypothesis Despite the condition's high prevalence, the influence of hyperglycaemia on clinical outcomes in noncritical-care inpatients with infections remains ill defined. In this study, we analysed associations of glucose levels at admission and during initial inpatient treatment with the inflammatory response and clinical outcome in communityacquired pneumonia (CAP) patients. Methods This secondary observational analysis included 880 confirmed CAP patients. We used severity-adjusted multivariate regression models to investigate associations of initial and 96 h mean glucose levels with serially measured biomarker levels over 7 days (C-reactive protein [CRP], procalcitonin, white blood cell count [WBC], pro-adrenomedullin [ProADM]) and adverse clinical course (death and intensivecare unit admission). Results In the 724 non-diabetic patients (82.3% of the study population), moderate or severe hyperglycaemia (glucose 6-11 mmol/l and >11 mmol/l, respectively) was associated with increased risk for adverse clinical course (adjusted OR [95% CI] 1.4 [0.8, 2.4] and 3.0 [1.1, 8.0], respectively) and with higher CRP, WBC and ProADM levels over 7 days (p <0.05, ANOVA, all days). In diabetic patients (n =156), no similar associations were found for initial hyperglycaemia, although mean 96 h glucose levels ≥9 mmol/l were associated with adverse clinical course (adjusted OR 5.4 [1.1, 25.8]; p =0.03). No effect modification by insulin treatment was detected (interaction terms p >0.2 for all analyses). Conclusions/interpretation Initial hyperglycaemia in nondiabetic CAP patients, and prolonged hyperglycaemia in diabetic or non-diabetic CAP patients, are associated with a more pronounced inflammatory response and CAP-related adverse clinical outcome. Optimal glucose targets for insulin treatment of hyperglycaemia in non-critical-care settings should be defined.

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Section: Methodsmentioning

confidence: 99%

Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study

et al. 2013

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“…Serum procalcitonin (PCT)-a marker of septicemia and infection severity [2]-has also been proposed as an indicator of systemic inflammatory response in noninfectious situations [3,4]. As no data exist thus far on PCT in stroke, this study aimed to evaluate serum PCT changes in the acute stroke setting, and to correlate them with clinical and laboratory parameters and patient's outcome.…”

Section: To the Editormentioning

confidence: 99%

“…At presentation and at day 7, the Glascow Coma Scale (GCS), the National Institute of Health Stroke Scale (NIHSS), and the Acute Physiology And Chronic Health Evaluation (APACHE) II score (only on admission) were performed, and full blood count, fibrinogen, C-reactive protein (CRP), glucose, urea, creatinine, electrolytes, albumin, total protein, lipids, creatine kinase (CK), lactate dehydrogenase (LDH) and PCT were measured. PCT was also measured on days 2, 3 and 4, since serum PCT levels reach their peak between 48 and 72 h [3,4]. An axillary temperature measurement was taken every 3 h in all patients.…”

Section: To the Editormentioning

confidence: 99%

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Serial serum procalcitonin changes in the prognosis of acute stroke

Miyakis

Georgakopoulos

Kiagia

et al. 2004

Clinica Chimica Acta

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“…This indicates that the degree of the inflammatory response is different depending on aetiology [38][39][40][41].…”

Section: Sepsis Is Different In Surgical and Medical Patientsmentioning

confidence: 99%

Can procalcitonin levels indicate the need for adjunctive therapies in sepsis?

Becze¹,

Molnár

Fazakas

2015

International Journal of Antimicrobial Agents

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a b s t r a c tAfter decades of extensive experimental and clinical research, septic shock and the related multiple organ dysfunction still remain the leading cause of mortality in intensive care units (ICUs) worldwide. Defining sepsis is a difficult task, but what is even more challenging is differentiating infection-induced from non-infection-induced systemic inflammatory response-related multiple organ dysfunction. As conventional signs of infection are often unreliable in intensive care, biomarkers are used, of which one of the most frequently investigated is procalcitonin. Early stabilisation of vital functions via adequate supportive therapy and antibiotic treatment has resulted in substantial improvements in outcome over the last decades. However, there are certain patients who may need extra help, hence modulation of the immune system and the host's response may also be an important therapeutic approach in these situations. Polyclonal intravenous immunoglobulins have been used in critical care for decades. A relatively new potential approach could be attenuation of the overwhelming cytokine storm by specific cytokine adsorbents. Both interventions have been applied in daily practice on a large scale, with firm pathophysiological rationale but weak evidence supported by clinical trials. The purpose of this review is to give an overview on the pathophysiology of sepsis as well as the role and interpretation of biomarkers and their potential use in assisting adjunctive therapies in sepsis in the future.

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Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome

Cited by 244 publications

References 18 publications

Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study

Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study

Serial serum procalcitonin changes in the prognosis of acute stroke

Can procalcitonin levels indicate the need for adjunctive therapies in sepsis?

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