Procalcitonin: A Novel Cardiac Marker with Prognostic Value in Acute Coronary Syndrome

Ataoğlu, HE; Yılmaz, Fatih; Uzunhasan, Işıl; Çetin, Faik; Temiz, Lü; Döventaş, Y.E.; Kaya, Ayşem; Yenigün, Mustafa

doi:10.1177/147323001003800106

Cited by 34 publications

(26 citation statements)

References 27 publications

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“…An increase in high arterial BPs, correlating with an increase in CRP, emphasize the importance of PCT in an early diagnosis of atherosclerosis. 32 In the study by Schiopu et al, 33 it was seen that most of the patients with high PCT levels developed acute coronary syndrome and cerebrovascular disease, and some patients even died, although they did not have CVD at the beginning. There were strong positive correlations between PCT and CRP in the HT group, and PCT and CIMT in both HT and WCH groups.…”

Section: Discussionmentioning

confidence: 97%

Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension

et al. 2015

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An association has been described between inflammation and the progression of hypertension (HT) and is shown with several biochemical parameters. Our aim was to examine the distribution of the serum procalcitonin (PCT), pentraxin (PTX)-3 and interleukin (IL)-33 levels and their relationship with carotid intima-media thickness (CIMT) in subjects with white coat HT (WCH), HT and normotension (NT) groups. Thirty-three patients with HT, 33 patients with WCH and 33 healthy subjects were enrolled in this study. PCT, PTX-3 and C-reactive protein (CRP) levels significantly increased in the HT group compared with the NT group. In addition, PCT and CRP levels were significantly higher in the WCH group than in the NT group. CIMT measurements were significantly higher in the WCH and HT groups than in the NT group. In the HT and WCH groups, there were significant positive correlations between PTX-3, PCT and CRP. In the WCH group, PTX-3 and PCT levels were significantly positively correlated with CIMT. PCT had area under the curve value of 0.817 which demonstrates its sufficiency to distinguish WCH from NT individuals. Our results suggest that in subjects with WCH and HT, which are characterized by increased cardiovascular risk, PTX-3 and PCT levels in the HT group and PCT levels in the WCH group are significantly and consistently higher than normotensives. Systemic inflammation moderately occurs in the WCH and HT groups. PCT monitoring may be a useful biomarker in inflammation related to atherosclerosis and early stage HT.

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Section: Discussionmentioning

confidence: 97%

Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension

et al. 2015

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“…Furthermore, patients with severe damage to the myocardium after myocardial infarction had increased PCT concentrations that were associated with an increased early (after 48 h) and 6-month mortality. 14 Remskar et al observed an association between PCT levels and poor outcome (severe heart failure, cardiogenic shock) after acute myocardial infarction in patients with PCT concentration >0.5 ng/ml during the time course of follow-up. 17 Resuscitation after cardiac arrest and/or concomitant bacterial infections increased PCT to remarkably higher levels.…”

Section: -24mentioning

confidence: 99%

Association of Serum Procalcitonin With Cardiovascular Prognosis in Coronary Artery Disease

Sinning

Schulz

et al. 2011

Circ J

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Background: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD). Methods and Results:A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information. Conclusions:PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome. (Circ J 2011; 75: 1184 - 1191

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“…In contrast, several studies have shown that PCT concentrations were in the normal range in patients with uncomplicated STEMI [15,16]. Many previous studies have confirmed that elevated PCT levels were associated with poor clinical outcomes in patients with acute coronary syndrome [17][18][19].…”

Section: Introductionmentioning

confidence: 84%

The association of serum procalcitonin level with the no-reflow phenomenon after a primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction

Murat

Kurtul

Çelik

et al. 2016

Coronary Artery Disease

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Procalcitonin: A Novel Cardiac Marker with Prognostic Value in Acute Coronary Syndrome

Cited by 34 publications

References 27 publications

Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension

Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension

Association of Serum Procalcitonin With Cardiovascular Prognosis in Coronary Artery Disease

The association of serum procalcitonin level with the no-reflow phenomenon after a primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction

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