Procalcitonin

Hamade, Bachar; Huang, Defeng

doi:10.1016/j.ccc.2019.08.003

Cited by 112 publications

(55 citation statements)

References 91 publications

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“…A reduction in serum prealbumin concentrations typically indicates the presence of acute inflammation and/or malnutrition, unlike other biomarkers such as CRP and procalcitonin which predominantly reflect the inflammatory burden (42)(43)(44). Its relatively short half-life makes it a suitable marker to assess and monitor rapid changes inflammatory burden and nutritional state.…”

Section: Discussionmentioning

confidence: 99%

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2021

Front. Med.

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Excessive inflammation and malnutrition are associated with coronavirus disease 2019 (COVID-19) severity and mortality. Combined biomarkers of malnutrition and inflammation, such as serum prealbumin, might be particularly attractive for early risk stratification. We conducted a systematic review and meta-analysis of studies reporting serum prealbumin in patients with COVID-19. We searched PubMed, Web of Science and Scopus, between January and November 2020, for studies reporting data on serum prealbumin, COVID-19 severity, defined as severe illness, prolonged viral load, receiving mechanical ventilation or admitted to intensive care unit (ICU), and mortality. Nineteen studies in 4,616 COVID-19 patients were included in the meta-analysis. Pooled results showed that serum prealbumin concentrations were significantly lower in patients with severe disease and non-survivors (standard mean difference, SMD, −0.92, 95% CI, −1.10 to −0.74, P < 0.001). Extreme heterogeneity was observed (I2 = 77.9%; P < 0.001). In sensitivity analysis, the effect size was not significantly affected when each study was in turn removed (range between −0.86 and −0.95). The Begg's (P = 0.06) and Egger's t-tests (P = 0.26) did not show publication bias. Pooled SMD values were significantly and negatively associated with age (t = −2.18, P = 0.045) and C-reactive protein (t = −3.85, P = 0.002). In our meta-analysis, lower serum prealbumin concentrations were significantly associated with COVID-19 severity and mortality. This combined marker of malnutrition and inflammation might assist with early risk stratification and management in this group.

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Section: Discussionmentioning

confidence: 99%

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2021

Front. Med.

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“…Another protein that can serve as an inflammatory marker is PCT, a peptide precursor of calcitonin that consists of 116 amino acids. Calcitonin is initially biosynthesised as PCT, which, under normal conditions, is found in low levels in the circulation [ 19 ]. PCT viral infection may be released under the action of proinflammatory mediators such as IL-6, TNF release or the like, which leads to elevated levels of peripheral blood [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe vs. common disease

Wang

et al. 2021

Epidemiol. Infect.

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To assess the relationship between the neutrophil-to-lymphocyte ratio (NLR) and related parameters to the severity of coronavirus disease 2019 (COVID-19) symptoms. Clinical data from 38 COVID-19 patients who were diagnosed, treated and discharged from the Qishan Hospital in Yantai over the period from January to February 2020 were analysed. NLR and procalcitonin (PCT) were determined in the first and fourth weeks after their admission, along with the clinical characteristics and laboratory test results of these patients. Based on results as obtained on the first and fourth weeks after admission, five indices consisting of NLR, white blood cells, neutrophils, lymphocytes (LY) and monocytes (MON) were selected to generate receiver operating characteristic curves, while optimal cutoff values, sensitivities and specificities were obtained according to the Yuden index. Statistically significant differences in neutrophils, LY and the NLR were present in the severe vs. moderate COVID-19 group from the first to the fourth week of their hospitalisation. The cut-off value of NLR for predicting the severity of COVID-19 was 4.425, with a sensitivity of 0.855 and a specificity of 0.979. A statistically significant positive correlation was present between PCT and NLR in the severe group as determined within the first week of admission. NLR can serve as a predictor of COVID-19 disease severity as patients' progress from the first to the fourth week of their hospitalisation. The statistically significant positive correlation between levels of NLR and PCT in severe patients indicated that increases in NLR were accompanied with gradual increases in PCT.

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“…The elevation of PCT indicates bacterial infection, while the elevation of CRP indicates inflammation in the body. 12 It could be observed from Table 2 that there were no significant differences in the proportions of patients with abnormal PCT and CRP among the three groups (P > .05). This indicated that PCT and CRP were lowly correlated with the disease severity of COVID-19.…”

Section: Comparison Of Blood Routine and Other Pneumonia-related Blmentioning

confidence: 81%

Detection and analysis of clinical features of patients with different types of coronavirus disease 2019

Zhao

Zhou

Pan

et al. 2020

Journal of Medical Virology

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Objective This study was designed to investigate the change of various indexes in patients with different types of coronavirus disease 2019 (COVID‐19). Methods 75 COVID‐19 patients were collected from the First Affiliated Hospital, Zhejiang University School of Medicine, and they were classified into moderate, severe and critically severe types according to the disease severity. The basic information, blood routine, pneumonia‐related blood indexes, immune‐related indexes along with liver, kidney and myocardial indexes in patients with different types were analyzed. Results The analysis of immune‐related indexes showed that the proportions of critically severe patients with abnormal IL‐2 and IL‐4 were higher than those of severe and moderate patients. In addition, the proportion of patients with abnormal total cholesterol increased as the severity of disease increased, and the proportion in critically severe patients was significantly higher than that in moderate patients. Conclusions The patients with a more severe COVID‐19 are older and more likely to have a history of hypertension. With the progression of COVID‐19, the abnormal proportion of total white blood cell, neutrophils, lymphocytes, IL‐2, IL‐4 and total cholesterol increased. The change of these indexes in patients with different COVID‐19 types could provide reference for the disease severity identification and diagnosis of COVID‐19. In addition, the change in the total cholesterol level suggested that COVID‐19 would induce some liver function damage in patients. This article is protected by copyright. All rights reserved.

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Procalcitonin

Cited by 112 publications

References 91 publications

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Serum Prealbumin Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis

Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe vs. common disease

Detection and analysis of clinical features of patients with different types of coronavirus disease 2019

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