Procaine Penicillin

Comparative Merits of Sodium and Procaine Penicillin

“…29, 1949 SODIUM AND PROCAINE PENICILLIN BRITIsH 959 MEDICAL JOURNAL in the majority of patients (Jones and Shooter, 1948); the second group received two intramuscular injections of 300.000 units of sodium p-nicillin in saline in the day. In the latter method penicillin was given when the patient was first seen, and subsequently between 9 and 10 o'clock in the morning and at 5 o'clock in the afternoon.…”

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

“…This paradox might be explained by differences in the sulphonamides used. Much of the available information on the serum levels obtained with procaine penicillin concerns either small doses no longer used in the treatment of gonorrhoea (Pulaski and Connell, 1949;Jones and Shooter, 1948;Boger, Crosley, Carfagno, and Bayne, 1952), or doses used for the treatment of syphilis for which lower serum levels were considered necessary (Guthe, Reynolds, Krag, and Wilcox, 1953). Data on serum levels obtained after administering various penicillin preparations are given in Tables XV to XXIV, those mainly concerned with doses relevant to the present-day treatment of gonorrhoea being presented in Tables XVII-XXIV.…”

Use of Procaine Penicillin in Children

“…The only paper that is concerned with children is that of Carson et al (1949). It will be seen that, in the larger adult series, 34 of 62 patients (Hewitt et al, 1948), 33 of 78 patients (Thomas et al, 1948), and 21 of 29 patients (Jones and Shooter, 1948) The preparation of procaine penicillin in arachis oil is viscid, and accurate measurement is difficult. Accordingly empirical dosage on an age basis was adopted.…”