Procainamide-induced systemic lupus erythematosus.

Sheldon, P.; Williams, W. Roger

doi:10.1136/ard.29.3.236

Cited by 20 publications

(3 citation statements)

References 23 publications

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“…Elevation of anti-IgG levels may be a reflection of a disorder of immune complexes. Similar values have been found (Torrigiani, Ansell, Chown, and Roitt, 1969), seronegative rheumatoid arthritis (Torrigiani and Roitt, 1967), and procainamideinduced systemic lupus erythematosus (Sheldon and Williams, 1970). Of the fifteen females, three remained seropositive, and six converted from seronegative to seropositive, one from seropositive to weakly positive, and five from seronegative to weakly positive.…”

Section: Antiglobulinssupporting

confidence: 78%

Palindromic rheumatism. Clinical and immunological studies.

Williams¹,

Sheldon²,

Torrigiani³

et al. 1971

Annals of the Rheumatic Diseases

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Section: Antiglobulinssupporting

confidence: 78%

Palindromic rheumatism. Clinical and immunological studies.

Williams¹,

Sheldon²,

Torrigiani³

et al. 1971

Annals of the Rheumatic Diseases

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“…Procainamide-treated patients are of special interest because they frequently develop a syndrome similar to idiopathic SLE (22)(23)(24)(25)(26). Anti-dDNA is often found (3,22), but its relationship to the clinical manifestations have not been established.…”

mentioning

confidence: 99%

Anti‐DNA antibody in procainmide‐induced lupus erythematosus. Determination using DNA fractionated by methylated albumin‐kieselguhr chromatography

Winfield

Davis

1974

Arthritis & Rheumatism

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Both putatively native(n) commercial calf thymus DNA and I4C labeled human KB DNA contained significant amounts of denatured DNA (dDNA) as determined by methylated albumin-kieselguhr chromatography. The proportion of dDNA in these preparations was sufficient to cause confusion regarding the antigenic specificity of anti-DNA antibody when unfractionated DNA was used in either the counterimmunoelectrophoresis or the Farr assays for anti-DNA antibody. Serum from patients with systemic lupus erythematosus contained both anti-nDNA and anti-dDNA antibodies. About 50 % of patients with symptomatic procainamide-induced lupus (PLE) exhibited anti-dDNA; none had anti-nDNA. Procainamide treated patients with a positive ANF who did not have symptomatic PLE had neither anti-dDNA nor anti-nDNA. Considerable data sumort the concept & Ithat native DNA (nDNA) and anti-nDNA antibody are of primary pathogenetic im-

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“…In addition to ANA, a spectrum of serologic and hematologic changes has been observed (1,2,4. [12][13][14][15][16][17][18]. The most common mechanism proposed to explain the development of autoantibodies in drug-induced LE is a drug-nucleoprotein interaction believed to enchance the autoimmunogenicity of nuclear components (2, [19][20][21][22].…”

mentioning

confidence: 99%

Effects of long‐term procainamide therapy on immunoglobulin synthesis

Ziff

1985

Arthritis & Rheumatism

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Procainamide is a potent inducer of autoantibodies. In order to evaluate the immunologic effects of this drug in vivo, 23 cardiac disease patients who had received procainamide for at least 6 months and an equal number of matched cardiac disease control subjects were studied, and percentage of circulating T cell subsets, concanavalin A-induced suppressor cell activity, and pokeweed mitogen-stimulated generation of immunoglobulin-secreting cells was quantitated. There was no significant difference between patient and control groups in the percentage of T cell subsets defined by OKT4 and OKT8 monoclonal antibodies or in concanavalin A-induced suppressor cell activity. The numbers of pokeweed mitogen-induced immunoglobulinsecreting cells were markedly decreased in the patient group, as measured by the protein A-augmented reverse hemolytic plaque assay (3,000 +-644, mean f SEM in patients versus 10,826 f 1,529, mean f SEM in control subjects, P < 0.005). Removal of the adherent cell fraction did not improve the hyporesponsiveness. When B and T cell fractions of 6 patients were mixed with

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Procainamide-induced systemic lupus erythematosus.

Cited by 20 publications

References 23 publications

Palindromic rheumatism. Clinical and immunological studies.

Palindromic rheumatism. Clinical and immunological studies.

Anti‐DNA antibody in procainmide‐induced lupus erythematosus. Determination using DNA fractionated by methylated albumin‐kieselguhr chromatography

Effects of long‐term procainamide therapy on immunoglobulin synthesis

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