Probucol neuroprotection against manganese-induced damage in adult Wistar rat brain slices
Sarah Camboim Del Rio Naiz,
Karina Giacomini Varela,
Diego de Carvalho
et al.
Abstract:Manganese (Mn) is an abundant element used for commercial purposes and is essential for the proper function of biological systems. Chronic exposure to high Mn concentrations causes Manganism, a Parkinson's-like neurological disorder. The pathophysiological mechanism of Manganism remains unknown; however, it involves mitochondrial dysfunction and oxidative stress. This study assessed the neuroprotective effect of probucol, a hypolipidemic agent with anti-inflammatory and antioxidant properties, on cell viabilit… Show more
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