Probucol markedly reduces HDL phospholipids and elevated preβ1-HDL without delayed conversion into α-migrating HDL: Putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling

Miida, Takashi; Seino, Utako; Miyazaki, Osamu; Hanyu, Osamu; Hirayama, Satoshi; Saito, Toshikazu; Ishikawa, Yuichi; Akamatsu, Suguru; Nakano, Toshimitsu; Nakajima, Katsuyuki; Okazaki, Mitsuyo; Okada, Masahiko

doi:10.1016/j.atherosclerosis.2007.12.031

Cited by 61 publications

(38 citation statements)

References 30 publications

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“…ELISA was used to determine the plasma contents of apoA-V (23, 33), apoC-II (34), apoC-III (34), apoE (34), and angptl3 (35). ApoA-I and apoB were analyzed with a commercially available assay (Wako Chemicals USA, Inc.) on a Cobas Mira autoanalyzer (Roche Diagnostics).…”

Section: Lipid and Lipoprotein Analysismentioning

confidence: 99%

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients*

Pullinger

Aouizerat

Movsesyan

et al. 2008

Journal of Lipid Research

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Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.185Gly.Cys (c.553G.T; rs2075291) polymorphism on plasma TG levels in subjects of Chinese ancestry living in the United States and in a group of non-Chinese Asian ancestry. The frequency of the less common cysteine allele was 4-fold higher (15.1% vs. 3.7%) in Chinese high-TG subjects compared with a low-TG group (Chi-square 5 20.2; P , 0.0001), corresponding with a 4.45 times higher risk of hypertriglyceridemia (95% confidence interval, 2.18-9.07; P , 0.001). These results were replicated in the non-Chinese Asians. Heterozygosity was associated, in the high-TG group, with a doubling of TG (P , 0.001), mainly VLDL TG (P 5 0.014). All eleven TT homozygotes had severe hypertriglyceridemia, with mean TG of 2,292 6 447 mg/dl. Compared with controls, carriers of the T allele had lower postheparin lipoprotein lipase activity but not hepatic lipase activity. In Asian populations, this common polymorphism can lead to profound adverse effects on lipoprotein profiles, with homozygosity accounting for a significant number of cases of severe hypertriglyceridemia. This specific apoA-V variant has a pronounced effect on TG metabolism, the mechanism of which remains to be elucidated.-Pullinger, C.

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Section: Lipid and Lipoprotein Analysismentioning

confidence: 99%

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients*

Pullinger

Aouizerat

Movsesyan

et al. 2008

Journal of Lipid Research

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“…The highest activity has been shown by the combination of "Enoant" and ethanol that corresponds to the ratio of components in dry red wines, as well as the absence of significant difference in the protective effects of red and white wines, in spite of the difference in the polyphenol content [55]. Based on these results, in the second series of our experiments we decided to investigate "Cabernet" and "Rkatsiteli" wine effects on the development of stress-reaction proatherogenic consequences under the action of the emotional-painful stress in different periods of introduction.…”

Section: 031mentioning

confidence: 99%

Antioxidant Complexes and Lipoprotein Metabolism – Experience of Grape Extracts Application Under Metabolic Syndrome and Neurogenic Stress

Zagayko¹,

Kravchenko²,

Krasilnikova³

2012

Lipoproteins - Role in Health and Diseases

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“…Activation of CETP increases transfer of cholesterol esters from HDL to triglyceride-rich lipoprotein particles in exchange for triglyceride, thereby reducing the circulating HDL cholesterol concentration. Probucol-activated CETP increases preβ1-HDL (lipid-poor apoA1), which participates in the cholesterol efflux, and decreases HDL particle size 27) . A prethose without plaque regression.…”

Section: Clinical Outcomes and Adverse Eventsmentioning

confidence: 99%

Effects of Combination Therapy with Cilostazol and Probucol versus Monotherapy with Cilostazol on Coronary Plaque, Lipid and Biomarkers: SECURE Study, a Double-Blind Randomized Controlled Clinical Trial

Choi

Kang

et al. 2014

JAT

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Aim:The study aim is to investigate synergistic effects of cilostazol and probucol combination therapy on coronary plaque volume and composition. Methods: A total of 119 patients undergoing coronary stenting were treated with probucol and cilostazol combination therapy (group Ⅰ) or with cilostazol monotherapy (group Ⅱ) in a double-blind, randomized multicenter trial, and evaluated by virtual histology intravascular ultrasound (VH-IVUS) at baseline and 9-month follow-up for changes in coronary plaque volume and composition at an index intermediate lesion with luminal narrowing ≥ 30% and ＜70% and for neointimal hyperplasia at the stented segment. In all patients simvastatin 20 mg was started with enrollment. Results: Qualifying VH-IVUS data from 91 patients were included in the final analysis. There were no significant differences between group Ⅰ and Ⅱ with respect to the primary endpoint, nominal change in normalized total atheroma volume (

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Probucol markedly reduces HDL phospholipids and elevated preβ1-HDL without delayed conversion into α-migrating HDL: Putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling

Cited by 61 publications

References 30 publications

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients*

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients*

Antioxidant Complexes and Lipoprotein Metabolism – Experience of Grape Extracts Application Under Metabolic Syndrome and Neurogenic Stress

Effects of Combination Therapy with Cilostazol and Probucol versus Monotherapy with Cilostazol on Coronary Plaque, Lipid and Biomarkers: SECURE Study, a Double-Blind Randomized Controlled Clinical Trial

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