Problems of anticoagulant therapy in cerebrovascular disease

Idiopathic Intracranial Hypertension in a Pediatric Population: A Retrospective Analysis of the Initial Imaging Evaluation

“…14 Other authors have recommended supportive care only for these patients. 15,16 This is the first article to evaluate the use of magnetic resonance venography in the clinical evaluation of suspected idiopathic intracranial hypertension in pediatric patients. Within this retrospective study there are a small number of patients and the intrinsic referral bias of a tertiary care center.…”

Cerebral Vascular Insufficiency

“…In the series reported by Groch et al (1959) 20% had com plications. Many of these were minor disorders and some bleeding phenomena arose from unrelated pathological processes such as carcinoma of gut, prostatic hypertrophy or ulcerative colitis.…”

“…Groch et al (1959) have shown how compli cations increase with age (Table II). There is no definite agreement about the length of time a patient having transient ischaemic attacks should be on anticoagu lants.…”

“…There is no definite agreement about the length of time a patient having transient ischaemic attacks should be on anticoagu lants. Fisher (1961) and Millikan et al (1958) Groch et al (1959) have outlined the problems in maintaining a group of patients for periods of up to two years and point out how frequently the prothrombin times are above or below therapeutic range, so that regular dosage with anticoagulants is not necessarily synonym ous with continuous protection from thrombosis. With any therapy that carries definite risks, it is obvious that the longer treatment is continued, the greater the chance of complications.…”

Cerebral Circulatory Insufficiency

“…In considering the beneficial effects of anticoagulants in relation to pathogenesis of cerebrovascular disease, the reverse phenomenon should be recalled which may be seen on withdrawing such therapy. So-called "rebound phenomena", new thromboembolic lesions occurring in the first weeks after discontinuing anticoagulant therapy, have been described by Groch et al (1959) and by Marquardsen & Olivarius (1959). This is in agreement with the fact that clotting phenomena occur with increasing frequency in the period up to six weeks after stopping anticoagulant therapy (Carter et al 1958).…”