Problems in gynaecologic oncology in girls and young women—an outline of selected issues

Plagens-Rotman, Katarzyna; Połocka-Molińska, Maria; Merks, Piotr; Gwoździcka-Piotrowska, Matylda; Kędzia, Witold; Jarząbek-Bielecka, Grażyna

doi:10.31083/j.ceog4804127

Cited by 4 publications

(3 citation statements)

References 23 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cervical cancer (CC) is the fourth most common cancer in women worldwide, following breast, colorectal, and lung cancers ( 1 ), and is one of the most common gynecological malignancies ( 2 , 3 ). Approximately 570,000 new cases of CC and 311,000 deaths occurred in 2018, and China is among the countries with the greatest burden of CC ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

An interpretable clinical ultrasound-radiomics combined model for diagnosis of stage I cervical cancer

Yang,

Gao,

Sun

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThe purpose of this retrospective study was to establish a combined model based on ultrasound (US)-radiomics and clinical factors to predict patients with stage I cervical cancer (CC) before surgery.Materials and methodsA total of 209 CC patients who had cervical lesions found by transvaginal sonography (TVS) from the First Affiliated Hospital of Anhui Medical University were retrospectively reviewed, patients were divided into the training set (n = 146) and internal validation set (n = 63), and 52 CC patients from Anhui Provincial Maternity and Child Health Hospital and Nanchong Central Hospital were taken as the external validation set. The clinical independent predictors were selected by univariate and multivariate logistic regression analyses. US-radiomics features were extracted from US images. After selecting the most significant features by univariate analysis, Spearman’s correlation analysis, and the least absolute shrinkage and selection operator (LASSO) algorithm, six machine learning (ML) algorithms were used to build the radiomics model. Next, the ability of the clinical, US-radiomics, and clinical US-radiomics combined model was compared to diagnose stage I CC. Finally, the Shapley additive explanations (SHAP) method was used to explain the contribution of each feature.ResultsLong diameter of the cervical lesion (L) and squamous cell carcinoma-associated antigen (SCCa) were independent clinical predictors of stage I CC. The eXtreme Gradient Boosting (Xgboost) model performed the best among the six ML radiomics models, with area under the curve (AUC) values in the training, internal validation, and external validation sets being 0.778, 0.751, and 0.751, respectively. In the final three models, the combined model based on clinical features and rad-score showed good discriminative power, with AUC values in the training, internal validation, and external validation sets being 0.837, 0.828, and 0.839, respectively. The decision curve analysis validated the clinical utility of the combined nomogram. The SHAP algorithm illustrates the contribution of each feature in the combined model.ConclusionWe established an interpretable combined model to predict stage I CC. This non-invasive prediction method may be used for the preoperative identification of patients with stage I CC.

show abstract

Section: Introductionmentioning

confidence: 99%

An interpretable clinical ultrasound-radiomics combined model for diagnosis of stage I cervical cancer

Yang,

Gao,

Sun

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Cervical cancer is among the most common gynecological malignancies in women ( 1 – 3 ). Approximately 570 000 new cases of cervical cancer and 311 000 deaths occurred in 2018, and China is among the countries with the greatest cervical cancer burden ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

The burden of cervical cancer in China

et al. 2022

View full text Add to dashboard Cite

ObjectiveTrends in the incidence, disability-adjusted life-years (DALYs), and mortality rate of cervical cancer remain unknown.MethodsThe average annual percent changes (AAPCs) and relative risks (RR) in the incidence, DALYs, and mortality rate were determined using a joinpoint regression analysis; the net age, period, and cohort effects on above rates were evaluated.ResultsA significant increase in age-standardized incidence (AAPC, 0.9%; 95CI: 0.8, 1.1) but significant decreases in age-standardized DALYs (AAPC, -0.4%; 95%CI: -0.60, -0.20) and the mortality rate (AAPC, -0.4%; 95CI: -0.6, –0.3) were observed. As for age-specific rates, the incidence was higher in younger age groups, and the DALYs and mortality rate were lower in older age groups. The effects of age included a slight but significant increase in the RR with advancing age from 35 to 94 years; the period effect included a significant increase in the incidence over the 2005–2019 periods; and the cohort effect included a substantial increase in the incidence from earlier to later birth cohorts.ConclusionsThe incidence of cervical cancer increased from 1990 to 2019, particularly in younger age groups, and the DALYs and mortality rate decreased in the older age groups. Furthermore, the incidence increased with age, period, and cohort.

show abstract

“…Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence. For sexual health to be attained and maintained, the sexual rights of all persons must be respected, protected and fulfilled" [2][3], and the condition for good sexual health is having safe and responsible sexual behaviours.…”

Section: Introductionmentioning

confidence: 99%

STD-Related sexual and gynaecological issues, including lesions of the genital organs and oral cavity

Plagens-Rotman,

Merks,

Opydo-Szymaczek

et al. 2022

Pielegniarstwo XXI Wieku / Nursing in the 21st Century

Self Cite

View full text Add to dashboard Cite

Human sexual life takes place at the biological, mental and social levels. Sexually transmitted diseases are an important issue associated particularly with the biological sphere, and have been on the rise in recent years. The wide spectrum of symptoms and consequences depends on aetiology and advancement, accompanying symptoms and/or their absence, as well as local, generalised and multiorgan lesions. They can also be present in the oral cavity. The prevention and treatment of these diseases is a special sphere of healthcare. In the context of sexual health, healthcare can be understood as integration of the biological, emotional, intellectual and social aspects of sexual life, being also important for the positive development of personality, communication and love.

show abstract

Problems in gynaecologic oncology in girls and young women—an outline of selected issues

Cited by 4 publications

References 23 publications

An interpretable clinical ultrasound-radiomics combined model for diagnosis of stage I cervical cancer

An interpretable clinical ultrasound-radiomics combined model for diagnosis of stage I cervical cancer

The burden of cervical cancer in China

STD-Related sexual and gynaecological issues, including lesions of the genital organs and oral cavity

Contact Info

Product

Resources

About