The growth of the country's innovative potential is impossible without the innovative development of its territories. It is the regional innovative development that determines the innovative path of the state, ensures its competitiveness and helps to strengthen its position in the world market. At the same time, industrial enterprises play a decisive role in the activities of the region, which not only affect the socio-economic indicators of the region, but also ensure its innovative development. Industrial enterprises produce innovative products, promote the introduction of innovations, create high-tech jobs, which affects the innovative potential of the region and its innovative activities. Thanks to industrial enterprises, a favorable innovation climate is being formed in the region. At the same time, in modern conditions, the development of industrial enterprises can only be ensured through digital transformations. Digitalization is becoming an integral part of the business processes of industrial structures and determines their innovative focus. It is the digital transformation of industrial enterprises that should form the basis of regional innovative development. The article is devoted to the study of the role of digital transformation of industrial enterprises in the innovative development of the region. In the study, based on the identified approaches to the definition of the concept of "digital transformation", the author's interpretation of "digital transformation of industrial enterprises" is proposed. Based on the analysis of the indices of innovative development of regions and the level of digitalization of industrial enterprises, the influence of the latter on regional innovative development is determined. The methodological apparatus used in the study, which includes methods of economic analysis, statistical generalizations and groupings, graphic presentation of the material, made it possible to identify the relationship between the digital transformation of industrial enterprises and indicators of the innovative development of the region, on the basis of which the authors substantiated the need to develop a strategy for creating conditions for digital transformation industrial enterprises of the region, based on indicators of regional innovative development and taking into account the specifics of its production sphere. The conclusions obtained in the course of the study have a scientific and practical orientation and can be used in the formation of digital transformation strategies by regions.