Problems and Immediate Outcome of Infants of Diabetic Mothers

Mahmood, Chowdhury B; Kayes, Mohammad Imrul

doi:10.3329/jbcps.v26i2.4183

Cited by 10 publications

(21 citation statements)

References 10 publications

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“…In the present study, incidence of hypoglycemia was significantly higher in IGDMs. This observation was in contrast to the results obtained in studies done earlier [11,13] where the incidence of hypoglycemia was higher in IPGDMs. In the present study, most of the mothers with PGDM had good glycemic control which probably prevented fetal hyperinsulinism and significant hypoglycemia.…”

Section: Discussioncontrasting

confidence: 99%

“…Similar observation was seen in the studies conducted by Mohsin et al [12] and Nili Firouzeh et al [13]. In the present study, incidence of congenital malformations was 17.40% and was slightly higher than those reported previously [9][10][11]14]. This was probably because…”

Section: Discussionsupporting

confidence: 92%

“…Similar observations were reported in the studies done previously [11][12][13]. Due to maternal hyperglycemia, there occurs fetal hyperglycemia as a result of which there is fetal hyperinsulinism.…”

Section: Discussionsupporting

confidence: 91%

“…Most of these neonates were delivered at term and were appropriate for gestational age. Similar observation was seen in the study conducted by Mahmood CB et al [11]. However, in the study conducted by Ranade et al [10] the proportion of preterm deliveries was higher and was probably because they included all diabetic mothers with coexisting medical complications like PIH, chronic heart and renal disease.…”

Section: Discussionsupporting

confidence: 82%

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A study of clinical, metabolic and hematological profile in infants of diabetic mothers

Gopal

2014

IJPBR

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Background:Diabetes has long been associated with maternal and perinatal mobidity and mortality. Infants of diabetic mothers (IDMs) have higher risks for serious problems during pregnancy, delivery and early neonatal period. Abnormal fetal metabolism during pregnancy which is complicated by maternal diabetes mellitus results in multiple neonatal sequelae. Objective: To study the clinical, metabolic and hematological profile in infants of diabetic mothers and to compare the neonatal outcome in gestational and pregestational (overt) diabetic mothers. Methods: 69 neonates born to diabetic mothers were enrolled in the study. Gestational age, birth weight, relevant perinatal history and examination findings were recorded. Blood samples were collected to perform relevant biochemical tests and managed as per unit protocol. Echocardiography and ultrasound abdomen was done routinely in all neonates. Results: Of the 69 neonates, 71.01% (49/69) were born to mothers with gestational diabetes mellitus (GDM), while the remaining 28.99% (20/69) were born to mothers with pregestational (overt) diabetes mellitus (PGDM). 53.63% (37/69) of mothers had poor glycemic control. Most of the neonates (73.91% - 51/69) were delivered by cesarean section. 88.40% (61/69) of the babies were born at term. Majority of them (85.50% - 59/69) were appropriate for gestational age with mean birth weight of 3.06±0.82kgs. Hypoglycemia was the most common metabolic abnormality seen in 73.91% (51/69) of neonates. Polycythemia was seen in 60.80% (42/69) of neonates. Congenital malformations were seen in 17.40% (12/69) of neonates, of which most of them had congenital heart disease. 11.60% (8/69) of the babies had suffered birth injuries. 5.80% (4/69) of neonates died in the early neonatal period. Occurrence of hypoglycemia, polycythemia, hyperbilirubinemia, congenital anomalies and birth injuries were significantly higher in infants born to mothers with GDM, whereas hypocalcemia and hypomagnesemia were significantly higher in infants of mothers with PGDM. Conclusions: Among the pregnancies complicated by diabetes, GDM continues to have a major contribution. Hypoglycemia and polycythemia remain the most common biochemical and hematological abnormality respectively. Congenital heart disease forms a major proportion of the congenital anomalies seen in IDMs. Mortality rate is higher in infants born to mothers with GDM.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

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A study of clinical, metabolic and hematological profile in infants of diabetic mothers

Gopal

2014

IJPBR

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“…This was different from the studies done by Mahmood CB et al and Firouzeh N et al, where the incidence of hypoglycemia was statistically significant in overt DM. 10,13 This difference may be attributed to good glycemic control in overt DM and poor glycemic control in GDM mothers as, in most of the situations, the diabetes was detected during delivery and in few instances, diabetes was diagnosed retrospectively after the delivery in the present study.…”

Section: Discussionmentioning

confidence: 60%

Morbidity and mortality of infant of diabetic mothers

Aziz¹,

Annamalai²,

Ahmed³

2018

Int J Contemp Pediatr

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Background: Diabetes mellitus is a chronic metabolic disorder due to either insulin deficiency (relative or absolute) or due to peripheral tissue resistance to the action of insulin. Women are classified into those who were known to have diabetes before pregnancy as Pregestational or overt, and those diagnosed during pregnancy as Gestational. The study was conducted in infants born to diabetic mothers focusing on the morbidity and mortality of the neonates.Methods: This is a cross-sectional study which was carried out in the Neonatal Unit, Department of Pediatrics, Sree Balaji Medical College and Hospital from July 2014 to July 2015. The study population comprises of 65 Neonates of mothers diagnosed to have gestational diabetes mellitus or overt diabetes mellitus. Screening and appropriate investigations was done for the neonates.Results: 65 neonates of Infants of Diabetic Mother were studied, 48(73.85%) were born to mothers with Gestational Diabetes Mellitus and 17 (26.15%) were born to mothers with Overt Diabetes Mellitus. The most common morbidity in neonate born to GDM mothers compared to overt DM mothers was hyperbilirubinemia (52.08%), hypoglycaemia (50%), polycythemia (43.75%). Ventricular septal defect (17.65%) was the most common cardiac finding in overt DM mothers. P values (0.05%) were significant for hyperbilirubinemia, hypoglycaemia and polycythemia when compared with infants of GDM mothers and overt DM mothers. There was no mortality in present study.Conclusions: The occurrence of morbidities and mortality were more significant in the infants of GDM mothers when compared to overt DM mothers who had good glycemic control before and during the pregnancy.

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