Problèmes posés par la détection du dopage à la testostérone

Lacoste, Alain; Gautier, D.; Guezennec, C. Y.; Huet, F.; Joussellin, E

doi:10.1016/s0765-1597(05)80027-9

Cited by 2 publications

(1 citation statement)

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“…Because the T/E value is statistically determined, it cannot be excluded that a T/E ratio above 6 may be observed without exogenous testosterone administration. For example, after a competition, a T/E ratio above 6 was recently measured for an athlete, without any sign or biological proof of exogenous testosterone administration (16). The risk of false positive subjects has been estimated to be 15 out of 10,000 by Dehenin and Scholler (5) and was attributed principally to a congenital defect in steroid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Effect of Competition Stress on Tests Used to Assess Testosterone Administration in Athletes

Guezenned

Lafarge²,

Bricout

et al. 1995

Int J Sports Med

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The drug test for exogenous administration of testosterone is based on the testosteronelepitestosterone ratio (TIE) in urine. Physiological and psychological stresses may alter plasma testosterone concentrations. The question is to know how much the psychological conditions of competition can modify the TIE ratio. In order to study this issue, 20 athletes practising modern pentathlon participated in a study designed to determine the effects of a pistol shooting trial on their hormonal response. Pistol shooting induces a high psychological stress without increasing energy expenditure. Venous blood samples were drawn before and after the trial according to the usual drug testing procedure. Athletes were separated into two groups: a group of young athletes ( n = 10; mean age 19 f 0.3 years) and another group of aged subjects (n = 10; mean age 45f 1.5 years). The rise in plasma testosterone concentrations reached 75 % in older subjects versus 55 % in younger ones. The plasma luteinizing hormone (LH) concentrations were not influenced by the trial. After shooting trial the elevation in cortisol concentrations was greater for oldersubjects than for younger ones (273 f 30 ng . rnl-' vs 173 f 7 ng . mt-'). The catecholamine response was identical in both groups. The urinaryT/E ratio remained unchanged after the shooting trial and always remained lowerthan the International Olympic Committee limit of 6 . These results indicate that the psychological stress associated with competition increases the production of steroid hormones (testosterone, cortisol). and that this phenornenon is more pronounced in older athletes. These hormonal changes do not influence the urinary excretion of steroid metabolites used as criterion for drug testing. On

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Section: Introductionmentioning

confidence: 99%