Problemas clínicos en Micología Médica: problema n° 36

Negroni, Ricardo; Maiolo, Elena; Arechavala, Alicia; Duré, Roberto; Sacheri, Cristian; Orduña, Tomás

doi:10.1016/s1130-1406(08)70062-7

Cited by 1 publication

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Argentina there is no data regarding either incidence or prevalence of sporotrichosis, only few unique clinical cases have been reported, [16][17][18][19] the circulating species of Sporothrix is still unknown, and the in vitro susceptibility profile of species has not been previously studied.…”

Section: Discussionmentioning

confidence: 99%

“…15 Despite the clinical importance and the confirmed circulation of S. schenckii sensu lato in the region, there is no data in Argentina regarding either incidence or prevalence of sporotrichosis, the circulating species of Sporothrix is still unknown, only few unique clinical cases have been reported, and the in vitro susceptibility profile of species has not been previously studied. [16][17][18][19] Therefore, the aims of this study were: a-To identify using molecular methods, 23 strains of S. schenckii sensu lato deposited in a Culture Collection that were previously identified by phenotypical procedures as S. schenckii. b-To determine the in vitro susceptibility profile of strains against antifungal drugs.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Molecular identification and susceptibility profile of Sporothrix schenckii sensu lato isolated in Argentina

Córdoba

Isla

Szusz

et al. 2018

Mycoses

View full text Add to dashboard Cite

We studied 23 clinical and environmental strains of Sporothrix schenckii sensu lato collected from 1984 to 2017 in Argentina. The molecular identification (partial sequencing of a fragment of the calmodulin gene) of the strains was performed. For the yeast and mycelial phases, the in vitro susceptibility testing by a microdilution reference method was determined against eight antifungal drugs. Strains studied were identified as S. schenckii sensu stricto 13 (56.5%), S. brasiliensis 8 (34.7%) and S. globosa 2 (8.7%). The most active antifungal drugs tested for the yeast and mycelial phases expressed as geometric mean (GM) value of the minimal inhibitory concentration (MIC) (μg mL ) were terbinafine (0.07 and 0.24), posaconazole (0.13 and 0.58), itraconazole (0.38 and 1.10) and ketoconazole (0.22 and 0.89), while fluconazole (110.10 and 131.92) and flucytosine (2.96 and 79.03) were the less active. For voriconazole and amphotericin B the GM-MIC values were acceptably low for the yeast phase (0.39 and 0.72 μg mL ), while the mycelial phase showed values ≥2-fold higher (8.76 and 1.88 μg mL ), P < .05. Here, we described S. schenckii sensu stricto, S. brasiliensis and S. globosa, these species were isolated from humans, animals and soil and are circulating in Argentina since at least 1984.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%