Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline

Qaisar, Rizwan; Burki, Ayousha; Karim, Asima; Iqbal, M. Shahid; Ahmad, Firdos

doi:10.1007/s00223-024-01211-6

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Notably, age-associated muscle loss has been linked to increased gut permeability. A recent study reported that a 16-week probiotic intervention repaired intestinal barrier function and improved quality of life measures in older adults suffering muscle decline [17]. Thus, manipulation of the microbiota composition in older population is a promising potential strategy to prevent or reduce ageassociated disease and disability, especially when related to low-grade inflammation.…”

Section: Introductionmentioning

confidence: 99%

Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Lazou-Ahrén,

Björklund,

Molin

et al. 2024

Probiotics & Antimicro. Prot.

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The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older persons. This study explored the anti-inflammatory effects of Lactiplantibacillus plantarum HEAL9 (LpHEAL9), alone or combined with berries, on older volunteers with chronic low-grade inflammation (LGI). It was a randomized, double-blind, placebo-controlled trial, with a total of 66 volunteers (> 70 years old), randomly assigned, and equally distributed, to placebo, LpHEAL9 or LpHEAL9 + Berries group. After a 2-week run-in period, participants underwent a 4-week dietary intervention. Intake of LpHEAL9 showed a trend towards reduction in serum CRP but without reaching statistical significance. However, LpHEAL9 significantly decreased fecal calprotectin levels compared to placebo. LpHEAL9+Berries did not show any effect on inflammation. Both probiotic groups showed a trend in improving cognitive function albeit not reaching statistical significance. Our findings suggest that the probiotic strain L. plantarum HEAL9 has a modest impact on LGI in a healthy older population (ClinicalTrials.gov ID: NCT02342496).

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Section: Introductionmentioning

confidence: 99%