Probiotics Supplementation Improves Quality of Life, Clinical Symptoms, and Inflammatory Status in Patients With Psoriasis

The Role of Probiotic in Psoriasis Treatment: A Meta-Analysis of Randomized Controlled Clinical Trials

“…For 12 weeks, Navarro et al ( 2019) found that probiotics containing a mixture of three bacterial strains (Bi dobacterium longum, Bi dobacterium lactis, and Lactobacillus rhamnosus) had a higher proportion of PASI 75 than placebo group [12]. The same thing happened in a study by Moludi with probiotics containing a mixture of four bacterial strains (Lactobacillus acidophilus, Bi dobacterium bi dum, Bi dobacterium lactis, and Bi dobacterium langue) for 8 weeks [9,13]. The meta-analysis of the studies that evaluated PASI 75 revealed a statistically signi cant value, indicating that the administration of this oral probiotic has a positive effect on patient clinical improvement.…”

“…IL-6 levels were also reduced in the probiotic group by 4.04 mg/L (P < 0.05) and by 1.5 mg/L in the placebo group (P = 0.093) [13]. Moludi et al (2022) found a decrease in CRP levels of 1.67 mg/L (P < 0.05) in the probiotic group and 0.70 mg/L (P = 0.111) in the placebo group [9]. Based on the ndings of this meta-analysis, oral probiotics were found to be signi cantly more effective than placebo in lowering levels of in ammatory markers (particularly IL-6 and CRP).…”

“…PASI is commonly displayed as a percentage response rate, such as PASI 50, PASI 75, PASI 90, and PASI 100. PASI 75 is regarded as a psoriasis cure criterion [9].…”

“…There are seven scales ranging from 0 to 6 for the affected area. Each score represents a percentage of the affected area in each body region (0% to 100%) [9,10].…”

“…Lactobacillus Plantarum, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus paracasei, and Bi dobacterium animals have all been studied for this disease and have shown superiority in improving clinical conditions and pro-in ammatory cytokines. [8] Although the number of studies is small, several studies have shown an improved outcome in psoriasis patients receiving oral probiotic therapy [9]. A meta-analysis is required to establish the highest level of validity for existing studies.…”