Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort

Kuitunen, Mikael; Kukkonen, Kaarina; Juntunen‐Backman, Kaisu; Korpela, Riitta; Poussa, Tuija; Tuure, Tuula; Haahtela, Tari; Savilahti, Erkki

doi:10.1016/j.jaci.2008.11.019

Cited by 353 publications

(310 citation statements)

References 30 publications

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“…Likewise, the composition of the initial microbiota may have implications for nutritional and immune functions associated with the developing microbiota. For example, recent studies suggest that Cesarean-delivered babies may be more susceptible to allergies and asthma (31,32), and the administration of probiotics (including lactobacilli) from birth until age 6 mo reduced the incidence of allergy at age 5 y in C-section but not vaginally delivered children (33). Breastfeeding has been suggested to enrich vaginally acquired lactic acid-producing bacteria in the baby's intestine (34), although it is not clear that the predominant lactobacilli in the baby's intestine are the same as those acquired at birth from the mother's vagina (35).…”

Section: Resultsmentioning

confidence: 99%

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Domínguez-Bello

Costello²,

Contreras

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

3,790

104

3,254

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Upon delivery, the neonate is exposed for the first time to a wide array of microbes from a variety of sources, including maternal bacteria. Although prior studies have suggested that delivery mode shapes the microbiota's establishment and, subsequently, its role in child health, most researchers have focused on specific bacterial taxa or on a single body habitat, the gut. Thus, the initiation stage of human microbiome development remains obscure. The goal of the present study was to obtain a community-wide perspective on the influence of delivery mode and body habitat on the neonate's first microbiota. We used multiplexed 16S rRNA gene pyrosequencing to characterize bacterial communities from mothers and their newborn babies, four born vaginally and six born via Cesarean section. Mothers’ skin, oral mucosa, and vagina were sampled 1 h before delivery, and neonates’ skin, oral mucosa, and nasopharyngeal aspirate were sampled <5 min, and meconium <24 h, after delivery. We found that in direct contrast to the highly differentiated communities of their mothers, neonates harbored bacterial communities that were undifferentiated across multiple body habitats, regardless of delivery mode. Our results also show that vaginally delivered infants acquired bacterial communities resembling their own mother's vaginal microbiota, dominated by Lactobacillus , Prevotella, or Sneathia spp., and C-section infants harbored bacterial communities similar to those found on the skin surface, dominated by Staphylococcus , Corynebacterium , and Propionibacterium spp. These findings establish an important baseline for studies tracking the human microbiome's successional development in different body habitats following different delivery modes, and their associated effects on infant health.

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Section: Resultsmentioning

confidence: 99%

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Domínguez-Bello

Costello²,

Contreras

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

3,790

104

3,254

View full text Add to dashboard Cite

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“…Using non-conventional probiotics such as butyrate and proprionate producers, immunomodulatory strains of West 15 bacteroides 8,30 or clostridia 81 might also induce stronger effects. Another area to explore is that of probiotic treatment to CS-delivered infants, as data suggest that they might benefit the most 82 .…”

Section: Probioticsmentioning

confidence: 99%

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

West

Renz²,

Jenmalm

et al. 2015

Journal of Allergy and Clinical Immunology

218

165

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Rapid environmental transition and modern lifestyles are likely driving changes in the biodiversity of the human gut microbiota. With clear effects on physiologic, immunologic, and metabolic processes in human health, aberrations in the gut microbiome and intestinal homeostasis have the capacity for multisystem effects. Changes in microbial composition are implicated in the increasing propensity for a broad range of inflammatory diseases, such as allergic disease, asthma, inflammatory bowel disease (IBD), obesity, and associated noncommunicable diseases (NCDs). There are also suggestive implications for neurodevelopment and mental health. These diverse multisystem influences have sparked interest in strategies that might favorably modulate the gut microbiota to reduce the risk of many NCDs. For example, specific prebiotics promote favorable intestinal colonization, and their fermented products have anti-inflammatory properties. Specific probiotics also have immunomodulatory and metabolic effects. However, when evaluated in clinical trials, the effects are variable, preliminary, or limited in magnitude. Fecal microbiota transplantation is another emerging therapy that regulates inflammation in experimental models. In human subjects it has been successfully used in cases of Clostridium difficile infection and IBD, although controlled trials are lacking for IBD. Here we discuss relationships between gut colonization and inflammatory NCDs and gut microbiota modulation strategies for their treatment and prevention

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“…The microbiota structure can also be altered by an exposure to probiotics, when breastfeeding is not possible (66); additionally, such an effect may also be related to a prolonged reduction of allergies in CS-delivered children (67). Maternal and newborn treatments are another determinant of variability.…”

Section: Mother-child Symbiosismentioning

confidence: 99%

The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood

et al. 2014

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Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort

Cited by 353 publications

References 30 publications

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood

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