Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome

Simon, Elemér; Călinoiu, Lavinia Florina; Mitrea, Laura; Vodnar, Dan Cristian

doi:10.3390/nu13062112

Cited by 104 publications

(92 citation statements)

References 201 publications

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“…Furthermore, prebiotics and probiotics could be combined into "synbiotics" [23], so synergetic effects could be obtained, as the probiotic strain might be stimulated to grow by fermenting the prebiotic [6,24]. As of January 2022, there were 277 registered clinical trials (https://clinicaltrials.gov/ct2/results?term=prebiotics&Search=Apply&recrs= e&age_v=&gndr=&type=&rslt=, accessed on 6 January 2022) worldwide, the majority in Europe, which evaluated the effect of prebiotics (alone or in combination with probiotics) on body weight and obesity metabolic syndrome, type 2 diabetes mellitus, gastrointestinal disorders (diarrhea, constipation, enterocolitis), irritable bowel syndrome and inflammatory bowel disease, and cardiovascular diseases but also on anxiety disorders, arthritis, or allergies [25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers

Precup

Pocol

Teleky

et al. 2022

IJERPH

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The consumer awareness towards healthier diets and the impact of nutrition on health has triggered an increase in the production and commercialization of foods with health claims. The scientific literature classifies these food products as functional foods, with a role in promoting health and preventing diseases, and they had a market share of almost 200 million EUR in 2019. Prebiotics are considered functional foods, referring to substrates that are selectively utilized by host microorganisms conferring a health benefit, as defined by the International Scientific Association for Probiotics and Prebiotics. Several health benefits are associated with the consumption of prebiotics; however, specific requirements must demonstrate the causality between the specific ingredient and the claimed effect. Health claims associated with food products are assessed in the European Union and need to be supported by rigorous scientific evidence before being authorized and permitted on the market. Consumers’ perception of this topic is influenced by the various stakeholders involved. The current work aimed to study the consumers’ perception and interest and to assess the knowledge on the prebiotic concept in Romania. The consumer interest level was quantified by using the web-based data tool Google Trends, and a questionnaire-based investigation was designed. The collected data were analyzed with the help of the SPSS program, and crosstabulation was used to identify the influence of socio-demographic characteristics on diet choice and awareness of prebiotics. A total of 303 persons answered the online applied questionnaire, grouped as young consumers (15–24 years old) and adults (25–64 years old). Even if most responders were familiar with the term of prebiotics (74% of total responders), some results were contradictory regarding their knowledge. The work emphasized the need to carry out educational campaigns and inform consumers on the relationship between certain food ingredients and health outcomes in a clear way and based on a rigorous assessment of the scientific evidence.

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Section: Introductionmentioning

confidence: 99%

Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers

Precup

Pocol

Teleky

et al. 2022

IJERPH

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“…In addition, a beneficial anti-inflammatory effect has also been observed in certain pathological situations [ 78 ]. The mechanisms involved in these beneficial effects are currently the subject of numerous studies [ 84 ]. In addition, the neutrophil/lymphocyte ratio is a marker that reflects the state of systemic inflammation or oxidative stress [ 85 ].…”

Section: Resultsmentioning

confidence: 99%

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Kadja

Dib

Lakhdara

et al. 2021

Biology

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This study aimed to investigate the effects of three strains of probiotics, these being Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745, on the body weight, animal performances and blood parameters of rabbits (male and female) of the ITELV2006 strain. The supplementation of the feed of the rabbits with the three probiotic strains allowed observing positive effects on most of the biochemical and haematological parameters investigated during a period of 60 days (30 days of supplementation and 30 days without treatment). Further, there was a significant improvement in the body weight of the rabbits at the end of the experiment. The effect of the three probiotics investigated in this trial was found to be related to the sex of the rabbits and to the intake period (duration). Ultimately, these findings raise the possibility of using probiotics to investigate in an in-depth and specific manner based on fixed factors such as the strain, the gender and age of the animals, the main underlying mechanisms and effects, which would allow achieving optimal and adapted health benefits and sustainable production. In the context of animal production, it is worth investigating in a targeted study the effect of the three strains on muscle growth and development and finding evidence of the possible consequences on meat quality traits of the rabbits supplemented with probiotics.

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“…Numerous diseases including Coronavirus Disease (COVID-19), Irritable Bowel Syndrome (IBD), and kidney disease, which are associated with gastrointestinal disorders, have found that the disruption of gut bacteria may play an important role ( 57 , 58 ). Probiotic strains significantly activate the aromatic hydrocarbon receptor (AhR) way to stimulate the intestinal immune system to relieve GI symptoms ( 59 ). Dimidi et al ( 60 ) revealed that administration of probiotics decreased gut transit time, increased stool frequency, and improved some constipation-related symptoms.…”

Section: Discussionmentioning

confidence: 99%

Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of Randomized Controlled Trials

Jin

Qin

et al. 2022

Front. Nutr.

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BackgroundProbiotics, prebiotics, and synbiotics are three different supplements to treat end stage renal disease (ESRD) patients by targeting gut bacteria. The comprehensive comparison of the effectiveness of different supplements are lacking.ObjectivesThe purpose of this network meta-analysis (NMA) is to assess and rank the efficacy of probiotics, prebiotics, and synbiotics on inflammatory factors, uremic toxins, and gastrointestinal symptoms (GI symptoms) in ESRD patients undergoing dialysis.MethodsRandomized clinical trials were searched from the PubMed, Embase, and Cochrane Register of Controlled Trials databases, from their inception until 4 September 2021. Random-effect model were used to obtain all estimated outcomes in network meta-analysis (NMA). Effect estimates were presented as mean differences (Mean ± SD) with 95% confidence interval (CI). The comprehensive effects of all treatments were ranked by the surface under the cumulative ranking (SUCRA) probabilities.ResultsTwenty-five studies involved 1,106 participants were included. Prebiotics were superior in decreasing Interleukin-6 (IL-6; SMD –0.74, 95% CI [–1.32, –0.16]) and tumor-necrosis factor-α (TNF-α; SMD –0.59, 95% CI [–1.09, –0.08]), synbiotics were more effective in declining C-reactive protein (CRP; SMD –0.69, 95% CI [–1.14, –0.24]) and endotoxin (SMD –0.83, 95% CI [–1.38, –0.27]). Regarding uremic toxins, prebiotics ranked highest in reducing indoxyl sulfate (IS; SMD –0.43, 95% CI [–0.81, –0.05]), blood urea nitrogen (BUN; SMD –0.42, 95% CI [–0.78, –0.06]), and malondialdehyde (MDA; SMD –1.88, 95% CI [–3.02, –0.75]). Probiotics were rated as best in alleviating GI symptoms (SMD: –0.52, 95% CI [–0.93, –0.1]).ConclusionOur research indicated prebiotics were more effective in declining IL-6, TNF-α, IS, MDA, and BUN, synbiotics lowering CRP and endotoxin significantly, and probiotics were beneficial for alleviating GI symptoms, which may contribute to better clinical decisions. This study was registered in PROSPERO (Number: CRD42021277056).Systematic Review Registration[http://www.crd.york.ac.uk/PROSPERO], identifier [CRD42021277056].

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Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome

Cited by 104 publications

References 201 publications

Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers

Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of Randomized Controlled Trials

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