Probiotics: potential pharmaceutical applications

Kaur, Indu Pal; Chopra, Kanwaljit; Saini, Amarpreet

doi:10.1016/s0928-0987(01)00209-3

Cited by 281 publications

(181 citation statements)

References 50 publications

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“…In addition to their purported hypocholesterolemic effect, these bacteria have been hypothesized to enhance the immune response, treat antibiotic or travelers diarrhea, improve gastrointestinal (GI) health and reduce fecal enzymes implicated in cancer initiation (Kaur et al, 2002). Probiotic bacteria are incorporated into dairy foods such as milk and yogurt or packaged as capsules for human consumption.…”

Section: Introductionmentioning

confidence: 99%

Probiotic capsules do not lower plasma lipids in young women and men

et al. 2007

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Objective: To investigate the effect of probiotic capsules on plasma lipids. Design: A randomized, single-blinded, placebo-controlled, parallel-arm trial. Subjects: Fifty-five normocholesterolemic subjects ages 18-36 (33 premenopausal women and 22 men). Intervention: Each subject consumed either three probiotic capsules each containing a total of 10 9 colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10-15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women). Results: Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention. Conclusions: These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men. Sponsorship: Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.

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Section: Introductionmentioning

confidence: 99%

Probiotic capsules do not lower plasma lipids in young women and men

et al. 2007

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“…With a targeted use of specific probiotic strains, it is possible to induce an immune stimulant type of response on both B (increase of humoral immunity) and T lymphocytes (increase of cell-mediated immunity) and on the phagocytic component, particularly on polymorphonuclear cells [37,38]. The ability to stimulate responses of this type is useful in very specific clinical circumstances, for example for immunoprophylaxis of upper respiratory tract infections during winter or, in addition to influenza vaccination, to increase antibody response to vaccine or, more generally, to increase nonspecific immunity surveillance to pathogens of different nature [39,40].…”

Section: Probiotics and The Immune Responsementioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

227

128

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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“…The stability of the probiotic preparations is their key characteristic and therefore viability of probiotics can not be compromised a er oral intake (Kauer et al, 2002;Isolauri et al, 2004).…”

Section: Probiotics Intestinal Microfl Ora Pigs Enterococcus Faeciummentioning

confidence: 99%

Effect of probiotics in the pig nutrition on the pathogenic bacteria counts in the gut

Pospíšková¹,

Zorníková²,

Kolářová³

et al. 2013

Acta Univ. Agric. Silvic. Mendelianae Brun.

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POSPÍŠKOVÁ PAVLA, ZORNÍKOVÁ GABRIELA, KOLÁŘOVÁ MIROSLAVA, SLÁDEK ZBYŠEK, KOMPRDA TOMÁŠ, GERŠIOVÁ JANA: Eff ect of probiotics in the pig nutrition on the pathogenic bacteria counts in the gut. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013, LXI, No. 6, pp. 1839-1843 The objective of the present study was to evaluate the effi cacy of a probiotic culture in the digestive tract of sows. Two groups of healthy sows with 40 animals each were fed a standard feed three weeks a er weaning. From the beginning of the fourth week (day 0), one group received the same diet enriched with the probiotic monoculture of Enterococcus faecium SF 68, the second (control) group was given the same diet without probiotics. The samples of faeces were collected (to the sterile containers) at days 0, 15, 30 (end of the probiotic consumption) and 40 (end of the wash-out period), respectively. In the probiotic group, signifi cant decrease (P < 0.05) of numbers of E. coli and Clostridium spp. in faeces was found. The results indicate a positive eff ect of probiotics consumption on the digestive tract of sows and it can be used for a decrease of the incidence of the diarrhoeic diseases that are frequent in the pig husbandry.

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Probiotics: potential pharmaceutical applications

Cited by 281 publications

References 50 publications

Probiotic capsules do not lower plasma lipids in young women and men

Probiotic capsules do not lower plasma lipids in young women and men

Probiotics and health: An evidence-based review

Effect of probiotics in the pig nutrition on the pathogenic bacteria counts in the gut

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