Probiotics-mediated suppression of cancer

So, Stephanie; Wan, Murphy Lam Yim; El‐Nezami, Hani

doi:10.1097/cco.0000000000000342

Cited by 75 publications

(49 citation statements)

References 78 publications

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“…The study of inhibitory effects of probiotic Lactobacillus on the Growth of Human Colonic Carcinoma Cell Line HT-29 showed that Lactobacillus can inhibit the growth of colonic carcinoma cells and may lead to apoptosis. Live Lactobacillus acidophilus and Lactobacillus rhamnosus GG, Lactobacillus casei, Lactobacillus reuteri has been confirmed to induce apoptotic cell death in both murine and human colon carcinoma cell lines as well as an experimental tumor model [104][105][106][107][108].…”

Section: Prevention and Management Of Cancermentioning

confidence: 99%

New Progress Regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species

Shonyela¹,

Wang²,

Yang³

et al. 2017

J Prob Health

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Lactobacillus species are non-spore-forming, Gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabits the human and animal gastrointestinal and mouth organs. The aim of this review was to evaluate the new progress regarding the use of Lactobacillus species as live delivery vectors, prevention and treatment of pathogenic and metabolic diseases. Lactobacillus strains as probiotics have been extensively studied and have confirmed that they can absolutely improve performance as live delivery vectors, a treatment option of various diseases such as: hemorrhagic cecal coccidiosis in young poultry, Hypertension, avian flu, obesity, diabetes, Derzsy's disease or parvovirus infection, human immunodeficiency virus infections, irritable bowel syndrome, gastrointestinal disorders, Fungal infections, vaginal eubiosis, fish and shellfish species diseases.We give you an idea about that Lactobacillus species have been proficient in preventing and treating both disorders in animal models and some used for clinical trials. We present the most current studies on the use of Lactobacillus strains that had an impact on an effective immune response to a specific antigen because a variety of antigens have been expressed. Therefore Lactobacillus strains can be considered as good candidates because of its potential for diseases treatment and vaccine development as heterologous protein secretion to date.

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Section: Prevention and Management Of Cancermentioning

confidence: 99%

New Progress Regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species

Shonyela¹,

Wang²,

Yang³

et al. 2017

J Prob Health

View full text Add to dashboard Cite

show abstract

“…Disorders ranging from inflammatory diseases to several types of cancer, including colon cancer, are believed to benefit from probiotics (72,73). In fact, a combination of microorganisms seems to act much more efficient than a single microorganism.…”

Section: Microbiota Contribution In Favor Of Tumor Protectionmentioning

confidence: 99%

“…Contribution of microbiota as a health-promoting factor is best exemplified by the administration of probiotics, a group of live microorganisms which are shown to be beneficial for the host (72). Disorders ranging from inflammatory diseases to several types of cancer, including colon cancer, are believed to benefit from probiotics (72,73).…”

Section: Microbiota Contribution In Favor Of Tumor Protectionmentioning

confidence: 99%

“…Multiple mechanisms have been suggested, relating microbiota to colon cancer protection. These mechanisms include alteration of microbiota content, induction of epithelial cell apoptosis, reduced bacterial translocation, improved epithelial defense barrier, modulation of mucosal inflammation, oxidative status, and shift of T cells towards an antitumor phenotype (72,74,76). (77).…”

Section: Microbiota Contribution In Favor Of Tumor Protectionmentioning

confidence: 99%

“…In fact, a combination of microorganisms seems to act much more efficient than a single microorganism. Strains of lactic acid bacteria, particularly Lactobacillus and Bifidobacterium species, are commonly added as probiotics to dairy products such as yogurt (72).…”

Section: Microbiota Contribution In Favor Of Tumor Protectionmentioning

confidence: 99%

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Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

2016

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Colon microbiota, as a complex and diverse population, has been shown to be either pro-or anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.

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