Probiotics—Live Biotherapeutics: a Story of Success, Limitations, and Future Prospects—Not Only for Humans

Zommiti, Mohamed; Chikindas, Michael L.; Ferchichi, Mounir

doi:10.1007/s12602-019-09570-5

Cited by 39 publications

(24 citation statements)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An undeniable feature of probiotic use is the broad spectrum of applications that have resulted in positive animal performance outcomes. Increases in egg and milk production, gut health and disease reduction, leg health and lameness reduction, reproductive health, meat quality and metabolic homeostasis, have all been demonstrated experimentally following feed supplementation with probiotics (Mountzouris et al 2010;Wideman et al 2012;Shini et al 2013Shini et al , 2020bZheng et al 2014Zheng et al , 2016Latorre et al 2015;Bajagai et al 2016;Angelakis 2017;Gadde et al 2017;Cameron and McAllister 2019;Park et al 2020;Wang et al 2020;Zommiti et al 2020). Together, this is a very strong endorsement for the role of probiotics in promoting gut health, and animal health and productivity.…”

Section: Box 1 Necrotic Enteritismentioning

confidence: 96%

“…For poultry, a 'healthy gut' means the absence of abnormal or damaged structures and functions, so that the bird is protected from pathogens and is able to digest feed and absorb nutrients efficiently to achieve optimum performance. There is increasing evidence that probiotics can make an important contribution to keeping a gut healthy by the maintenance of gut homeostasis (Bajagai et al 2016;Cameron and McAllister 2019;Zommiti et al 2020). Optimal gut health is crucial not only for the health, performance and welfare of production animals, but it also contributes to the environment because it improves feed efficiency, reduces use of AGPs, and sustains food safety and human health.…”

Section: Importance Of Gut Healthmentioning

confidence: 99%

See 1 more Smart Citation

Probiotics and gut health: linking gut homeostasis and poultry productivity

Shini

Bryden

2021

Anim. Prod. Sci.

View full text Add to dashboard Cite

The use of probiotics in poultry production has increased rapidly, and this movement has been promoted by global events, such as the prohibition or decline in the use of antibiotic growth promotants in poultry feeds. There has been a persistent search for alternative feed additives, and probiotics have shown that they can restore the composition of the gut microbiota, and produce health benefits to the host, including improvements in performance. Probiotics have shown potential to increase productivity in poultry, especially in flocks challenged by stressors. However, the outcomes of probiotic use have not always been consistent. There is an increasing demand for well defined products that can be applied strategically, and currently, probiotic research is focusing on delineating their mechanisms of action in the gut that contribute to an improved efficacy. In particular, mechanisms involved in the maintenance and protection of intestinal barrier integrity and the role of the gut microbiota are being extensively investigated. It has been shown that probiotics modulate intestinal immune pathways both directly and through interactions with the gut microbiota. These interactions are key to maintaining gut homeostasis and function, and improving feed efficiency. Research has demonstrated that probiotics execute their effects through multiple mechanisms. The present review describes recent advances in probiotic use in poultry. It focuses on the current understanding of gut homeostasis and gut health in chickens, and how it can be assessed and improved through supplementation of poultry diets with probiotics in poultry diets. In particular, cellular and molecular mechanisms involved in the maintenance and protection of gut barrier structure and function are described. It also highlights important factors that influence probiotic efficacy and bird performance.

show abstract

Section: Box 1 Necrotic Enteritismentioning

confidence: 96%

Section: Importance Of Gut Healthmentioning

confidence: 99%

Probiotics and gut health: linking gut homeostasis and poultry productivity

Shini

Bryden

2021

Anim. Prod. Sci.

View full text Add to dashboard Cite

show abstract

“…The genus Enterococcus, Lactobacillus, Pediococcus, Streptococcus, Lactococcus, and Leuconostocos, and also Bacillus are the most used. In addition to bacteria, fungi and yeast strains, mainly from the species of Saccharomyces cerevisiae and kluyveromyces are also used as probiotics [8,19,20]. A microorganism to be considered as a probiotic must meet some requirements: (1) to resist and quickly occupy the intestinal tract; (2) be part of the intestinal habitat; (3) survive the action of digestive enzymes; show antagonistic action against pathogenic microorganisms;(4) be non-toxic and non-pathogenic; (5) be stable and viable in commercial preparation and stimulate the immune system [21].…”

Section: Probiotics In Broilers Concept Types and Effectmentioning

confidence: 99%

“…Antibiotics were widely used as growth promoters, whose application was made in sub-therapeutic doses throughout the breeding of broilers. However, strong evidence indicated that antibiotics contributed to the development of resistance in pathogenic strains [8,9].…”

Section: Introductionmentioning

confidence: 99%

Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

Bahule¹,

Silva²

2021

Advances in Poultry Nutrition Research

View full text Add to dashboard Cite

Feed additives have a strong influence on the production cost of broilers as growth-promoter’s to cover variations in profits due to fluctuation in feed costs. Antibiotics as additives were fundamental and indispensable, however, studies have shown their connection with the emergence of resistant strains of pathogens in animals and humans, therefore in recent years they have been less encouraged. Research is in progress concerning additives that can replace antibiotics as growth promotors and also as prophylactics. It was demonstrated that probiotics, which are living microorganisms and without residual effect’s have a potential to be used as microbials. However, they are not always guaranteed as growth promoters, as there are mechanisms of action regarding their interaction with the host that cannot yet be properly understood. The main advances in the use of probiotics in broilers in recent years, as well as the gaps, challenges, and future perspectives were carefully discussed and analyzed in this study. It was considered as a future premise, the possibility of reviewing the traditional methodologies used to test the hypotheses related to the effect of probiotics in broilers, which may also be extended to other animal species.

show abstract

“…As per culture independent DNA sequence analysis of distal gut, autochthonous Lactobacillus is considered to be at most 1% of the total bacterial population [3]. Various strains of Lactobacillus are used for improving digestion, and absorption of nutrients in humans and livestock [4,5]. Members of the group have been given the generally recognized as safe (GRAS) status by the American FDA (Food and Drug Administration) due to frequent occurrence in fermented food [6].…”

Section: Introductionmentioning

confidence: 99%

Conjugal Transfer of Antibiotic Resistances in Lactobacillus spp.

2021

View full text Add to dashboard Cite

Lactic acid bacteria (LAB) are a heterogeneous group of bacteria which are Gram-positive, facultative anaerobes and nonmotile, non-spore forming, with varied shapes from cocci to coccobacilli and bacilli. Lactobacillus is the largest and most widely used bacterial species amongst LAB in fermented foods and beverages. The genus is a common member of human gut microbiome. Several species are known to provide benefits to the human gut via synergistic interactions with the gut microbiome and their ability to survive the gut environment. This ability to confer positive health effects provide them a status of generally recognized as safe (GRAS) microorganisms. Due to their various beneficial characteristics, other factors such as their resistance acquisition were overlooked. Overuse of antibiotics has made certain bacteria develop resistance against these drugs. Antibiotic resistance was found to be acquired mainly through conjugation which is a type of lateral gene transfer. Several in vitro methods of conjugation have been discussed previously depending on their success to transfer resistance. In this review, we have addressed methods that are employed to study the transfer of resistance genes using the conjugation phenomenon in lactobacilli.

show abstract

Probiotics—Live Biotherapeutics: a Story of Success, Limitations, and Future Prospects—Not Only for Humans

Cited by 39 publications

References 221 publications

Probiotics and gut health: linking gut homeostasis and poultry productivity

Probiotics and gut health: linking gut homeostasis and poultry productivity

Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

Conjugal Transfer of Antibiotic Resistances in Lactobacillus spp.

Contact Info

Product

Resources

About