Probiotics in the treatment of otitis media. The past, the present and the future

Coleman, Andrea; Cervin, Anders

doi:10.1016/j.ijporl.2018.10.023

Cited by 13 publications

(9 citation statements)

References 60 publications

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“…Likewise, the importance of “bacterial biofilm” and its association with persistent otic disease has been observed [ 47 , 48 , 49 ]. The local administration of probiotic bacteria seems to have the ability to inhibit the growth of otopathogens [ 50 ]. It is interesting to consider the relationship of DMT with the nasopharyngeal microbiome and the role in the treatment or prevention of OME.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Nutrients

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Introduction: Otitis media with effusion (OME) is common in pediatric primary care consultations. Its etiology is multifactorial, although it has been proven that inflammation factors mediate and that immunity is in a phase of relative immaturity. The objective of this study was to assess the effects of the Traditional Mediterranean Diet (TMD) modulating inflammation and immunity in patients diagnosed with OME. Materials and Methods: A analysis as a single-group pre-test/post-test was conducted on 40 girls and 40 boys between 18 months and 5 years old. Tympanometry normalization was the main test to control the benefit of diet. Clinical and therapeutic variables were studied through evaluation questionnaires, a quality test of the diet, as well as various anthropometric parameters. Results: At the end of one year, tympanometry had normalized in 85% of patients. The remaining 15% had normal audiometry and/or associated symptoms had decreased. Likewise, episodes of recurrent colds decreased from 5.96 ± 1.41 to 2.55 ± 0.37; bacterial complications of 3.09 ± 0.75 to 0.61 ± 0.06 and persistent nasal obstruction of 1.92 ± 0.27 to 0.26 ± 0.05. The degree of satisfaction of the families with the program was very high. Conclusions: The application of the Traditional Mediterranean Diet could have promising effects in the prevention and treatment of otitis media with effusion.

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Section: Discussionmentioning

confidence: 99%

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Nutrients

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“…This bacterium is a common member of the natural microflora associated with gut and skin, including ear [7,19,53], and its presence has been reported as significantly more abundant in atopic dogs when compared to healthy dogs [19]. We rule out that the presence of Lactobacilli is related to previous treatment with probiotics, since the animals included in the present study did not receive such kind of therapy as an alternative treatment of otitis [54], which is a practice that is gaining interest in veterinary practice.…”

Section: Plos Onementioning

confidence: 97%

Cerumen microbial community shifts between healthy and otitis affected dogs

et al. 2020

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Otitis externa is a common multifactorial disease in dogs, characterized by broad and complex modifications of the ear microbiota. The goal of our study was to describe the ear cerumen microbiota of healthy dogs, within the same animal and between different animals, and to compare the cerumen microbiota of otitis affected dogs with that of healthy animals. The present study included 26 healthy dogs, 16 animals affected by bilateral otitis externa and 4 animals affected by monolateral otitis externa. For each animal cerumen samples from the right and left ear were separately collected with sterile swabs, and processed for DNA extraction and PCR amplification of the 16S rRNA gene. Amplicon libraries were sequenced using an Ion Torrent Personal Genome Machine (PGM), and taxonomical assignment and clustering were performed using QIIME 2 software. Our results indicate that the bacterial community of the cerumen in healthy dogs was characterized by extensive variability, with the most abundant phyla represented by Proteobacteria, Actinobacteria, Firmicutes, Bacteroidetes and Fusobacteria. The analysis of both alpha and beta diversity between pairs of left and right ear samples from the same dog within the group of affected animals displayed higher differences than between paired samples across healthy dogs. Moreover we observed reduced bacterial richness in the affected group as compared with controls and increased variability in population structure within otitis affected animals, often associated with the proliferation of a single bacterial taxon over the others. Moreover, Staphylococcus and Pseudomonas resulted to be the bacterial genera responsible for most distances between the two groups, in association with differences in the bacterial community structure. The cerumen microbiota in healthy dogs exhibits a complex bacterial population which undergoes significant modifications in otitis affected animals.

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“…There are also concerns regarding rising rates of antimicrobial resistance ( 12 ) and the potential for long-term effects of antibiotics early in life ( 13 ). Thus, efforts have recently focused on the identification of candidate bacteria that confer colonization resistance against S. aureus ( 14 – 21 ) and S. pneumoniae ( 22 – 25 ), with particular urgency for S. aureus in the absence of an effective vaccine.…”

Section: Introductionmentioning

confidence: 99%

Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota

Brugger

Eslami²,

Pettigrew

et al. 2020

mSphere

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Multiple epidemiological studies identify Dolosigranulum pigrum as a candidate beneficial bacterium based on its positive association with health, including negative associations with nasal/nasopharyngeal colonization by the pathogenic species Staphylococcus aureus and Streptococcus pneumoniae. Using a multipronged approach to gain new insights into D. pigrum function, we observed phenotypic interactions and predictions of genomic capacity that support the idea of a role for microbe-microbe interactions involving D. pigrum in shaping the composition of human nasal microbiota. We identified in vivo community-level and in vitro phenotypic cooperation by specific nasal Corynebacterium species. Also, D. pigrum inhibited S. aureus growth in vitro, whereas robust inhibition of S. pneumoniae required both D. pigrum and a nasal Corynebacterium together. D. pigrum l-lactic acid production was insufficient to account for these inhibitions. Genomic analysis of 11 strains revealed that D. pigrum has a small genome (average 1.86 Mb) and multiple predicted auxotrophies consistent with D. pigrum relying on its human host and on cocolonizing bacteria for key nutrients. Further, the accessory genome of D. pigrum harbored a diverse repertoire of biosynthetic gene clusters, some of which may have a role in microbe-microbe interactions. These new insights into D. pigrum’s functions advance the field from compositional analysis to genomic and phenotypic experimentation on a potentially beneficial bacterial resident of the human upper respiratory tract and lay the foundation for future animal and clinical experiments. IMPORTANCE Staphylococcus aureus and Streptococcus pneumoniae infections cause significant morbidity and mortality in humans. For both, nasal colonization is a risk factor for infection. Studies of nasal microbiota identify Dolosigranulum pigrum as a benign bacterium present when adults are free of S. aureus or when children are free of S. pneumoniae. Here, we validated these in vivo associations with functional assays. We found that D. pigrum inhibited S. aureus in vitro and, together with a specific nasal Corynebacterium species, also inhibited S. pneumoniae. Furthermore, genomic analysis of D. pigrum indicated that it must obtain key nutrients from other nasal bacteria or from humans. These phenotypic interactions support the idea of a role for microbe-microbe interactions in shaping the composition of human nasal microbiota and implicate D. pigrum as a mutualist of humans. These findings support the feasibility of future development of microbe-targeted interventions to reshape nasal microbiota composition to exclude S. aureus and/or S. pneumoniae.

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Probiotics in the treatment of otitis media. The past, the present and the future

Cited by 13 publications

References 60 publications

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Cerumen microbial community shifts between healthy and otitis affected dogs

Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota

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