Probiotics in the Complex Treatment of Various Diseases of the Gastrointestinal Tract

Ивашкин, К. В.; Reshetova, M. S.; Зольникова, О. Ю.; Korneev, V. R.; Широкова, Е. Н.

doi:10.22416/1382-4376-2020-30-1-42-48

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Механизмы противоопухолевой защиты обнаружены у пробиотических бактерий Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, Lactobacillus plantarum (Lactiplantibacillus plantarum) 299v, L. plantarum, Lacticaseibacillus casei, Bifi dobacterium spp. (в частности, B. longum) и Saccharomyces cerevisiae [24][25][26][27][28][29].…”

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Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Ermolenko,

Alyokhina,

Kashchenko

et al. 2024

jour

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Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of the study was to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and E. hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. The use of autoprobiotics did not cause side effects and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The features of the intestinal microbiome in patients with CRC were revealed, which are fundamentally different from those of other authors by an increase in alpha- biodiversity, lactobacilli, bifidobacteria, Bacteroides thetaiotaomicron and its additional differences associated with the absence of non-pathogenic enterococci: a greater amount of Parvimonas micra, a smaller amount of Akkermansia spp., an increase in the content of Klebsiella sp., Fusobacterium nucleatum and Clostridium perfringens. The use of autoprobiotics led to the elimination of P. micra, a decrease in C. perfringens, which led to the normalization of the microbiota in most patients. The effectiveness of autoprobiotics in the treatment of CRC has been proven, which, apparently, is associated with a change in the composition of intestinal microbiocenosis.

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Section: Introductionunclassified

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Ermolenko,

Alyokhina,

Kashchenko

et al. 2024

jour

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Role of Mucin 2 Glycoprotein and L-fucose in Interaction of Immunity and Microbiome within the Experimental Model of Inflammatory Bowel Disease

Bets

Achasova

Borisova

et al. 2022

Biochemistry Moscow

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Gut microbiota as one of the key regulators of metabolic diseases

2023

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Introdiction. The presence of obesity in a patient or, conversely, malnutrition is accompanied by various metabolic disorders and is the focus of modern medical science and healthcare organizers.Objective. To reveal the mechanism of action (impact on motility through the intestinal microbiota) of the drug mebeverine in the structure of concomitant therapy for IBS.Material and methods. The index of nutritional insufficiency was proposed and calculated by us on the basis of the parameters of the alimentary-volemic diagnosis, expressed in points; up to 29 points – a mild degree of nutritional deficiency (the risk of surgery is minimal, the operation is possible after a short-term infusion preparation); 29–30 points – medium degree (the risk is relatively high, the operation is possible only after at least minimal preliminary infusion-alimentation correction); 31–33 – severe degree of nutritional insufficiency (the risk of surgery is high, surgery can only be performed in an emergency after minimal preparation or planned after a long preparation of the patient for surgery until the nutritional status is increased by 1–2 levels; 34–42 – extremely severe (only emergency surgery or palliative after preliminary preparation, raising, if possible, the nutritional status by 1–2 levels).Rehabilitation potential was determined according to generally accepted formulas. Microbiota was also determined by the traditional method. Electrical activity and the nature of motility were determined by it using a mingograph.Results and discussion. During the examination, it was revealed that the microbiota differs with different HN. At 29–30 points, HH and high RR occur. Rehabilitation potential (RP) has 4 levels of assessment: High rehabilitation potential implies the possibility of achieving a full recovery of healthConclution. Gut microbiota is a key regulator of metabolic disease. When taking mebeverine, it is advisable. Apparently, to apply a detoxification correction, because it is metabolized in the liver. There is no doubt that it is expedient to further study the state of the microbiota in the modern world with various TIN.

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Probiotics in the Complex Treatment of Various Diseases of the Gastrointestinal Tract

Cited by 3 publications

References 19 publications

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Role of Mucin 2 Glycoprotein and L-fucose in Interaction of Immunity and Microbiome within the Experimental Model of Inflammatory Bowel Disease

Gut microbiota as one of the key regulators of metabolic diseases

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