Probiotics in prevention and treatment of obesity: a critical view

Kobyliak, Nazarii; Conte, Caterina; Cammarota, Giovanni; Haley, Andreana P.; Štyriak, Igor; Gašpar, Ľudovít; Fusek, J.; Rodrigo, Luís; Kružliak, Peter

doi:10.1186/s12986-016-0067-0

Cited by 265 publications

(203 citation statements)

References 81 publications

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“…It was also described that some probiotic strain can improve these values near to the non-obese control [39]. In our study, the analysis of the glucose, cholesterol, LDL, HDL and triglycerides values showed increases in the obese control for 30 days and 60 days in relation to the normal control.…”

Section: Resultsmentioning

confidence: 63%

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

Maldonado-Galdeano¹

2017

FSN

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Yogurt is a dairy product made by milk fermented with Lactobacillus bulgaricus and Streptococcus thermophilus. Probiotic bacteria are added to conventional yogurt in order to boost benefits on the consumer health.In present work we studied in an obese mouse model the effect of the yogurt or probiotic yogurt supplementation to the diet on body weight, in biochemical parameters and in the thymus and intestinal immune system improvement. Adult mice received conventional balanced diet or a high-fat diet supplemented with milk, conventional yogurt or probiotic yogurt over 60 d. The body weight and biochemical parameters in serum (glucose, total LDL and HDL-cholesterol and triglycerides) were determined. Small intestine and thymus histology were analyzed. The changes in the gut microbiota, the possible translocation to internal organs and the levels of IgA and cytokines were also investigated. Probiotic yogurt was the most effective supplement for decreasing body weight and normalizing biochemical parameters in serum and in the improvement of small intestine and thymus histology. The gut microbiota showed increased bifidobacteria and recovered the balance of Enterobacteria population in obese mice given probiotic yogurt without translocation to internal organs, showing increases in IgA+ cells and cytokine production in gut. The present study demonstrated the safety and useful of yogurt consumption in obese host, benefiting mainly the innate mucosal immunity, biochemical parameters, intestine and thymus histology. These results allows advance in the research about the influence of functional foods on the thymus cells activity, which play a key role in the immune response.

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Section: Resultsmentioning

confidence: 63%

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

Maldonado-Galdeano¹

2017

FSN

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“…Применение пробиотиков и пребиотиков для улучшения взаимодействия между кишечными микроорганизмами и обменом веществ хозяина при ожирении и других метаболических заболе-ваниях широко исследовано [49].…”

Section: терапевтический потенциал манипулирова-ния кишечной микробиоunclassified

Obesity and Metabolic Syndrome: Pathophysiological Role of Gut Microbiota and Potential of the Alternative Therapy

Айтбаев¹,

Муркамилов²

2017

Kompleks. probl. serdečno-sosud. zabol.

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В обзоре представлены данные, характеризующие современное состояние знаний о связи между ки-шечной микробиотой, ожирением и метаболическим синдромом. Обсуждается патофизиологическая роль кишечной микробиоты в развитии ожирения и метаболического синдрома. Рассматриваются потенциаль-ные возможности альтернативной терапии для контроля потребления энергии и снижения распространён-ности ожирения и метаболического синдрома.Ключевые слова: ожирение, метаболический синдром, кишечная микробиота, субклиническое воспа-ление, транслокация фекальной микробиоты, пробиотики, пребиотики. The review presents data describing the current state of knowledge about the link between gut microbiota, obesity and metabolic syndrome. Pathophysiological role of gut microbiota in the development of obesity and metabolic syndrome is discussed. Potential of alternative therapy in controlling energy consumption and reducing the prevalence of obesity and metabolic syndrome is considered. OBESITY AND METABOLIC SYNDROMEKey words: obesity, metabolic syndrome, gut microbiota, low-grade inflammation, fecal microbiota transplantation, probiotics, prebiotics. НИИ КПССЗ имеет большой опыт в разработке изделий для сердечно-сосудистой хирургии, в частности биопротезов кла-нов сердца и сосудов. С 2010 года под руководством академика РАН л. С. Барбараша начаты исследования по созданию био-зорбируемых сосудистых протезов малого диаметра. Основная цель -создание полимерных конструкций с бионаправленным йствием, способных заменить отдельные структуры живого организма, в частности сердечно-сосудистой системы. Научная но-зна поставленной задачи заключается в использовании нового подхода создания органа непосредственно в организме пациента счет биофункциональности и биорезорбируемости полимерных конструкций. доказана долгосрочная проходимость полимерных судистых графтов на основе поликапролактона и композиции полигидроксибутирата/валерата и поликапролактона. В экспери-нтах in vitro доказано, что ростовые факторы, инкорпорируемые в состав биодеградируемых графтов, сохраняют свою био-гическую активность. В долгосрочных экспериментах in vivo доказано, что сосудистый эндотелиальный фактор роста ускоряет дотелизацию и улучшает проходимость биодеградируемых полимерных сосудистых графтов.Ключевые слова: биодеградируемые полимеры, сосудистый графт, ростовые факторы. RICICd has large experience in the development of products for cardiovascular surgery, in particular, the bioprosthesis heart valves d blood vessels. Since 2010, under the leadership of the academician of RAS L. S. Barbarash researches to create bioresorbable scular prostheses of small diameter began. the primary purpose -to create polymer structures with bio-directed action capable to lace individual structures of a living organism, in particular, of cardiovascular system. Scientific novelty of the problem lies in using a new proach for creation an organ directly in the patient's body by biofunctional and bioresorbable features of polymer structures. the long-term tency of PCL vascular grafts and PHBV and P...

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“…Akkermansia muciniphila has proved novel mechanism of action governing beneficial effects for obesity. [18,19].…”

Section: VIIImentioning

confidence: 99%

Facts about Probiotics

Al-Saeed¹

2017

JPNC

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Numerous claimed benefits of using probiotics invade the Media. However, Health Authorities in charge rejected all petitions of health claims due to lack of supportive research. Reaching a final decision about this issue seems not easy, with thousands of articles and researches about probiotics in medical literature present similar illusive view. In this paper, we try to illustrate some of the unbiased studies about probiotics possible benefits. It seems that each effect of probiotics is strain specific .so, generalization deepens that contradiction. Probiotic is considered a promising biologic medication that worth more research and strain -disease relationship understanding. Facts about Probiotics 2/3

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Probiotics in prevention and treatment of obesity: a critical view

Cited by 265 publications

References 81 publications

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

Obesity and Metabolic Syndrome: Pathophysiological Role of Gut Microbiota and Potential of the Alternative Therapy

Facts about Probiotics

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