Probiotics in bariatric surgery ensure greater lipids and glycemic profile with no effect on anthropometric measurements and inflammatory markers: A systematic review and meta-analysis of RCT

Daghmouri, Mohamed Aziz; Chaouch, Mohamed; Yang, Wah; Akremi, Soumaya; Jaoua, Hazem; Fadhel, Kamel Ben; Gouader, Amine; Reißfelder, Christoph; Elhadedy, Hazem; Rahbari, Nuh N.; Oweira, Hani

doi:10.1016/j.soda.2022.100061

Cited by 3 publications

(2 citation statements)

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“…In our pilot study of patients who underwent bariatric surgery, we did not appreciate a clinical or statistically significant difference in the mean rate of weight loss between the groups who received LGG versus placebo. Our study findings are in keeping with results demonstrated by a systematic review and meta-analysis of 5 randomized controlled trials including a total of 279 patients after bariatric surgery in which no significant difference in percent excess weight loss at 3 months, change in BMI, waist circumference change or fat mass change was noted between the probiotic and placebo groups [26]. However, it should be noted that if there were some minor impact of oral probiotics on weight loss, this may be masked by the substantial effect of bariatric surgery on weight loss, resulting in no measurable difference between the two groups.…”

Section: Resultssupporting

confidence: 91%

Impact of Lactobacillus GG on weight loss in post-bariatric surgery patients: a randomized, double-blind clinical trial

Nasir,

Stone,

Mahoney

et al. 2024

Preprint

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Introduction and Objectives: There is increasing evidence suggesting the impact of human gut microbiota on digestion and metabolism. It is hypothesized that the microbiome in obese subjects is more efficient than that in lean subjects in absorbing energy from food, thus predisposing to weight gain. A transformation in gut microbiota has been demonstrated in patients who have undergone bariatric surgery which has been positively associated with post-surgical weight loss. However, there is lack of studies investigating the impact of probiotics on weight loss in post-bariatric surgery patients. The objectives of our study were to investigate the impact of a probiotic, Lactobacillus GG (LGG), on weight loss and quality of life in patients who have undergone bariatric surgery. Methods: The study was registered with ClinicalTrials.govNCT01870544. Subjects were randomized to receive either LGG or placebo capsules. Percent total weight loss at their post-operative visits was calculated and differences between the two groups were tested using a t-test with unequal variances. The effect of LGG on Gastrointestinal Quality of Life Index (GIQLI) scores was estimated using a mixed model repeated measures model. Results: The mean rate of change in percent total weight loss at the ‘30-day’ post-operative visit for the placebo and treatment groups was 0.098 and 0.079 (p = 0.41), respectively, whereas that at the ‘90-day’ post-operative visit was 0.148 and 0.126 (p = 0.18), respectively. The difference in GIQLI scores on ’30-day’ and ’90-day’ visits were 0.5 (-7.1, 8.0), p=0.91 and 3.7 (-4.9, 12.3), p=0.42, respectively. LGG was recovered from the stools of 3 out of 5 subjects in the treatment group.. Conclusion: We did not appreciate a significant difference in the mean rate of weight loss or GIQLI scores between the groups who received LGG versus placebo. This study demonstrated survival of lactobacillus during transit through the gastrointestinal tract.

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Section: Resultssupporting

confidence: 91%

Impact of Lactobacillus GG on weight loss in post-bariatric surgery patients: a randomized, double-blind clinical trial

Nasir,

Stone,

Mahoney

et al. 2024

Preprint

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“…The research primarily concentrated on obese individuals with NAFLD aged one day to 85 years old. The main measured indicators were body weight ( 23 , 28 , 56 , 59 , 69 – 85 ), BMI ( 23 , 28 , 56 , 59 , 60 , 65 , 69 – 82 , 84 – 105 ), WC ( 28 , 68 , 70 , 72 , 75 , 79 – 81 , 85 , 87 , 90 , 93 , 94 , 99 , 101 ), hip circumference (HC) ( 90 ), waist to hip ratio (WHR) ( 78 , 80 , 90 , 94 ), body fat percent (BF%) ( 71 , 75 , 80 , 85 , 90 , 94 ), and BFM ( 56 , 61 , 71 , 72 , 75 , 80 , 81 , 90 ). Probiotic supplementation significantly reduced weight, BMI, WC, BF%, and BFM across most studies.…”

Section: Resultsmentioning

confidence: 99%

The effects of prebiotic, probiotic or synbiotic supplementation on overweight/obesity indicators: an umbrella review of the trials’ meta-analyses

Rasaei,

Heidari,

Esmaeili

et al. 2024

Front. Endocrinol.

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BackgroundThere is controversial data on the effects of prebiotic, probiotic, or synbiotic supplementations on overweight/obesity indicators. Thus, we aimed to clarify this role of biotics through an umbrella review of the trials’ meta-analyses.MethodsAll meta-analyses of the clinical trials conducted on the impact of biotics on overweight/obesity indicators in general populations, pregnant women, and infants published until June 2023 in PubMed, Web of Sciences, Scopus, Embase, and Cochrane Library web databases included. The meta-analysis of observational and systematic review studies without meta-analysis were excluded. We reported the results by implementing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) flowchart. The Assessment of Multiple Systematic Reviews-2 (AMSTAR2) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) systems were used to assess the methodological quality and quality of evidence.ResultsOverall, 97 meta-analysis studies were included. Most studies were conducted on the effect of probiotics in both genders. Consumption of prebiotic: 8-66 g/day, probiotic: 104 -1.35×1015 colony-forming unit (CFU)/day, and synbiotic: 106-1.5×1011 CFU/day and 0.5-300 g/day for 2 to 104 weeks showed a favorable effect on the overweight/obesity indicators. Moreover, an inverse association was observed between biotics consumption and overweight/obesity risk in adults in most of the studies. Biotics did not show any beneficial effect on weight and body mass index (BMI) in pregnant women by 6.6×105-1010 CFU/day of probiotics during 1-25 weeks and 1×109-112.5×109 CFU/capsule of synbiotics during 4-8 weeks. The effect of biotics on weight and BMI in infants is predominantly non-significant. Prebiotics and probiotics used in infancy were from 0.15 to 0.8 g/dL and 2×106-6×109 CFU/day for 2-24 weeks, respectively.ConclusionIt seems biotics consumption can result in favorable impacts on some anthropometric indices of overweight/obesity (body weight, BMI, waist circumference) in the general population, without any significant effects on birth weight or weight gain during pregnancy and infancy. So, it is recommended to intake the biotics as complementary medications for reducing anthropometric indices of overweight/obese adults. However, more well-designed trials are needed to elucidate the anti-obesity effects of specific strains of probiotics.

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Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

Wang,

Zheng,

Kuang

et al. 2023

Int J Obes

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Background Probiotics are commonly used after bariatric surgery. However, uncertainty remains regarding their effects. The purpose of this systematic review was to assess the effect of probiotics in patients with morbid obesity undergoing bariatric surgery. Methods PubMed, Cochrane Library, Embase, Science Direct, and Web of Science were searched from inception to April 4, 2023. No language restrictions were applied. Relevant randomized controlled trials and controlled clinical trials were included. We used the aggregated data extracted from the trials and assessed the heterogeneity. When severe heterogeneity was detected, a random effect model was used. All stages of the review were done by independent authors. Results We screened 2024 references and included 11 randomized controlled trials and controlled clinical trials. Compared with the protocol groups, probiotics showed significant effects on regulating aspartate amino transferase level (MD = −4.32 U/L; 95% CI [−7.10, −1.53], p = 0.002), triglycerides (MD = −20.16 mg/dL; 95% CI [−34.51, −5.82], p = 0.006), weight (MD = −1.99 kg; 95% CI [−3.97, −0.01], p = 0.05), vitamin B12 (MD = 2.24 pg/dL; 95% CI [−0.02, 4.51], p = 0.05), dietary energy (MD = −151.03 kcal; 95% CI [−215.68, −86.37], p < 0.00001), dietary protein (MD = −4.48 g/day, 95% CI [−8.76, −0.20], p = 0.04), dietary carbohydrate (MD = −34.25 g/day, 95% CI [−44.87, −23.62], p < 0.00001), and dietary fiber (MD = −2.17 g/day, 95% CI [−3.21, −1.14], p < 0.0001). There were no severe side effects related to probiotics. Conclusions Our meta-analysis suggested that probiotics may delay the progression of liver function injury, improve lipid metabolism, reduce weight, and reduce food intake, although the effects on other indicators were insignificant. Probiotics may be helpful for patients undergoing bariatric surgery. The review was registered on PROSPERO (International prospective register of systematic reviews): CRD42023407970. No primary source of funding.

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Probiotics in bariatric surgery ensure greater lipids and glycemic profile with no effect on anthropometric measurements and inflammatory markers: A systematic review and meta-analysis of RCT

Cited by 3 publications

References 36 publications

Impact of Lactobacillus GG on weight loss in post-bariatric surgery patients: a randomized, double-blind clinical trial

Impact of Lactobacillus GG on weight loss in post-bariatric surgery patients: a randomized, double-blind clinical trial

The effects of prebiotic, probiotic or synbiotic supplementation on overweight/obesity indicators: an umbrella review of the trials’ meta-analyses

Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

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