Probiotics for the Treatment of Infantile Colic: A Systematic Review

Bird, Anna Schreck; Gregory, Philip J.; Jalloh, Mohamed A.; Cochrane, Zara Risoldi; Hein, Darren J.

doi:10.1177/0897190016634516

Cited by 75 publications

(61 citation statements)

References 14 publications

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“…Biogaia ProTectis contains a single strain of L. reuteri (the same strain described in the meta-analysis) 22 , is available as a liquid drop either with or without added Vitamin D, and has been shown in several studies of term infants to decrease colic. 110 An alternative would be to encourage the motivated parents to take a probiotic product themselves in hopes of transmitting the desired microbes to their infant. 111 …”

Section: Which Probiotic To Prevent Nec?mentioning

confidence: 99%

Impact of probiotics on necrotizing enterocolitis

Underwood

2017

Seminars in Perinatology

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A large number of randomized placebo-controlled clinical trials and cohort studies have demonstrated a decrease in the incidence of necrotizing enterocolitis with administration of probiotic microbes. These studies have prompted many neonatologists to adopt routine prophylactic administration of probiotics while others await more definitive studies and/or probiotic products with demonstrated purity and stable numbers of live organisms. Cross-contamination and inadequate sample size limit the value of further traditional placebo-controlled randomized controlled trials. Key areas for future research include mechanisms of protection, optimum probiotic species or strains (or combinations thereof) and duration of treatment, interactions between diet and the administered probiotic, and the influence of genetic polymorphisms in the mother and infant on probiotic response. Next generation probiotics selected based on bacterial genetics rather than ease of production and large cluster-randomized clinical trials hold great promise for NEC prevention.

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Section: Which Probiotic To Prevent Nec?mentioning

confidence: 99%

Impact of probiotics on necrotizing enterocolitis

Underwood

2017

Seminars in Perinatology

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“…It has been hypothesized that perinatal manipulation of gut microbiota by probiotics supplementation can result in a decrease of gastrointestinal functional symptoms [6]. …”

Section: Introductionmentioning

confidence: 99%

Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial

et al. 2016

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Background: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. Aim: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns. The safety of maternal probiotic administration on neonatal growth pattern and gastrointestinal symptoms were also evaluated. Methods: In a double-blind, placebo-controlled, randomized trial, 66 women took either the probiotic (n = 33) or a placebo (n = 33) daily. Levels of interleukins (IL-6, IL-10 and IL-1β), transforming growth factor-β1 (TGF-β1), and sIgA in breast milk; and the level of sIgA and lactoferrin in newborn stool samples were analyzed at birth and then again at one month of life. Antropometrical evaluation and analysis of gastrointestinal events in newborns was also performed. Results: Probiotic maternal consumption had a significant impact on IL6 mean values in colostrum and on IL10 and TGF-β1 mean values in mature breast milk. Fecal sIgA mean values were higher in newborns whose mothers took the probiotic product than in the control group. Probiotic maternal supplementation seems to decrease incidence of infantile colic and regurgitation in infants. Conclusion: High-dose multi-strain probiotic administration to women during pregnancy influences breast milk cytokines pattern and sIgA production in newborns, and seems to improve gastrointestinal functional symptoms in infants.

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“…One of the most promising new advances in the management of infant colic is using probiotics to modulate the gut microbiota, especially Lactobacillus reuteri (DSM 17938), which has been proven to be effective in breast-fed infants with colic (8). However, it is intriguing that the largest trial so far, and the only study to include formula-fed infants, is the only one that has showed Lactobacillus reuteri to be ineffective in treating colic (9).…”

Section: Infant Colic Is Still a Mysterious Disorder Of The Microbiotmentioning

confidence: 96%