Probiotics for Rectal Volume Variation During Radiation Therapy for Prostate Cancer

Ki, Yongkan; Kim, Wontaek; Nam, Jiho; Kim, Dong-Hyun; Lee, Juhye; Park, Dahl; Jeon, Hosang; Ha, Honggu; Kim, Taenam; Kim, Dong-Won

doi:10.1016/j.ijrobp.2013.07.038

Cited by 22 publications

(35 citation statements)

References 19 publications

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“…Therefore, the importance of establishing an individual's baseline dietary intake, providing a target that can be realistically achieved, and the resources to monitor and analyze this should not be underestimated. 27,30 A significant reduction in volume and percentage change in rectal volume during treatment was found using probiotics 10 (Table 4). However, while probiotics are easy to administer, the optimal dose, bacterial strains used, and their effect on microbiota through radiation therapy treatment have yet to be clearly established.…”

Section: Discussionmentioning

confidence: 95%

“…Ten of the 18 studies employed more than 1 intervention limiting the conclusions that can be drawn from them 8,9,11,14,16,[19][20][21][22][23] (Table 1). Eleven studies reported significant results [8][9][10][11][12][15][16][17][18]20 (Tables 2-5). …”

Section: Rectal Emptying Strategiesmentioning

confidence: 99%

“…Small numbers of patients(10) • PM N 5 mm = 56% • Rectal CSA = 11.5 cm 3 Enemas• Magnitude of PM reduced • Small numbers of patients (10) • Mean rectal CSA reduced • reductions of shifts seen but not clinically significant • PM: Mean (SD) (mm). RL = Prostate motion less than published results• 9 of 17 (53%) patients required additional rectal emptying procedure.…”

mentioning

confidence: 99%

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A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients

McNair

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et al. 2014

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Section: Discussionmentioning

confidence: 95%

Section: Rectal Emptying Strategiesmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients

McNair

Wedlake

Lips

et al. 2014

Practical Radiation Oncology

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“…Concerning inter-fraction motion, Oates et al could not demonstrate any significant difference in favor of a diet associated to psyllium but observed a trend toward rectal volume reduction (50). A randomized trial including 40 patients studied the use of probiotics, such as Lactobacillus acidophilus , and reported a significant reduction in rectal volume variations over the treatment course (51). Evaluations on other molecules preventing the production of intestinal gas, such as the alpha-galactosidase, are ongoing (52).…”

Section: Preventive Corrective and Stabilizing Approaches To Limit mentioning

confidence: 99%

Post-Prostatectomy Image-Guided Radiotherapy: The Invisible Target Concept

et al. 2017

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In the era of intensity-modulated radiation therapy, image-guided radiotherapy (IGRT) appears crucial to control dose delivery and to promote dose escalation while allowing healthy tissue sparing. The place of IGRT following radical prostatectomy is poorly described in the literature. This review aims to highlight some key points on the different IGRT techniques applicable to prostatic bed radiotherapy. Furthermore, methods used to evaluate target motion and to reduce planning target volume margins will also be explored.

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“…Other non-invasive strategies use a rectum-emptying approach, by means of laxatives, anti-flatulence diet [6], bowel relaxant [4], probiotics [7], enemas [8], rectum-emptying tube [9], self evacuation [10], or combination of these. However the degree of effectiveness of each of these methods and identification of the most successful approach is still debatable.…”

Section: Introductionmentioning

confidence: 99%

The effect of bowel preparation regime on interfraction rectal filling variation during image guided radiotherapy for prostate cancer

et al. 2017

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BackgroundThis study aimed to investigate the tolerability and impact of milk of magnesia (MoM) on interfraction rectal filling during prostate cancer radiotherapy.MethodsTwo groups were retrospectively identified, each consisting of 40 patients with prostate cancer treated with radiotherapy to prostate+/-seminal vesicles, with daily image-guidance in 78Gy/39fractions/8 weeks. The first-group followed anti-flatulence diet with MoM started 3-days prior to planning-CT and continued during radiotherapy, while the second-group followed the same anti-flatulence diet only. The rectum between upper and lower limit of the clinical target volume (CTV) was delineated on planning-CT and on weekly cone-beam-CT (CBCT). Rectal filling was assessed by measurement of anterio-posterior diameter of the rectum at the superior and mid levels of CTV, rectal volume (RV), and average cross-sectional rectal area (CSA; RV/length).ResultsOverall 720 images (80 planning-CT and 640 CBCT images) from 80 patients were analyzed. Using linear mixed models, and after adjusting for baseline values at the time of planning-CT to test the differences in rectal dimensions between both groups over the 8-week treatment period, there were no significant differences in RV (p = 0.4), CSA (p = 0.5), anterio-posterior diameter of rectum at superior (p = 0.4) or mid level of CTV (p = 0.4). In the non-MoM group; 22.5% of patients had diarrhea compared to 60% in the MoM group, while 40% discontinued use of MoM by end of radiotherapy.ConclusionThe addition of MoM to antiflatulence diet did not reduce the interfraction variation in rectal filling but caused diarrhea in a substantial proportion of patients who then discontinued its use.

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Probiotics for Rectal Volume Variation During Radiation Therapy for Prostate Cancer

Cited by 22 publications

References 19 publications

A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients

A systematic review: Effectiveness of rectal emptying preparation in prostate cancer patients

Post-Prostatectomy Image-Guided Radiotherapy: The Invisible Target Concept

The effect of bowel preparation regime on interfraction rectal filling variation during image guided radiotherapy for prostate cancer

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