Probiotics for preventing gestational diabetes

Davidson, Sarah J; Barrett, Helen L.; Price, Sarah; Callaway, Leonie K.; Nitert, Marloes Dekker

doi:10.1002/14651858.cd009951.pub3

Cited by 35 publications

(27 citation statements)

References 81 publications

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“…Poor maternal mental health has been associated with various pregnancy and child health complications. On the other hand, a recent review [ 76 ] warned that there could be an increased risk of pre-eclampsia with probiotic administration for the prevention of gestational diabetes, therefore, caution is necessary.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Direct or Indirect Use of Probiotics for the Improvement of Maternal Depression during Pregnancy and in the Postnatal Period: A Systematic Review and Meta-Analysis

et al. 2022

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The mother and infant form a unique bond, with maternal mental health affecting the interactions with the infant and infant behaviours impacting maternal mental health. One of the possible mechanisms influencing maternal mental health is the manipulation of the gut-brain axis by consuming probiotic supplements. Probiotics can also have an indirect influence on maternal mental health via the modulation of the infant microbiome and consequently improving the infant’s health and thus, indirectly leading to an improvement in maternal mood. This systematic review evaluated the efficacy of probiotics on maternal mental health by searching for randomised controlled trials via international databases: Cochrane Library, PubMed, Scopus, ScienceDirect, and Web of Science until January 2022. A meta-analysis was performed using the Cochrane Collaboration methodology where possible. We found seven clinical trials that included the word probiotics and addressed maternal depression and/or anxiety. Of these, five trials investigated the influence of maternal probiotic supplementation on the gut-brain axis. Two trials investigated the indirect influence of probiotics on maternal depression via supplementation of probiotics by infants and subsequent influence on the crying of colicky infants. Meta-analysis of two studies of pregnant and postnatal women and two studies of infants consuming probiotics on the outcome of the Edinburgh Postnatal Depression Scale for mothers showed no statistical difference. The findings indicate that maternal depression is very complex and is influenced by various bidirectional factors. One of the factors that can improve maternal mental health is probiotics, however, careful consideration must be given to correct strain selection as strain-specific effectiveness was observed. Further well-designed, robust clinical studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Direct or Indirect Use of Probiotics for the Improvement of Maternal Depression during Pregnancy and in the Postnatal Period: A Systematic Review and Meta-Analysis

et al. 2022

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“…Godfrey 2021 [ 27 ], however, found the combination of 4 g MI plus vitamin D/B6/B12, riboflavin, zinc, and probiotics was not effective in an international, multi-center, double-blind trial. Previous studies have suggested that vitamin D supplementation could possibly reduce the risk of GDM [ 28 ], while the effect of probiotics remained unclear [ 29 ]. Whether the other components of the intervention played an additional role is yet to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2022

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This study was aimed at assessing the efficacy and safety of inositol nutritional supplementation during pregnancy for the prevention of GDM. PubMed, Embase, MEDLINE, and Cochrane library were systematically searched for randomized controlled trails (RCTs) in this field until May 2022. Primary outcomes were the incidence for GDM and plasma glucose levels by oral glucose tolerance test (OGTT). Pooled results were expressed as relative risk (RR) or mean difference (MD) with a 95% confidence interval (95% CI). Seven RCTs with 1321 participants were included in this study. Compared with the control group, 4 g myo-inositol (MI) supplementation per day significantly decreased the incidence of GDM (RR = 0.30, 95% CI (0.18, 0.49), p < 0.00001). It significantly decreased the plasma glucose levels of OGTT regarding fasting-glucose OGTT (MD = −4.20, 95% CI (−5.87, −2.54), p < 0.00001), 1-h OGTT (MD = −8.75, 95% CI (−12.42, −5.08), p < 0.00001), and 2-h OGTT (MD = −8.59, 95% CI (−11.81, −5.83), p < 0.00001). It also decreased the need of insulin treatment, and reduced the incidence of preterm delivery and neonatal hypoglycemia. However, no difference was observed between 1.1 g MI per day plus 27.6 mg D-chiro-inositol (DCI) per day and the control group regarding all evaluated results. In conclusion, 4 g MI nutritional supplementation per day during early pregnancy may reduce GDM incidence and severity, therefore may be a practical and safe approach for the prevention of GDM.

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“…However, the exact mechanisms by which probiotics may affect GDM remain unknown. Furthermore, some studies have shown no evidence that probiotics administration decreases the risk of GDM any more than placebos [126] , [127] , and another study suggests that probiotics ( L. rhamnosus and B. animalis subspecies lactis ) had limited ability to prevent GDM in overweight and obese pregnant women [128] . Effects of microbiomes and probiotics on female reproduction were briefly summarized in Table 2 .…”

Section: Female Reproductive Microbiomementioning

confidence: 99%

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Feng

Liu

2022

Computational and Structural Biotechnology Journal

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Probiotics for preventing gestational diabetes

Cited by 35 publications

References 81 publications

Efficacy of Direct or Indirect Use of Probiotics for the Improvement of Maternal Depression during Pregnancy and in the Postnatal Period: A Systematic Review and Meta-Analysis

Efficacy of Direct or Indirect Use of Probiotics for the Improvement of Maternal Depression during Pregnancy and in the Postnatal Period: A Systematic Review and Meta-Analysis

Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

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