Probiotics for preventing acute upper respiratory tract infections

Lu, Zejun; Dong, Bi Rong; Huang, Chang Quan; Wu, Taixiang

doi:10.1002/14651858.cd006895

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…In the first trial, vitamin C was associated with echinacea and propolis, but in the second trial, it was associated with probiotics. Echinacea was found to be ineffective in decreasing the incidence and duration of upper respiratory tract infections; probiotics, on the other hand, showed better effects than placebo at stopping these illnesses with a low indication level [24][25][26] . These results are difficult to comprehend.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of the Effectiveness of Vitamin C in the Prevention and Treatment of Childhood Upper Respiratory Tract Infections

Saeed

Abdelrahim

2023

JCNR

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Background: The effectiveness of vitamin C in the prevention and treatment of pediatric upper respiratory tract infections was evaluated in a meta-analysis. Methods: A total 2,573 children with upper respiratory tract infections were included in the meta-analysis, 1,280 of whom received vitamin C and 1,293 who received control medication. The analysis of findings related to the studies included was done through random or fixed effects model to determine whether vitamin C supplementation could stop and control upper respiratory tract infections in children using mean difference (MD) with 95% confidence intervals (CIs). Results: On average, vitamin C-treated children had fewer upper respiratory tract infection bouts, their illness lasted shorter (MD -0.84; 95% CI -1.47 to -0.20, P = 0.009), and they were less contagious than the control. Conclusions: The number of episodes and illness duration of upper respiratory tract-infected pediatric subjects were considerably reduced in the intervention group (vitamin C) compared to the control. Due to the small sample size in four of 11 studies and the limited number of studies included for comparison, the outcomes should be carefully examined.

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Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of the Effectiveness of Vitamin C in the Prevention and Treatment of Childhood Upper Respiratory Tract Infections

Saeed

Abdelrahim

2023

JCNR

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“…Viruses are the most frequent cause of upper respiratory tract infections. A Cochrane review (twelve RCT with 3720 participants, including children and adults) showed that probiotics were superior to placebo in decreasing the number of participants experiencing episodes of acute upper respiratory tract infections, mean duration of an episode of acute upper respiratory tract infections, antibiotic use and cold-related school absenteeism (95) . In influenza viral infection, probiotics have been shown to modulate respiratory immunity and had a beneficial impact on virus clearance and inflammatory-mediated lung injury (96) .…”

Section: Antiviral Effects Of Probioticsmentioning

confidence: 99%

“…The probiotics, such as Lactobacillus and Bifidobacterium, possibly act at multiple levels in this cascade of COVID-19. They act through antiviral actions (86)(87)(88)(89)(90)(91)(92)(93)(94)(95)(96) , restoration of the gut microbiome (55,(58)(59)(60)(61)(62)(63)(64)(65)(66)80,81) , modulation of inflammation/cytokine storm (anti-inflammatory) (55,62,63,65,66,(82)(83)(84)(85) and prevention of secondary bacterial and fungal infections (52)(53)(54)(69)(70)(71)(72)(73)(74)(75) (Fig. 1).…”

Section: The Rationale For Using Probiotics In Coronavirus Disease 2019mentioning

confidence: 99%

Probiotics and Coronavirus disease 2019: think about the link

Angurana

Bansal

2020

Br J Nutr

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The pandemic of Coronavirus disease 2019 (COVID-19) is rapidly progressing, causing significant morbidity and mortality. Various antiviral drugs, anti-inflammatory drugs, and immunomodulators have been tried without substantial clinical benefits. The severe and critical cases of COVID-19 disease are characterised by gut microbiome dysbiosis, immune dysregulation, hyper-inflammation, and hypercytokinemia (cytokine storm). Therefore, the strategies which target these pathophysiological processes may be beneficial. Probiotics are one such strategy that exerts beneficial effects by manipulation of the gut microbiota, suppression of opportunistic pathogens in the gut, decrease translocation of opportunistic organisms, activate mucosal immunity, and modulation of the innate and adaptive immune response. Probiotics are the potential candidates to be tested in moderate and severe cases of COVID-19 due to several beneficial effects, including easy availability, easy to administer, and safe, and economical to use.

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