Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis

Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters

“…Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42]. In our study, a decrease in serum uric acid concentrations in the hamsters treated with microencapsulated L. fermentum ATCC 11976 reflects the corresponding increase in insulin sensitivity and thereby, improvement in liver histopathology.…”

“…NAFLD is also characterized by elevated serum uric acid levels, an independent predictor of NAFLD since they increase progressively with the presence and severity of fibrosis [5], [42]. Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42].…”

Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters

“…Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42]. In our study, a decrease in serum uric acid concentrations in the hamsters treated with microencapsulated L. fermentum ATCC 11976 reflects the corresponding increase in insulin sensitivity and thereby, improvement in liver histopathology.…”

“…NAFLD is also characterized by elevated serum uric acid levels, an independent predictor of NAFLD since they increase progressively with the presence and severity of fibrosis [5], [42]. Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42].…”

Therapeutic options in pediatric non alcoholic fatty liver disease: current status and future directions

“…Loguercio and colleagues have shown that probiotics may reduce NAFLD liver injury and may improve liver function tests [43]. The Cochrane review [44] and a subsequent pediatric meta-analysis [3] however have highlighted that probiotics treatment in patients with NAFLD and non alcoholic steatohepatitis could not be recommended because of the lack of randomized clinical trials. More recently a double-blind RCT showed that the treatment with 500 million of Lactobacillus bulgaricus and Streptococcus thermophiles/day in adults with biopsy-proven NAFLD causes a reduction of liver transaminases level [45].…”

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

“…While these preclinical studies are promising, there are only small clinical trails carried out in NASH patients. These studies have shown some beneficial effects of VSL#3 treatment highlighting the need for controlled clinical trials [52] .…”

Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters

“…Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42]. In our study, a decrease in serum uric acid concentrations in the hamsters treated with microencapsulated L. fermentum ATCC 11976 reflects the corresponding increase in insulin sensitivity and thereby, improvement in liver histopathology.…”

“…NAFLD is also characterized by elevated serum uric acid levels, an independent predictor of NAFLD since they increase progressively with the presence and severity of fibrosis [5], [42]. Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42].…”

Therapeutic options in pediatric non alcoholic fatty liver disease: current status and future directions

“…Loguercio and colleagues have shown that probiotics may reduce NAFLD liver injury and may improve liver function tests [43]. The Cochrane review [44] and a subsequent pediatric meta-analysis [3] however have highlighted that probiotics treatment in patients with NAFLD and non alcoholic steatohepatitis could not be recommended because of the lack of randomized clinical trials. More recently a double-blind RCT showed that the treatment with 500 million of Lactobacillus bulgaricus and Streptococcus thermophiles/day in adults with biopsy-proven NAFLD causes a reduction of liver transaminases level [45].…”

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

“…While these preclinical studies are promising, there are only small clinical trails carried out in NASH patients. These studies have shown some beneficial effects of VSL#3 treatment highlighting the need for controlled clinical trials [52] .…”

Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters

“…Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42]. In our study, a decrease in serum uric acid concentrations in the hamsters treated with microencapsulated L. fermentum ATCC 11976 reflects the corresponding increase in insulin sensitivity and thereby, improvement in liver histopathology.…”

“…NAFLD is also characterized by elevated serum uric acid levels, an independent predictor of NAFLD since they increase progressively with the presence and severity of fibrosis [5], [42]. Elevated uric acid serum levels in NAFLD is within the context of insulin resistance since urinary uric acid clearance decreases in proportion to increases in insulin resistance, leading to an increase in serum uric acid concentration [42].…”

Therapeutic options in pediatric non alcoholic fatty liver disease: current status and future directions

“…Loguercio and colleagues have shown that probiotics may reduce NAFLD liver injury and may improve liver function tests [43]. The Cochrane review [44] and a subsequent pediatric meta-analysis [3] however have highlighted that probiotics treatment in patients with NAFLD and non alcoholic steatohepatitis could not be recommended because of the lack of randomized clinical trials. More recently a double-blind RCT showed that the treatment with 500 million of Lactobacillus bulgaricus and Streptococcus thermophiles/day in adults with biopsy-proven NAFLD causes a reduction of liver transaminases level [45].…”

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

“…While these preclinical studies are promising, there are only small clinical trails carried out in NASH patients. These studies have shown some beneficial effects of VSL#3 treatment highlighting the need for controlled clinical trials [52] .…”