Probiotics for managing caries and periodontitis: Systematic review and meta-analysis

Grüner, D; Paris, Sebastian; Schwendicke, Falk

doi:10.1016/j.jdent.2016.03.002

Cited by 217 publications

(193 citation statements)

References 30 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…Evidence supporting the application of probiotics for preventing dental caries is controversial, with recent reports suggesting potential harmful effects for some probiotic bacterial strains [Gruner et al, 2016]. One of the problems identified in using probiotics for caries prevention is that the commonly available Lactobacillus and Bifidobacterium probiotic bacteria are themselves acidogenic and aciduric, and could contribute to the caries process if such bacteria are allowed to colonize the oral cavity [Maltz and Beighton, 2012].…”

Section: Probioticsmentioning

confidence: 99%

Ecological Approaches to Dental Caries Prevention: Paradigm Shift or Shibboleth?

Philip

Suneja²,

Walsh³

2018

Caries Res

135

113

View full text Add to dashboard Cite

Contemporary paradigms of dental caries aetiology focus on the ecology of the dental plaque biofilm and how local environmental factors can modulate this to cause disease. The crucial role that a healthy oral microbiome plays in preventing caries and promoting oral health is also being increasingly recognized. Based on these concepts, several ecological preventive approaches have been developed that could potentially broaden the arsenal of currently available caries-preventive measures. Many of these ecological approaches aim for long-term caries control by either disrupting cariogenic virulence factors without affecting bacterial viability, or include measures that can enhance the growth of health-associated, microbially diverse communities in the oral microbiome. This paper argues for the need to develop ecological preventive measures that go beyond conventional caries-preventive methods, and discusses whether these ecological approaches can be effective in reducing the severity of caries by promoting stable, health-associated oral biofilm communities.

show abstract

Section: Probioticsmentioning

confidence: 99%

Ecological Approaches to Dental Caries Prevention: Paradigm Shift or Shibboleth?

Philip

Suneja²,

Walsh³

2018

Caries Res

135

113

View full text Add to dashboard Cite

show abstract

“…Several clinical trials were conducted in order to study the effect of administration of probiotics in initial treatment of periodontitis [114][115][116][117]. The bacteria most frequently used as probiotic are L. reuteri (DSM 17938 + ATCC PTA 5289) [72,[118][119][120], Lactibacillus salivarius WB21 [121,122], L. reuteri (ATCC 55730 + ATCC PTA 5289) [123], L. reuteri (ATCC PTA 5289) [61], Streptoccus oralis KJ3 + Streptococcus uberis KJ2 + Streptoccus rattus JH145 [124] and L. rhamnosus SP1 [125].…”

Section: Probiotics and Periodontitismentioning

confidence: 99%

Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

View full text Add to dashboard Cite

Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

show abstract

“…However, a more pronounced beneficial effect of saliva-derived lactobacilli was observed in subjects without a history of caries rather than in individuals with arrested or active caries lesions [Simark-Mattsson et al, 2007]. There is still a paucity of evidence to establish a relationship between probiotic administration and DMFt (decayed/missing/filled teeth) scores [Gruner et al, 2016;Tehrani et al, 2016]. In addition, the safety of probiotic use in the oral cavity has been a controversial topic.…”

mentioning

confidence: 99%

“…Although there are limited reports of positive effects for caries prevention and insufficient safety studies, probiotics significantly increased the chance of reducing S. mutans [Gruner et al, 2016], and mutans streptococci are major pathogens of dental caries [Takahashi and Nyvad, 2011], which makes probiotic use in caries prevention a hot topic. Accordingly, the inhibitory activity of probiotics against common oral pathogens (S. mutans, Candida albicans, S. sanguinis) has also been tested in vitro [Soderling et al, 2011;Jiang et al, 2015;Wu et al, 2015;Jiang et al, 2016], and its fermentation profiles have been the subject of studies [Hedberg et al, 2008;Douillard et al, 2013].…”

mentioning

confidence: 99%

Lactobacillus rhamnosus GG in Experimental Oral Biofilms Exposed to Different Carbohydrate Sources

Jiang¹,

Kainulainen²,

Stamatova³

et al. 2018

Caries Res

View full text Add to dashboard Cite

Probiotic administration may favour caries prevention, as recent research has shown. This in vitro study aimed to investigate the growth of Lactobacillus rhamnosus GG (LGG) in experimental biofilms exposed to various carbohydrates, and also to assess its cariogenic potential. Multispecies experimental oral biofilms with or without LGG were grown with a sole-carbohydrate source (fructose/glucose/lactose/sorbitol/sucrose). The viable cells of LGG and structure of the biofilms were examined after 64.5 h of incubation, and pH values of spent media were measured at 16.5, 40.5, and 64.5 h. Fermentation profiles of LGG in biofilm media were assessed with study carbohydrate as the sole energy source. Our results showed that LGG reached higher viable cell numbers with glucose and sucrose in 64.5-h multispecies experimental oral biofilms compared to other carbohydrates. When LGG was incorporated in biofilms, no distinct pH changes at any time points were observed under any of the carbohydrates used; the pH values of spent media at each time point were lower when lactose was used, compared to other carbohydrates. The fermentation profiles of LGG in biofilm media were similar to its growth in MRS (no obvious growth with lactose or sucrose). In conclusion, LGG in our in vitro multispecies experimental oral biofilms was capable of surviving and growing well in each carbohydrate source. LGG might not have harmful effects on dental hard tissues. Another finding from our study was that the lowest pH values were observed in the presence of lactose, and the thickest biofilms were in sucrose.

show abstract

Probiotics for managing caries and periodontitis: Systematic review and meta-analysis

Cited by 217 publications

References 30 publications

Ecological Approaches to Dental Caries Prevention: Paradigm Shift or Shibboleth?

Ecological Approaches to Dental Caries Prevention: Paradigm Shift or Shibboleth?

Probiotics and Periodontal Diseases

Lactobacillus rhamnosus GG in Experimental Oral Biofilms Exposed to Different Carbohydrate Sources

Contact Info

Product

Resources

About