Probiotics: Evidence of Oral Health Implications

Meurman, Jukka H.; Stamatova, Iva

doi:10.1515/folmed-2017-0080

Cited by 47 publications

(37 citation statements)

References 58 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Known mechanisms of probiotics include regulating innate and acquired immunity and releasing antioxidants and bacteriocins to restore the balance of the microbial community and the immune system [20–22]. Meanwhile, it is also reported that probiotics are potentially promising treatment for oral diseases such as periodontal disease, dental caries, halitosis and oral candidiasis [23].…”

Section: Introductionmentioning

confidence: 99%

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Zhou

Young

et al. 2019

BMC Oral Health

View full text Add to dashboard Cite

Background To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis. Methods A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned. Results Six randomized controlled clinical trials and 5 controlled experiments of mouse animal models were included in the systematic review. Four randomized controlled clinical trials comparing a probiotics group with a placebo/blank control group in 480 elderly and denture wearers were included in the meta-analysis. The overall combined odds ratio of the (random effects) meta-analysis was 0.24 (95% CI =0.09–0.63, P < 0.01). The overall combined odds ratio of the (fixed effects) sensitivity analysis was 0.39 (95% CI =0.25–0.60, P < 0.01) by excluding a study with the smallest sample size. These analyses showed that there was a statistically significant difference in the effect of probiotics compared with the control groups in elderly and denture wearers. The remaining 2 studies compared probiotics with other agents in a population aged 18–75 years and children aged 6–14 years respectively, and were analyzed descriptively. Meta-analysis and descriptive analyses indicated that probiotics were potentially effective in reducing morbidity, improving clinical symptoms and reducing oral Candida counts in oral candidiasis. The biases of the included studies were low or uncertain. The relatively common complaints reported were gastrointestinal discomfort and unpleasant taste, and no severe adverse events were reported. Conclusions Probiotics were superior to the placebo and blank control in preventing and treating oral candidiasis in the elderly and denture wearers. Although probiotics showed a favorable effect in treating oral candidiasis, more evidence is required to warrant their effectiveness when compared with conventional antifungal treatments. Moreover, data on the safety of probiotics are still insufficient, and further research is needed.

show abstract

Section: Introductionmentioning

confidence: 99%

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Zhou

Young

et al. 2019

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…Na última década, houve um aumento das pesquisas sobre os probióticos devido ao seu potencial efeito benéfico na saúde periodontal, por meio da formação de compostos antibacterianos, atuando como "competidores" das bactérias periodontopatogênicas pelas ligações das células epiteliais excluindo os microrganismos patogênicos, além de alterar a resposta do hospedeiro, reduzindo citocinas pró-inflamatórias (Alakomi et al, 2000;Szkaradkiewicz et al, 2014;Meurman et al, 2018). animalis subsp.…”

Section: Discussionunclassified

“…Pesquisas confirmaram o resultado positivo dos efeitos das bactérias probióticas nas infecções por vírus da diarreia, distúrbios gastrointestinais, ginecológicos, colite, infecção entérica, câncer de cólon, mucosite induzida por quimioterapia, sintomas de alergia e patologias imunológicas (Harini et al, 2010;Mahasneh et al, 2018: Messora et al, 2013Sahah et al, 2013). Resultados de estudos recentes mostraram que a terapia por meio dos probióticos pode influenciar nas funções do corpo além do intestino, como sistema respiratório e a saúde mental (Harini et al,2010;Meurman et al, 2018). Não há contraindicações absolutas aos probióticos, normalmente há pouco ou nenhum efeito adverso, sendo relatados flatulência leve a moderada e desconforto gástrico, geralmente autolimitados (Kligler & Cohrssen, 2008).…”

Section: Definição E Efeitos Dos Probióticos Na Saúdeunclassified

Probióticos na prevenção e tratamento das doenças periodontais

Massambani

Fernandes

Costa

et al. 2021

RSD

View full text Add to dashboard Cite

A literatura tem demonstrado que os probióticos podem ser um possível aliado na prevenção e tratamento das doenças periodontais. O presente estudo tem como objetivo revisar a literatura quanto ao uso dos probióticos na prevenção e tratamento das doenças periodontais. Na maioria dos estudos clínicos incluídos nessa revisão de literatura, os probióticos apresentaram resultados favoráveis quando usados na prevenção e como auxiliares ao tratamento da gengivite e periodontite, trazendo melhora no índice de placa, índice gengival e redução na profundidade de sondagem, além da redução de microrganismos periodontopatogênicos e alteração da resposta imunológica. Os probióticos apresentaram resultados favoráveis na maioria dos estudos clínicos incluídos nessa revisão de literatura, quando usados na prevenção e como coadjuvante. Entretanto ainda se fazem necessários mais estudos para se estabelecer protocolos mais claros quanto às cepas mais indicadas, meios de utilização e o tempo de uso.

show abstract

“…and interactions between members of these genera have long been of interest to the medical community. For example, many Lactobacillus strains and their cell-free supernatants have antimicrobial activity against Streptococcal pathogens including S. mutans (Rossoni et al 2018;Söderling, Marttinen, and Haukioja 2011;Wasfi et al 2018;Ahn et al 2018) and S. pyogenes (Saroj et al 2016) (Meurman and Stamatova 2018). With a few notable exceptions (Ahn et al 2018), the mechanisms of inhibition is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

UnderstandingLactobacillus paracaseiandStreptococcus oralisbiofilm interactions through agent-based modeling

Archambault

Koshy-Chenthittayil

Thompson

et al. 2021

Preprint

View full text Add to dashboard Cite

As common commensals residing on mucosal tissues, Lactobacillus species are known to encourage health, while recent findings highlight the pathogenic roles of Streptococcus species in these environments. In this study we used a combination of in vivo imaging experiments and computational modeling to explore biofilm interactions between Streptococcus oralis, an accessory pathogen in oral Candidiasis, and Lactobacillus paracasei, an organism with known probiotic properties. A computational agent-based model was created where the two species only interact by competing for space and nutrients. Quantification of bacterial growth in live biofilms indicated that S. oralis biomass and cell numbers were much lower than predicted by the model. Two subsequent models were then created to examine more complex interactions between these species, one where L. paracasei secretes a surfactant, and another where L. paracasei secretes an inhibitor of S. oralis growth. Further biofilm experiments support the hypothesis that L. paracasei may secrete an inhibitor of S. oralis growth, although they do not exclude that a surfactant could also be involved. This contribution shows how agent-based modeling and experiments can be used in synergy to address multiple species biofilm interactions, with important roles in mucosal health and disease.

show abstract

Probiotics: Evidence of Oral Health Implications

Cited by 47 publications

References 58 publications

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Probióticos na prevenção e tratamento das doenças periodontais

UnderstandingLactobacillus paracaseiandStreptococcus oralisbiofilm interactions through agent-based modeling

Contact Info

Product

Resources

About