Probiotics as therapeutic, antioxidant and immunomodulatory agents against poultry coccidiosis

Mohsin, Muhammad; Abbas, Rao Zahid; Yin, Guangwen; Sindhu, Zia-ud-Din; Abbas, Amjad; Huang, Zhijian; Aleem, Muhammad Tahir; Saeed, Zohaib; Afzal, Muhammad Bilal; Ejaz, Adil; Shoaib, Muhammad

doi:10.1080/00439339.2021.1883412

Cited by 13 publications

(13 citation statements)

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“…Vaccination against infectious diseases, plant derivative products, and probiotics are effective approaches against these pathogens (Lin et al 2020;Mohsin et al 2021a). The omics studies (Transcriptomic, genomics, proteomics) are considered the best and authentic alternative approaches for controlling the parasitic diseases in the modern age (Mohsin et al 2021a;2021b).…”

Section: Discussionmentioning

confidence: 99%

“…Scabies is a health-related disorder from the centuries, initiated by digging the mites, but its significance is often underestimated. Despite their problems and risks, parasitic infections, including sexually transmitted diseases, are vastly understudied and have received considerably less public attention (Chen et al 2020;Lin et al 2020;Mohsin et al 2021a;2021b). This chapter aims to elaborate the importance of sexually transmitted parasitic infections and possible protocols for controlling these diseases.…”

Section: Introductionmentioning

confidence: 99%

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Sexually Transmitted Parasitic Infections Both in Humans and Animals

2021

Int J Vet Sci

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sexually Transmitted Parasitic Infections Both in Humans and Animals

2021

Int J Vet Sci

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“…Due to these problems, alternative strategies for controlling coccidiosis are needed for this age [13]. Probiotics are considered safe and appealing alternatives in controlling enteric pathogens, including Eimeria parasites [14,15]. They can also compensate for the various issues related to the use of anticoccidial vaccines and drugs [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…Probiotics are non-pathogenic microbes that can maintain normal intestinal microbiota and positive activity against intestinal diseases [16]. Probiotics supplementation in the poultry feed enhances the activity of beneficial microbes in the gastrointestinal tract (GIT) [14], increases the performance of digestive enzymes, stimulates the humoral and cell-mediated immunity [4,14], and also neutralizes various enterotoxins [17,18]. Probiotics positively affect the blood parameters, carcass traits, intestinal microflora, growth, and immune functions of the birds [19].…”

Section: Introductionmentioning

confidence: 99%

“…Probiotics positively affect the blood parameters, carcass traits, intestinal microflora, growth, and immune functions of the birds [19]. Probiotics can act as anticoccidial agents, with immunomodulators such as improved Toll-like receptor expression [20], cytokine stimulation [21], antibody development [15,22], antioxidant effect [23,24], lower lesion score [4], decreased oocysts shedding [3,25], less fecal score [14], as well as neutralizing various enterotoxins. Based on these results, probiotics have been considered as potential anticoccidial agents; however, there is limited confirmation [26].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Probiotics on the Performance and Intestinal Health of Broiler Chickens Infected with Eimeria tenella

2022

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Coccidiosis is an important parasitic disease of poultry with great economic importance. Due to drug resistance issues, the study was conducted to investigate how probiotics (Lactobacillus plantarum or L. plantarum) affected oocysts per gram of feces (OPG), fecal scores, feed conversion ratio (FCR), immunomodulatory effect in terms of the cell-mediated and humoral immune response. Serum chemistry (ALT, AST, LDH, and creatinine) was measured in different treated chicken groups. mRNA expression levels of antioxidant enzymes (SOD 1 and CAT), peptide transporter 1 (PepT 1), and tight junction proteins (ZO and CLDN 1) were also examined in chicken groups infected with Eimeria tenella (E. tenella). Chickens supplemented with L. plantarum 1 × 108 CFU (colony-forming unit) showed an improved cell-mediated and humoral immune response, compared with the control group (p < 0.05). Probiotics also enhanced the performance of antioxidant enzymes, PepT 1, and tight junction proteins, and improved serum chemistry (AST, ALT, and LDH), compared with control-infected, non-medicated chickens. However, no significant difference (p > 0.05) was observed in CLDN 1 expression level and creatinine in all treated chicken groups. These findings demonstrated that probiotics supplementation in the feed can protect the birds against E. tenella infection.

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Isolation of saprophytic filamentous fungi from avian fecal samples and assessment of its predatory activity on coccidian oocysts

Lozano

Louro

Almeida³

et al. 2023

Sci Rep

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Fungal strains used in the biocontrol of animal gastrointestinal parasites have been mainly isolated from pasture soil, decaying organic matter, and feces from herbivores and carnivores. However, their isolation from birds and assessment of predatory activity against avian GI parasites has been scarce thus far. This research aimed to isolate filamentous fungi from avian fecal samples and evaluate their predatory activity against coccidia. A pool of 58 fecal samples from chickens, laying hens, and peacocks, previously collected between July 2020-April 2021, were used for isolation of filamentous fungi and assessment of their in vitro predatory activity against coccidian oocysts, using Water-Agar medium and coprocultures. The Willis-flotation technique was also performed to obtain concentrated suspensions of oocysts. A total of seven Mucor isolates was obtained, being the only fungal taxa identified, and all presented lytic activity against coccidia. Isolates FR3, QP2 and SJ1 had significant coccidiostatic efficacies (inhibition of sporulation) higher than 70%, while isolates FR1, QP2 and QP1 had coccidicidal efficacies (destruction of the oocysts) of 22%, 14% and 8%, respectively, after 14 days of incubation, being a gradual and time-dependent process. To our knowledge, this is the first report regarding the isolation of native predatory fungi from avian feces and demonstration of their lytic activity against coccidia.

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Probiotics as therapeutic, antioxidant and immunomodulatory agents against poultry coccidiosis

Cited by 13 publications

References 74 publications

Sexually Transmitted Parasitic Infections Both in Humans and Animals

Sexually Transmitted Parasitic Infections Both in Humans and Animals

Effect of Probiotics on the Performance and Intestinal Health of Broiler Chickens Infected with Eimeria tenella

Isolation of saprophytic filamentous fungi from avian fecal samples and assessment of its predatory activity on coccidian oocysts

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