Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Zanetta, Paola; Ormelli, Margherita; Amoruso, Angela; Pane, Marco; Azzimonti, Barbara; Squarzanti, Diletta Francesca

doi:10.3390/ijms23073489

Cited by 8 publications

(3 citation statements)

References 201 publications

(245 reference statements)

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“…MMP activity may be also associated with other oral diseases and problems like the failure of adhesive restorations over time [ 105 ]; oral lichen planus [ 63 ] and its transformation from reticular to erosive forms and further to carcinoma [ 121 ]; desquamative gingivitis associated with oral lichen planus [ 122 ]; odontogenic cysts and tumors (such as dentigerous cyst, odontogenic keratocyst, and unicystic ameloblastoma) [ 123 ]; as well as periodontitis.…”

Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

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The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular network present within all tissues and organs, forming the foundation on which cells sit, and composed of proteins (such as collagen), glycosaminoglycans, proteoglycans, minerals, and water. The ECM provides a fundamental framework for the cellular constituents of tissue and biochemical support to surrounding cells. The ECM is a highly dynamic structure that is constantly being remodeled. Matrix metalloproteinases (MMPs) are among the most important proteolytic enzymes of the ECM and are capable of degrading all ECM molecules. MMPs play a relevant role in physiological as well as pathological processes; MMPs participate in embryogenesis, morphogenesis, wound healing, and tissue remodeling, and therefore, their impaired activity may result in several problems. MMP activity is also associated with chronic inflammation, tissue breakdown, fibrosis, and cancer invasion and metastasis. The periodontium is a unique anatomical site, composed of a variety of connective tissues, created by the ECM. During periodontitis, a chronic inflammation affecting the periodontium, increased presence and activity of MMPs is observed, resulting in irreversible losses of periodontal tissues. MMP expression and activity may be controlled in various ways, one of which is the inhibition of their activity by an endogenous group of tissue inhibitors of metalloproteinases (TIMPs), as well as reversion-inducing cysteine-rich protein with Kazal motifs (RECK).

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Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

View full text Add to dashboard Cite

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“…Probiotic-based adjuvant therapies may be useful for treating or even prevent these chronic infections and restoring the oral microbiota, achieving benefits for oral health and the overall wellbeing [21,[23][24][25]. The major goal of probiotic treatment is to enhance the presence of beneficial commensal bacteria, which might be able to trigger an anti-inflammatory response as well as an antibacterial and anti-adhesive effect against pathogenic microbes [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Squarzanti,

Dell'Atti,

Scalia

et al. 2024

Preprint

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The microbiota in the oral cavity has a strict connection to its host. Its unbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains (Lactobacillus acidophilus PBS066, Lactobacillus crispatus LCR030, Lactobacillus gasseri LG050, Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, Lacticaseibacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050, Lacticaseibacillus paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114) against two main oral pathogens, Streptococcus mutans and Aggregatibacter actinomycetemcomitans, involved in dental caries and periodontal disease development and progression. Our results, obtained through agar overlay assay, plate count method, and scanning electron microscope imaging, indicate that the tested probiotics prevent the growth and adhesion of oral pathogens in a strain-specific manner, improving oral health. L. plantarum PBS067, L. rhamnosus LRH020, L. paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114 performed in a significant way against both pathogens in all the tests used. They can be considered as an effective adjuvant to guarantee oral and systemic well-being.

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“…Probiotic-based adjuvant therapies may be useful for treating or even preventing these chronic infections and restoring the oral microbiota, achieving benefits for oral health and the overall well-being [ 26 , 29 , 30 , 31 , 32 ]. The major goal of probiotic treatment is to enhance the presence of beneficial commensal bacteria, which might be able to trigger an anti-inflammatory response as well as an antibacterial and antiadhesive effect against pathogenic microbes [ 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens

Squarzanti,

Dell’Atti,

Scalia

et al. 2024

Microorganisms

Self Cite

View full text Add to dashboard Cite

The microbiota in the oral cavity has a strict connection to its host. Its imbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains (Lactobacillus acidophilus PBS066, Lactobacillus crispatus LCR030, Lactobacillus gasseri LG050, Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, Lacticaseibacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050, Lacticaseibacillus paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114) against two main oral pathogens, Streptococcus mutans and Aggregatibacter actinomycetemcomitans, involved in dental caries and periodontal disease development and progression. Considering both the agar overlay preventive and treatment models, seven probiotics determined greater inhibition zones against the tested pathogens. This behavior was further analyzed by the plate count method and scanning electron microscope imaging. L. plantarum PBS067, L. rhamnosus LRH020, L. paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114 prevent the growth and adhesion of oral pathogens in a strain-specific manner (p < 0.0001). These probiotics might be considered as an alternative effective adjuvant to improve oral and systemic well-being for future personalized treatments.

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Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What’s New?

Cited by 8 publications

References 201 publications

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains Against Oral Pathogens

Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens

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