Probiotics are helpful in hepatic encephalopathy: a meta‐analysis of randomized trials

Saab, Sammy; Suraweera, Duminda; Au, Jennifer; Saab, Elena G.; Alper, Tori S.; Tong, Myron J.

doi:10.1111/liv.13005

Cited by 70 publications

(50 citation statements)

References 45 publications

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“…covert) HE 60. However, these effects were not observed when probiotic use was compared to lactulose.…”

Section: Other Treatment Regimensmentioning

confidence: 93%

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

Elwir¹,

Rahimi²

2017

Journal of Clinical and Translational Hepatology

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Hepatic encephalopathy is a spectrum of reversible neuropsychiatric abnormalities, seen in patients with liver dysfunction and/or portosystemic shunting. One of the most debilitating complications of cirrhosis, encephalopathy affects 30–45% of cirrhotics. In addition to significantly affecting the lives of patients and their caregivers, it is also associated with increased morbidity and mortality as well as significant utilization of health care resources. In this paper, we provide an overview on the pathophysiology, diagnosis, management and newer therapies of hepatic encephalopathy.

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“…covert) HE 60. However, these effects were not observed when probiotic use was compared to lactulose.…”

Section: Other Treatment Regimensmentioning

confidence: 93%

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

Elwir¹,

Rahimi²

2017

Journal of Clinical and Translational Hepatology

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“…Hepatic Encephalopathy: Probiotics seem to be effective for the treatment of hepatic encephalopathy. A meta-analysis of six RCTs involving 496 adults with cirrhosis showed that probiotic therapy significantly reduced the development of overt hepatic encephalopathy (Saab et al, 2015).…”

Section: Evidence For the Therapeutic Use Of Probioticsmentioning

confidence: 99%

Role of Probiotics in Health and Disease –A Review

Sen

2019

IJALSR

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Human intestinal microbiota has undergone a lot of research in recent years and we are beginning to expand our knowledge of the role of bacteria, fungi, viruses and helminths in our gut in health and disease. Our gut contains myriad of over hundreds of millions of microbes that influence our body physiology, nutrition, metabolism, and immunity. A change in the type of these microbes has been shown to be associated with gastrointestinal diseases such as inflammatory bowel disease and systemic diseases like metabolic syndrome and cancer. In this article, an attempt has been made to review some significant recent studies that have looked into the complex types of intestinal microbes and how they interact with the human body. This paper also serves to explain what probiotics are, and how they function as a separate "organ" within our body. It includes their method of action, the latest evidence-based research on their use in health and disease and some common sources of probiotic bacteria.

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“…More recently, nascent data have been emerging on the use of probiotics to treat HE and have shown improved quality of life in these patients, but mortality benefits are still unclear with use of probiotics, and available quality of evidence is still low. 76,77 PPIs have been shown to be associated with development of HE. 78,79 Patients prescription list should be checked for PPI, and PPIs should be discontinued unless there is a clear indication for their use.…”

Section: Hepatic Encephalopathymentioning

confidence: 99%

Medical Management of Portal Hypertension and Its Complications

Singh

McCullough

2017

Dig Dis Interv

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Portal hypertension, most commonly caused by cirrhosis, is defined as an elevated hepatic venous pressure gradient that can lead to complications including ascites, hepatic, esophageal/gastric varices, hepatic encephalopathy, and hepatorenal syndrome. While these complications are initially managed by medical and endoscopic treatments, progressive decompensation of liver disease may lead to liver transplantation.

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Probiotics are helpful in hepatic encephalopathy: a meta‐analysis of randomized trials

Abstract: Overall the use of probiotics was more effective in decreasing hospitalization rates, improving MHE and preventing progression to OHE in patients with underlying MHE than placebo, but similar to that seen with lactulose. The use of probiotics did not affect mortality rates.

Cited by 70 publications

References 45 publications

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

Role of Probiotics in Health and Disease –A Review

Medical Management of Portal Hypertension and Its Complications

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