Probiotics and Trained Immunity

Cortes-Perez, Naima G.; LeBlanc, Alejandra de Moreno de; Gómez-Gutiérrez, Jorge G.; LeBlanc, Jean Guy; Bermúdez‐Humarán, Luis G.

doi:10.3390/biom11101402

Cited by 24 publications

(13 citation statements)

References 180 publications

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“… 52 Further, microbial metabolites, including those produced by probiotics, have the potential to travel to the bone marrow where they epigenetically imprint hematopoietic progenitors. 53 , 54 Therefore, selective modulation of the intestinal microbiota could have long-term benefits to the host and it is of great importance to determine which probiotics or probiotic compounds that are capable of imprinting memory responses in innate cells. This could be beneficial for future therapeutic interventions where, for instance, excessive inflammation is necessary to be regulated.…”

Section: Discussionmentioning

confidence: 99%

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

et al. 2022

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Memory-like responses in innate immune cells confer nonspecific protection against secondary exposures. A number of microbial agents have been found to induce enhanced or diminished recall responses in innate cells, however, studies investigating the ability of probiotic bacteria to trigger such effects are lacking. Here, we show that priming of human monocytes with a secretome from the gut probiotic bacterium Limosilactobacillus ( L .) reuteri induces a mixed secondary response phenotype in monocyte-derived dendritic cells (mo-DCs), with a strong IL-6 and IL-1β response but low TNFα, IL-23 and IL-27 secretion. Instead, blood DC priming with L. reuteri -secretome resembles a tolerant state upon secondary exposure. A similar pattern was found in conventional and gut-like (retinoic acid exposed) DCs, although retinoic acid hampered TNFα and IL-6 production and enrichment of histone modifications in L. reuteri -secretome primed mo-DC cultures. Further, we show that the memory-like phenotype of mo-DCs, induced by priming stimuli, is important for subsequent T helper (Th) cell differentiation pathways and might determine the inflammatory nature of Th cells. We also show enhanced recall responses characterized by robust inflammatory cytokines and lactate production in the gut-like mo-DCs derived from β-glucan primed monocytes. Such responses were accompanied with enriched histone modifications at the promoter of genes associated with a trained phenotype in myeloid cells. Altogether, we demonstrate that a gut commensal-derived secretome prompts recall responses in human DCs which differ from that induced by classical training agents such as β-glucan. Our results could be beneficial for future therapeutic interventions where T cell responses are needed to be modulated.

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Section: Discussionmentioning

confidence: 99%

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

et al. 2022

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“…We demonstrated that anti-TLR2 antibody blocked LAB-induced IFN-γ and TNF-α secretion but had no inhibitory effect on IL-12. Thus, the immune responses of HY8002 and HY7717 may be associated with PRRs such as other TLRs or NOD-like receptors (NLRs) [ 52 ]. TLR2 is a major receptor of both HY8002 and HY7717 and promotes immune activity in splenocytes.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717

Kim¹,

Kim²,

Kim³

et al. 2022

J Anim Sci Technol

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“…Also, by fermenting dietary fibers, probiotics can produce SCFAs (short-chain fatty acids), such as butyrate, propionate, and acetate, with protective properties against intestinal pathogens [ 44 ]. Moreover, probiotics have been associated to decreased secretion of inflammatory cytokines such as tumor necrosis factor-α, interferon-γ, and interleukin-1, and increased production of the anti-inflammatory cytokines such as interferon-α and interleukin-10 [ 45 , 46 , 47 ]. Some species displayed the capacity to stimulate immunoglobulin A secretion in Peyer patches [ 48 ].…”

Section: Probiotics and Their Mechanisms Of Actionsmentioning

confidence: 99%

Lactobacillus paracasei CNCM I 1572: A Promising Candidate for Management of Colonic Diverticular Disease

Bretto

D’Amico

Fiore

et al. 2022

JCM

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Diverticular disease (DD) is a common gastrointestinal condition. Patients with DD experience a huge variety of chronic nonspecific symptoms, including abdominal pain, bloating, and altered bowel habits. They are also at risk of complications such as acute diverticulitis, abscess formation, hemorrhage, and perforation. Intestinal dysbiosis and chronic inflammation have recently been recognized as potential key factors contributing to disease progression. Probiotics, due to their ability to modify colonic microbiota balance and to their immunomodulatory effects, could present a promising treatment option for patients with DD. Lactobacillus paracasei CNCM I 1572 (LCDG) is a probiotic strain with the capacity to rebalance gut microbiota and to decrease intestinal inflammation. This review summarizes the available clinical data on the use of LCDG in subjects with colonic DD.

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Probiotics and Trained Immunity

Cited by 24 publications

References 180 publications

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717

Lactobacillus paracasei CNCM I 1572: A Promising Candidate for Management of Colonic Diverticular Disease

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