Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial

Kukkonen, Kaarina; Savilahti, Erkki; Haahtela, Tari; Juntunen‐Backman, Kaisu; Korpela, Riitta; Poussa, Tuija; Tuure, Tuula; Kuitunen, Mikael

doi:10.1016/j.jaci.2006.09.009

Cited by 610 publications

(518 citation statements)

References 34 publications

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“…[119][120][121]124 In three of the trials, the rates of sensitization also did not differ signifi cantly between the probiotic and the placebo group. 121,124,125 Supplementation with L. reuteri ATCC 55730 lowered the incidence of skin prick reactivity in infants with mothers with allergies. 120 In contrast, ingestion of L. acidophilus LAVRI for the fi rst 6 months of life raised the rate of sensitization to a variety of food and inhalant allergens tested.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 90%

“…This protective effect was maintained at the ages of 4 and 7 years. 122,123 However, others were unable to confi rm a preventative effect of LGG supplementation, 124,125 and the results of primary prevention trials using other probiotics are variable and not as impressive as those obtained by Kalliomäki et al 121 (as summarized in Table 5). …”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

“…shermanii in combination with a prebiotic. 124,129 This was based on an analysis of plasma levels of cytokines and infl ammatory markers in a randomly selected subgroup of participants in a large primary prevention trial, which indicated that increased plasma C-reactive pro tein (CRP) concentrations in infants at 6 months of age were associated with decreased risk of eczema and allergic disease at 2 years of age after adjustment for probiotic use. 129 This was also observed in a separate analysis of the placebo group.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

“…131 Interestingly, the same four probiotics given in combination with a prebiotic reduced the incidence of eczema and atopic eczema and tended to reduce IgEassociated diseases overall in a primary prevention trial. 124 This may suggest that probiotics have different effects in developing compared with in established disease. Alternatively, the addition of prebiotic galactooligosaccharides may have been the decisive difference, although clear evidence of its bifi dogenic effect is still lacking.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

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Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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Section: Probiotics In Allergic Diseasesmentioning

confidence: 90%

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

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Probiotics and immunity

et al. 2009

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“…A genetic analysis of the composition of the intestinal microbial flora was performed on a subgroup of 45 patients, showing a high prevalence of probiotic flora in the gut and, in particular, the presence of numerous L. casei DN-114001 colonies in patients receiving the intervention as compared to the control group: gut colonization by probiotics persisted after 6 and 12 months in almost all subjects. Numerous studies have shown promising results on the effectiveness of probiotics in reducing the incidence of allergic reactions [77][78][79][80].…”

Section: Allergic and Atopic Diseases In Childrenmentioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

229

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Prebiotic Supplementation in Full-term Neonates

Rao¹,

Srinivasjois²,

Patole³

2009

Arch Pediatr Adolesc Med

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Objective: To systematically review randomized controlled trials evaluating the efficacy and safety of prebiotic supplementation in full-term neonates. Data Sources: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and CINAHL databases and proceedings of relevant conferences. Study Selection: Eleven of 24 identified trials (n=1459) were eligible for inclusion. Intervention: Trials comparing formula milk supplemented with or without prebiotics, commenced at or before age 28 days and continued for 2 weeks or longer. Main Outcome Measures: Stool colony counts (bifidobacteria, lactobacilli, and pathogens), pH, consistency, frequency, anthropometry, and symptoms of intolerance. Results: Six trials reported significant increases and 2 reported a trend toward increases in bifidobacteria counts after supplementation. Meta-analysis estimated signifi

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Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial

Cited by 610 publications

References 34 publications

Probiotics and immunity

Probiotics and immunity

Probiotics and health: An evidence-based review

Prebiotic Supplementation in Full-term Neonates

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