Probiotics and metabolites regulate the oral and gut microbiome composition as host modulation agents in periodontitis: A narrative review

Deandra, Fathia Agzarine; Ketherin, Ketherin; Rachmasari, Rieska; Sulijaya, Benso; Takahashi, Naoki

doi:10.1016/j.heliyon.2023.e13475

Cited by 19 publications

(11 citation statements)

References 70 publications

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“…[ 36 ] Since TLR4 and its downstream NF‐ κ B are redox‐sensitive molecules, activation of this signal is known to be involved in OS and inflammation throughout, leading to periodontal tissue damage. [ 37 ] Following recognition of LPS by TLR4, it triggers an intercellular signaling cascade that activates the downstream NF‐ κ B pathway. The expression levels of TLR4 and NF‐ κ B were significantly downregulated after the NAC‐CPDs treatment, indicating that NAC‐CPDs inhibited the TLR4‐regulated NF‐ κ B pathway.…”

Section: Resultsmentioning

confidence: 99%

N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis

Liu

Hou

Xin

et al. 2023

Adv Healthcare Materials

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Periodontitis is a type of chronic inflammatory oral disease characterized by the destruction of periodontal connective tissue and progressive alveolar bone resorption. As oxidative stress is the key cause of periodontitis in the early periodontal microenvironment, antioxidative therapy has been considered a viable treatment for periodontitis. However, more stable and effective reactive oxygen species (ROS)‐scavenging nanomedicines are still highly needed due to the instability of traditional antioxidants. Herein, a new type of N‐acetyl‐l‐cysteine (NAC)‐derived red fluorescent carbonized polymer dots (CPDs) has been synthesized with excellent biocompatibility, which can serve as an extracellular antioxidant to scavenge ROS effectively. Moreover, NAC‐CPDs can promote osteogenic differentiation in human periodontal ligament cells (hPDLCs) under H2O2 stimulation. In addition, NAC‐CPDs are capable of targeted accumulation in alveolar bone in vivo, reducing the level of alveolar bone resorption in periodontitis mice, as well as performing fluorescence imaging in vitro and in vivo. In terms of mechanism, NAC‐CPDs may regulate redox homeostasis and promote bone formation in the periodontitis microenvironment by modulating the kelch‐like ECH‐associated protein l (Keap1)/nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway. This study provides a new strategy for the application of CPDs theranostic nanoplatform for periodontitis.

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Section: Resultsmentioning

confidence: 99%

N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis

Liu

Hou

Xin

et al. 2023

Adv Healthcare Materials

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“…They act as an anti-inflammatory and antibacterial agent and can adhere to oral tissue by colonizing the epithelial cells and altering the pathogen bacteria. These therapies may help restore microbial balance, reduce inflammation, and support periodontal tissue healing [83,84].…”

Section: Novel Therapiesmentioning

confidence: 99%

Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review

Radu,

Arbănaşi

et al. 2024

Life

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Periodontitis, a prevalent oral condition, is facing difficulties in therapeutic approaches, sometimes leading to failure. This literature review was conducted to investigate the diversity of other therapeutic approaches and their potential contributions to the successful management of the disease. This research scrutinized the alterations in microbial diversity and imbalances in crucial microbial species, which contribute significantly to the pathogenesis of periodontitis. Within the limitations of this study, we highlight the importance of understanding the treatment plan’s role in periodontitis disease, opening the way for further research and innovative treatment plans to mitigate the impact of periodontitis on oral health. This will aid both healthcare professionals and patients in preventing and effectively treating periodontitis, ultimately improving oral health outcomes and overall systemic health and well-being.

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“…Altered mucosal microbiota and microbial translocation are hallmarks of HIV infection [27,39]. PLWH are highly susceptible to oral infections and altered oral microbial dysbiosis, leading to gingivitis and periodontitis, which in turn can cause loss of periodontal ligament, alveolar bone structure, and loss of teeth [40][41][42][43]. Indeed, NKB cells have been implicated in…”

Section: Plos Pathogensmentioning

confidence: 99%

Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques

Manickam,

Upadhyay,

Woolley

et al. 2024

PLoS Pathog

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Natural killer-like B (NKB) cells are unique innate immune cells expressing both natural killer (NK) and B cell receptors. As first responders to infection, they secrete IL-18 to induce a critical cascade of innate and adaptive immune cell infiltration and activation. However, limited research exists on the role of NKB cells in homeostasis and infection, largely due to incomplete and erroneous evaluations. To fill this knowledge gap, we investigated the expression of signaling and trafficking proteins, and the in situ localization and transcriptome of naïve NKB cells comparied to conventionally-defined NK and B cells, as well as modulations of these cells in SIV infection. Intracellular signaling proteins and trafficking markers were expressed differentially on naïve NKB cells, with high expression of CD62L and Syk, and low expression of CD69, α4β7, FcRg, Zap70, and CD3z, findings which were more similar to B cells than NK cells. CD20+NKG2a/c+ NKB cells were identified in spleen, mesenteric lymph nodes (MLN), colon, jejunum, and liver of naïve rhesus macaques (RM) via tissue imaging, with NKB cell counts concentrated in spleen and MLN. For the first time, single cell RNA sequencing (scRNAseq), including BCR sequencing, of sorted NKB cells confirmed that NKB cells are unique. Transcriptomic analysis of naïve splenic NKB cells by scRNAseq showed that NKB cells undergo somatic hypermutation and express Ig receptors, similar to B cells. While only 15% of sorted NKB cells showed transcript expression of both KLRC1 (NKG2A) and MS4A1 (CD20) genes, only 5% of cells expressed KLRC1, MS4A1, and IgH/IgL transcripts. We observed expanded NKB frequencies in RM gut and buccal mucosa as early as 14 and 35 days post-SIV infection, respectively. Further, mucosal and peripheral NKB cells were associated with colorectal cytokine mileu and oral microbiome changes, respectively. Our studies indicate that NKB cells gated on CD3-CD14-CD20+NKG2A/C+ cells were inclusive of transcriptomically conventional B and NK cells in addition to true NKB cells, confounding accurate phenotyping and frequency recordings that could only be resolved using genomic techniques. Although NKB cells were clearly elevated during SIV infection and associated with inflammatory changes during infection, further interrogation is necessary to acurately identify the true phenotype and significance of NKB cells in infection and inflammation.

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Probiotics and metabolites regulate the oral and gut microbiome composition as host modulation agents in periodontitis: A narrative review

Cited by 19 publications

References 70 publications

N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis

N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis

Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review

Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques

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