Probiotics and Inflammatory Pain: A Literature Review Study

Nazemian, Vida; Shadnoush, Mahdi; Manaheji, Homa; Zaringhalam, Jalal

doi:10.17795/mejrh-36087

Cited by 14 publications

(11 citation statements)

References 63 publications

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“…In the case of persistent pain states, mounting evidence has illustrated that the release of a variety of inflammatory mediators, such as cytokines and growth factors from neuronal and non-neuronal cells, play a crucial role in the induction of inflammatory pain [1]. Although tremendous efforts have been made to understand the cellular and molecular basis of chronic pain, its physiological aspects remains mostly unknown [2,3]. Multiple mechanisms contribute to inflammatory pain, each of which is subject to cellular and molecular alterations of nociceptive neurons in the dorsal horn of the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

Taghizadeh

Maghsoudi

Manaheji

et al. 2020

Preprint

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Background: There are largely unknown associations between changes in pain behavior responses during persistent peripheral inflammation and spinal cell alteration such as apoptosis. Some evidence suggests that microglia and microglia related mediators play notable roles in induction and maintenance of central nervous system pathologies and inflammatory pain. By considering those relationships and microglia related nootrophic factors, such as the Brain Derived Neurotrophic Factor (BDNF) in CNS, we attempted to assess the relationship between microglia dependent BDNF and its precursor with pain behavior through spinal cell apoptosis as well as the effect of Noopept on this relationship. Methods: Persistent peripheral inflammation was induced by a single subcutaneous injection of Complete Freund’s Adjuvant (CFA) on day 0. Thermal hyperalgesia, paw edema, microglial activity, microglia dependent BDNF, pro-BDNF expression, and apoptosis were assessed in different experimental groups by confirmed behavioral and molecular methods on days 0, 7, and 21 of the study. Results: Our findings revealed hyperalgesia and spinal cell apoptosis significantly increased during the acute phase of CFA-induced inflammation but was then followed by a decrement in the chronic phase of the study. Aligned with these variations in spinal microglial activity, microglia dependent BDNF significantly increased during the acute phase of CFA-induced inflammation. Our results also indicated that daily administration of Noopept (during 21 days of the study) not only caused a significant decrease in hyperalgesia and microglia dependent BDNF expression but also changed the apoptosis process in relation to microglia activity alteration. Conclusions: It appears that the administration of Noopept can decrease spinal cell apoptosis and hyperalgesia during CFA-induced inflammation due to its direct effects on microglial activity and microglia dependent BDNF and pro-BDNF expression.

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Section: Introductionmentioning

confidence: 99%

Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

Taghizadeh

Maghsoudi

Manaheji

et al. 2020

Preprint

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“…These properties and protective effects of F. prausnitzii were identified in different models such as dinitrobenzene sulfate (DNBS)-induced colitis model, dextran sodium sulfate (DSS)-induced colitis ( Breyner et al, 2017 ), and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis in mice ( Miquel et al, 2015 ). Additionally, levels of anti-inflammatory cytokines and immunoglobulins, immune cell proliferation, and production of proinflammatory cytokines produced by the T cells may be modulated following probiotic supplementation ( Miettinen et al, 1996 ; Nazemian et al, 2016 ). Furthermore, probiotics can be alternative strategies for inflammatory disorders, as they upregulate the production of CD4+Foxp3+ regulatory T cells (T regs ) ( Kwon et al, 2010 ; Yan and Polk, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging Trends in “Smart Probiotics”: Functional Consideration for the Development of Novel Health and Industrial Applications

2017

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The link between gut microbiota and human health is well-recognized and described. This ultimate impact on the host has contributed to explain the mutual dependence between humans and their gut bacteria. Gut microbiota can be manipulated through passive or active strategies. The former includes diet, lifestyle, and environment, while the latter comprise antibiotics, pre- and probiotics. Historically, conventional probiotic strategies included a phylogenetically limited diversity of bacteria and some yeast strains. However, biotherapeutic strategies evolved in the last years with the advent of fecal microbiota transplant (FMT), successfully applied for treating CDI, IBD, and other diseases. Despite the positive outcomes, long-term effects resulting from the uncharacterized nature of FMT are not sufficiently studied. Thus, developing strategies to simulate the FMT, using characterized gut colonizers with identified phylogenetic diversity, may be a promising alternative. As the definition of probiotics states that the microorganism should have beneficial effects on the host, several bacterial species with proven efficacy have been considered next generation probiotics. Non-conventional candidate strains include Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides fragilis, and members of the Clostridia clusters IV, XIVa, and XVIII. However, viable intestinal delivery is one of the current challenges, due to their stringent survival conditions. In this review, we will cover current perspectives on the development and assessment of next generation probiotics and the approaches that industry and stakeholders must consider for a successful outcome.

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“…Inflammatory pain is a type of pathological pain caused by direct stimulation of nociceptors, which are altered by release of many inflammatory mediators such as bradykinin, histamine and cytokines (3,4). Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which is characterized by pain, edema, hyperalgesia, allodynia and cartilage and bone destruction (3).…”

Section: Introductionmentioning

confidence: 99%

“…Probiotic bacteria, including Lactobacillus and Bifidobacterium species, can inhibit the growth of many types of pathological cells and may also have more direct effects on the immune system. Probiotics have immune regulatory properties and can modify the function (proliferation, activation and effective performance) of a wide variety of immune cells including B-lymphocytes, T-lymphocytes, anti and pro-inflammatory cytokines production and modulating the intracellular signaling pathways including NF-κB (4,8).…”

Section: Introductionmentioning

confidence: 99%

Effect of Probiotic Administration on Acute Inflammatory Pain

Shadnoush

Nazemian

Manaheji

et al. 2016

Middle East J Rehabil Health

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Background: Acute inflammatory pain causes by direct stimulation of nociceptors and release of inflammatory mediators and cytokines. Probiotics are capable to modulate the immune system, down regulate the inflammatory mediators, and increase regulatory and anti-inflammatory cytokines. Objectives: The aim of this study was to examine the effect of oral administration of probiotics on behavioral, cellular and molecular aspects of acute inflammatory pain in male rats. Methods: Adult male Wistar rats (200 -220 g) were selected and randomly divided into 7 experimental groups (CFA, CFA control, CFA + vehicle (distilled water), CFA + 3 doses of probiotics, CFA + indomethacin) and each group was divided into 3 subgroups based on different time points (days 0, 3, and 7) (n = 6 rats, each group). Complete Freund's adjuvant (CFA)-induced arthritis (AA) was caused by a single subcutaneous injection of CFA into the rats' left hind paw on day 0. Different doses of probiotics (1/250, 1/500 and 1/1000 (10 9 CFU/g)) was administered daily (gavage) after the CFA injection. Blood samples were taken from the vessel retro-orbital corners

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Probiotics and Inflammatory Pain: A Literature Review Study

Cited by 14 publications

References 63 publications

Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

Emerging Trends in “Smart Probiotics”: Functional Consideration for the Development of Novel Health and Industrial Applications

Effect of Probiotic Administration on Acute Inflammatory Pain

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